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Events Calendar

  • Design of a RECYCLABLE CAR with Durable Antitumor Function

    Wednesday, September 23, 2020

    9:00 AM-10:30 AM

    Remote

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff

    BIOMED Seminar

    Title:
    Design of a RECYCLABLE CAR with Durable Antitumor Function

    Speaker:
    Haopeng Wang, PhD
    Assistant Professor
    School of Life Science and Technology
    ShanghaiTech University

    Details:
    Chimeric antigen receptor-T cell (CAR-T) therapy offers a promising approach for cancer immunotherapy. However, increasing clinical evidence suggests poor CAR-T persistence in patients limits the therapeutic efficacy. Here, we design a new type of CAR recyclable capability to promote in vivo persistence and to sustain antitumor activity. Firstly, we observed that the engagement of tumor antigens induced rapid ubiquitination of CARs, causing CAR down-modulation followed by lysosomal degradation.

    Blocking CAR ubiquitination by mutating all lysines in the CAR cytoplasmic domain (CARKR) markedly repressed CAR downmodulation by inhibiting lysosomal degradation while enhancing recycling of internalized CARs back to the cell surface. Upon encountering tumor antigens, CARKR-T cells ameliorated the loss of surface CARs, which promoted their long-term killing capacity. Moreover, CARKR-T cells containing 4-1BB signaling motifs displayed elevated endosomal 4-1BB signaling that enhanced oxidative phosphorylation and promoted memory T cell differentiation, leading to superior persistence in vivo. Collectively, our study provides a straightforward strategy to optimize CAR-T antitumor efficacy by redirecting CAR trafficking.

    Biosketch:
    Haopeng Wang, PhD, is an assistant professor in the School of Life Science and Technology at ShanghaiTech University. Dr. Haopeng is an experienced immunologist who has studied T cell biology for more than 15 years. He received his PhD while working in the lab of Dr. Dario A. Vignali at St. Jude Children’s Research Hospital, and completed his post-doctoral training in the lab of Dr. Arthur Weiss lab at the University of California, San Francisco (UCSF). In 2015, Dr. Wang started his independent research at ShanghaiTech University. Wang lab aims to use a multidisciplinary approach to achieve a better understanding of T cell signaling pathways, which would be beneficial for the development of therapeutic strategies for immune disorders and cancer immunotherapy.

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  • 2nd Annual Immune Modulation & Engineering Symposium (IMES)

    November 11, 2020 through November 13, 2020

    9:00 AM-4:00 PM

    Virtual

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff
    The 2nd Annual Immune Modulation & Engineering Symposium (IMES) featuring thought leaders from industry and academia will take place November 11-13, 2020. This year’s symposium will be fully virtual and will feature a research competition for trainees. Top abstracts will be selected for live or pre-recorded talks and will receive cash prizes. Deadline for abstract submission is Wednesday, September 30, 2020. To register, please click here.
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20 Years as a School, 60 Years as an Institute, into the 21st Century

Celebrating Our 20th Anniversary


Browse photo galleries of past BIOMED events such as the Senior Design Showcase, Commencement, and more!

Event Gallery Archive