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Dr. Alisa Morss-Clyne

Morss ClyneAlisa

Associate Professor, Department of Mechanical Engineering and Mechanics
College of Engineering

Office: Alumni Engineering Labs 170C
Phone: 215.895.2366
Email: asm67@drexel.edu
Website: Vascular Kinetics Laboratory at Drexel University

Bio

Alisa Morss Clyne is an Associate Professor in the Mechanical Engineering and Mechanics Department and the principal investigator of the Vascular Kinetics Laboratory. She received a B.S. in Mechanical Engineering from Stanford University in 1996, a M.S. in Mechanical Engineering from the University of Cincinnati in 1999 and her PhD in Medical and Mechanical Engineering from Harvard-MIT Division of Health Sciences and Technology in 2006.

She currently serves as the Assistant Dean for Undergraduate Affairs for the College of Engineering.

Education

  • PhD, Medical and Mechanical Engineering, Massachusetts Institute of Technology (MIT), 2006
  • MS, Mechanical Engineering, University of Cincinnati, 1999
  • BS, Mechanical Engineering, Stanford University, 1996

Research Interests

Microfluidic devices to measure cell biochemical and mechanical responses; Auto-fluorescent mechanosensors; Flow and strain effects on endothelial cell – basement membrane interaction; Endothelial cell – smooth muscle cell interactions in diabetes; Plasma angiogenesis; advanced materials for accelerated wound healing; Nanoparticles for cardiovascular disease; sickle cell interactions with the vascular wall.

Publications

JOURNAL PUBLICATIONS

Mathew J, Morss Clyne A. Fibroblast growth factor-2 does not rescue plasminogen system activity or capillary-like tube formation in endothelial cells on glycated collagen. (In review)

Figueroa D, Kemeny S, Morss Clyne A. (In press) Glycated collagen decreased extracellular matrix fibronectin alignment in response to cyclic stretch via interruption of actin alignment. Journal of Biomechanical Engineering

Kemeny S, Figueroa D, Morss Clyne A. (2013) Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoSOne, 8(6): e66176.

Kemeny S, Cicalese S, Figueroa D, Morss Clyne A. (2013) Glycated collagen and altered glucose increase endothelial cell adhesion strength. Journal of Cellular Physiology, 228 (8): p. 1727-36.

Arjunan K, Morss Clyne A. (2013) A nitric oxide producing pin-to-hole spark discharge plasma enhances endothelial cell proliferation and migration. Plasma Medicine 1(3-4): 279-293. Patel N, Reisig K, Morss Clyne A. (2013) A computational model of fibroblast growth factor-2

binding in fluid flow. Annals of Biomedical Engineering 41(1): p. 154-171.
Morss Clyne A, FitzGerald GA. (2012) What great creation. Science Translational Medicine

4(154).
Yu M, Huang S, Yu KJ, Morss Clyne A. (2012) Dextran and polymer polyethylene glycol (PEG)

coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell

culture. International Journal of Molecular Sciences 13(5): p. 5554-70.
Arjunan K, Friedman G, Fridman A, Morss Clyne A. (2012) Non-thermal dielectric barrier

discharge plasma induces angiogenesis through reactive oxygen species. Journal of the Royal

Society Interface 9(66): p. 147-157.
Arjunan K, Morss Clyne A. (2011) Hydroxyl radical and hydrogen peroxide are primarily

responsible for dielectric barrier discharge plasma-induced angiogenesis. Plasma Processes

and Polymers 8: p. 1154-64
Kemeny S, Figueroa D, Andrews A, Barbee K, Morss Clyne A. (2011) Glycated collagen alters

endothelial cell actin alignment and nitric oxide release in response to fluid shear stress.

Journal of Biomechanics 44(10): p. 1927-35.
Figueroa D, Kemeny S, Morss Clyne A. (2011) Glycated collagen impairs endothelial cell

response to cyclic stretch. Cellular and Molecular Bioengineering 4 (2): p. 220-30. Kemeny S, Morss Clyne A. (2011) A simplified implementation of edge detection in MATLAB

is faster and more sensitive than Fast Fourier Transform for actin fiber alignment

quantification. Microscopy and Microanalysis 17: p. 156-166.
Dobrynin D, Arjunan KP, Fridman A, Friedman G, Morss Clyne A. (2011) Direct and

controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark

discharge (PHD) plasma. Journal of Physics D: Applied Physics 44: 075201. Buyukhatipoglu K, Morss Clyne A.(2011) Superparamagnetic iron oxide nanoparticles change

endothelial cell morphology and mechanics via reactive oxygen species formation. Journal of Biomedical Materials Research Part A 96A (1): p. 186-195.

