J. Yasha Kresh, PhD Professor of Cardiothoracic Surgery, Medicine and Biomedical Engineering; Research Director, Cardiothoracic Surgery and Cardiovascular Biophysics Drexel University College of Medicine Office: 245 N. 15th Street, MS 111 Phone: 215.762.1703 Email: JYasha.Kresh@DrexelMed.edu Website: College of Medicine

Bio

Dr. Kresh is a professor in the Departments of Cardiothoracic Surgery and Medicine at Drexel University College of Medicine, and a professor in Drexel's School of Biomedical Engineering, Science and Health Systems. In addition he is research director of cardiothoracic surgery and cardiovascular biophysics.

• Pacing System and Method for Cardiac Pacing as a Function of Determined Myocardial Contractility: U.S. Patent #4,936,304
• Myocardial Contractility-Sensitive Pacer: French and German Patents #0244446 / 3673643
• Acoustic Blood Analyzer for Assessing Coagulation Status: U.S. Patent #(Pending)

Education

• MBME, PhD, RWJ Medical School and Rutgers University, 1976
• Research Internship, Artificial Intelligence in Medicine, Mt. Sinai School of Medicine, 1974-1976
• Postdoctoral Fellowship, Clinical Electrophysiology, Beth Israel Medical Center, 1976-1979

Research Interests

Cardiac repair and regeneration, tissue engineering, cardiovascular system dynamics, systems biology, cellular networks, cardiovascular engineering, telerobotics.

Publications

• "Pacing-Induced Cardiac Gap-Junction Remodeling"
  Matsushita, S., Tran, V.N., Pelleg, A., Wechsler, A.S., Kresh, J.Y.
  Amer. J. Therapeutics, Vol. 16, 224-230, 2009
• "Of Mice and Men (and Effects of Gene Silencing)"
  Wechsler AS, Kresh JY
  Circulation, Vol. 120, 1027-1028, 2009
• "Anti- and Proarrhythmic Effects of Cardiac Resynchronization Therapy: Point of View";
  DiPalma, J.R., Kutalek, S.P., Eisen, H., Kresh, J.Y., Pelleg, A.
  Amer. J. Therapeutics, Vol. 15, 190-195, 2008
• "Real-Time Monitoring of Adhesion and Aggregation of Platelets using Thickness Shear Mode (TSM) Sensor";
  Ergezen, E., Appel, M., Shah, P., Kresh, J.Y., Lec, R.M., Wootton, D.M  
  Biosens Bioelectron. Vol. 23, 575-82, 2007
• "Risk Stratification of Obstetric Patients Undergoing Spinal Anesthesia";
  Chamchad, D., Arkoosh, A.V., Horrow, J.C., Buxbaum, J.L., Izrailtyan, I.,  Nakhamchik, L., Hoyer, D., Kresh, J.Y.
  Anesthesia & Analgesia, Vol. 99, 1818-21, 2004
• Complex Systems Science in BioMedicine
  Deisboeck, T.S., Kresh, J.Y. (eds): Springer, New York, NY, USA. 2006
• "Cell replacement therapy: the functional importance of myocardial architecture and intercellular gap-junction distribution"
  Kresh, J.Y.
  J Thorac Cardiovasc Surg. Vol. 131, 1310-3, 2006
• "Physiologic and Hemodynamic Basis of Ventricular Assist Devices";
  Bolno, P.B., Kresh, J.Y.,
  Cardiology Clinics,  Vol. 21, 15-27, 2003
• "Cardiomyocyte-Mediated Contact Programs Human Mesenchymal Stem Cells to Express Cardiogenic Phenotype";
  Rangappa, S., Entwistle J.W., Wechsler, A.S., Kresh, J.Y.
  J Thorac and Cardiovas Surg.  Vol. 126, 124-132, 2003
• "A Novel approach to Robotic Cardiac Surgery Using Haptics and Vision"
  Kennedy, C.W., Hu, T., Desai, J.P., Wechsler, A. S., Kresh, J.Y.
  Cardiovascular Engineering:  An International Journal, Vol. 2 No. 1, 15-22 , 2002
• "Early detection of acute allograft rejection by linear and nonlinear analysis of heart rate variability"
  Izrailtyan I, Kresh JY, Morris RJ, Brozena SC, Kutalek SP, Wechsler AS.
  J Thorac Cardiovasc Surg. Vol. 120, 737-45, 2000