Dr. Frohbergh’s primary expertise focuses on bone and cartilage tissue engineering, orthopedic biomaterials, in vivo biocompatibility, small animal models for wound healing and cell/molecular biology techniques. He is proficient in biomechanical testing, histology, cell and molecular biology techniques, immunohistochemistry, scaffold fabrication methods, small animal surgery, microscopy and microCT analysis. He has experience with small animal performance analysis, drug and enzyme delivery from polymeric microspheres, and 3D printing for orthopedic implant designs.
Dr. Frohbergh has worked in academic exploratory research and aided in developing a number of projects throughout his career. He developed an electrospun, crosslinked chitosan/hydroxyapatite scaffold for non-load bearing cranial bone. He also developed the rodent osteochondral defect model and protocol used at the Icahn School of Medicine at Mt. Sinai. Prior to joining Exponent, Dr. Frohbergh worked as a postdoctoral fellow at Mt. Sinai in the department of Genetics and Genomic Sciences where he worked on articular cartilage repair using enzymatically treated cells in rodent models. He also worked on rare lysosomal storage disease mechanisms including mucopolysaccharidosis (MPS) and Farber disease. He was also involved in helping to develop the Mt. Sinai Institute of Technology (MSIT) and a mentor/assistant for the Design, Technology and Entrepreneurship (DTE) graduate classes. His thesis work was completed at Drexel University. Along with his research, Dr. Frohbergh was a teaching assistant for Tissue Engineering and the Biomaterials laboratory classes for three years, and a mentor for Drexel’s STAR, and Mini-Med summer programs.
Patents
- Frohbergh ME and Lelkes PI. New PCT Patent Appl. No. PCT/US11/55209, filed October 7, 2011 (Claims priority to U.S. Prov’l Appl. No. 61/390,918, filed October 7, 2010). Title: Electrospun Mineralized Chitosan Nanofibers Crosslinked With Genipin For Bone Tissue Engineering.