                         
Morss Clyne A. Thermal processing of tissue engineering scaffolds. (2011) ASME Journal of Heat Transfer Special Issue on Advanced Thermal Processing 133(3): 034001.

Reisig K, Morss Clyne A. (2010) Fibroblast growth factor-2 binding to the endothelial basement membrane peaks at a physiologically relevant shear stress. Matrix Biology 29 (7): p. 586-93.

Buyukhatipoglu K, Chang R, Sun W, Morss Clyne A. (2010) Bioprinted Nanoparticles for Tissue Engineering Applications. Tissue Engineering 16 (4): p. 631-42.

Meghri NW, Donius AE, Riblett BW, Martin EJ, Morss Clyne A, and Wegst UGK. (2010) Directionally Solidified Biopolymer Scaffolds: Mechanical Properties and Endothelial Cell Responses. JOM 62 (7): p. 71-5.

Kalghatgi S, Friedman G, Fridman A, Morss Clyne A. (2010) Low dose non-thermal plasma treatment enhances endothelial cell proliferation through FGF-2 release. Annals of Biomedical Engineering 38 (3): p. 748-57.

Buyukhatipoglu K, Morss Clyne A. (2010) Controlled flame synthesis of αFe2O3 and Fe3O4 nanoparticles: effect of flame configuration, flame temperature and additive loading. Journal of Nanoparticle Research 12 (4): p. 1495-1508.

Buyukhatipoglu K, Jo W, Sun W, Morss Clyne A. (2009) The role of printing parameters and scaffold biopolymer properties in the efficacy of a new hybrid nano-bioprinting system. Biofabrication 1 (3): 035003.

Morss Clyne A, Edelman, ER. (2009) Vascular growth factor binding kinetics to the endothelial cell basement membrane, with a kinetics-based correction for substrate binding. Cytotechnology 60 (1): p. 33-44.

Buyukhatipoglu K, Miller TA, Morss Clyne A. (2009) Interaction of superparamagnetic, flame synthesized iron oxide nanoparticles with porcine aortic endothelial cells: toxicity, cellular uptake and proliferation studies. Journal of Nanoscience and Nanotechnology 9 (12): p. 6834-6843.

Morss Clyne, AS, Zhu, H, Edelman, ER. (2008) Elevated fibroblast growth factor-2 increases tumor necrosis factor-α induced endothelial cell death in high glucose. Journal of Cellular Physiology. 217: p. 86–92.

Morss AS, Edelman ER (2007). Glucose modulates basement membrane absorption of fibroblast growth factor-2 via alterations in endothelial cell permeability. Journal of Biological Chemistry. 282(19): p. 14635-14644.

Edelman ER, Seifert P, Groothuis A, Morss A, Bornstein D, Rogers C (2001). Gold-coated NIR stents in porcine coronary arteries. Circulation. 103(3): p. 429-434.

BOOK CHAPTERS

Urbano R, Morss Clyne A. Cell-substrate interactions. In Molecular and Cellular Biomechanics. Ed. Bradley Layton, Pan Stanford Publishing

Morss Clyne A. Reactive oxygen species in physiologic and pathologic angiogenesis. In Mechanical and Chemical Signaling in Angiogenesis. Ed. Cynthia Reinhart-King, Springer- Verlag Publishing

CONFERENCE PRESENTATIONS (* undergraduate)
Canver A, Urbano R, Morss Clyne A. The impact of matrix glycation and mechanics on

endothelial cell mechanotransduction, collective migration, and inflammatory response

(Invited talk) 2014 World Congress of Biomechanics
Morss Clyne A. Engineering the Mechanobiology Bridge: from Cells to Communities (Invited

talk) 2014 International Workshop on Multiscale Mechanobiology