Kara received her bachelor's and master's degrees in biomedical engineering from Drexel University in 2007. She conducted her doctoral research in the design of semi-degradable hydrogels for the repair of articular cartilage in the Biomaterials and Drug Delivery Laboratory at Drexel and in the Shanghai Key Tissue Engineering Laboratory of Shanghai Jiao Tong University. After completing her PhD in 2010, when she received the award for Most Outstanding Doctoral Graduate: Most Promise to Enhance Drexel's Reputation, she conducted research in the design of scaffolds for bone tissue engineering as a Fulbright Fellow in the Biomaterials, Biodegradables, and Biomimetics (the 3Bs) Research Group at the University of Minho in Guimaraes, Portugal. She is currently conducting research in the design of immunomodularatory biomaterials, particularly for bone tissue engineering. Her research interests include cell-biomaterial interactionns, biomaterial design, and international engineering education.
- PhD, Biomedical Engineering, Drexel University, 2010
- BS/MS, Biomedical Engineering, Drexel University, 2007
Macrophage-biomaterial interactions, drug delivery systems, and chronic wound healing.
- Spiller KL, Nassiri S, Witherel CE, Anfang RR, Ng J, et al. Sequential delivery
of immunomodulatory cytokines to facilitate the M1-to-M2 transition of
macrophages and enhance vascularization of bone scaffolds. Biomaterials. 2015;
37:194-207. NIHMSID: NIHMS638428 PubMed [journal] PMID: 25453950, PMCID:
- Spiller KL, Freytes DO, Vunjak-Novakovic G. Macrophages modulate engineered human
tissues for enhanced vascularization and healing. Annals of biomedical
engineering. 2015; 43(3):616-27. NIHMSID: NIHMS636869 PubMed [journal] PMID:
25331098, PMCID: PMC4380684
- Microscale Technologies for Cell Engineering Applications
Pentecost A, Lurier E, Spiller, Kara L.
Singh A, Gaharwar A, editors. New York, NY: Springer; 2015. Nanoparticulate
systems for controlling monocyte/macrophage behavior
My Bibliography [book]
- Nassiri S, Zakeri I, Weingarten MS, Spiller KL. Relative Expression of
Proinflammatory and Antiinflammatory Genes Reveals Differences between Healing
and Nonhealing Human Chronic Diabetic Foot Ulcers. The Journal of investigative
dermatology. 2015; 135(6):1700-3. PubMed [journal] PMID: 25647438
- Spiller KL, Vunjak-Novakovic G. Clinical translation of controlled protein
delivery systems for tissue engineering. Drug delivery and translational
research. 2015; 5(2):101-15. NIHMSID: NIHMS448500 PubMed [journal] PMID:
25787736, PMCID: PMC4311895
- Biomaterials in Regenerative Medicine and the Immune System
Yu,Tony,, Tutwiler,Valerie,J, Spiller,Kara,L.
Santambrogio L, editor. Switzerland: Springer; 2015. The role of macrophages in
the foreign body response to implanted biomaterials424p.
My Bibliography [book]
- Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. Controlled
release of cytokines using silk-biomaterials for macrophage polarization.
Biomaterials. 2015; 73:272-83. NIHMSID: NIHMS725177 PubMed [journal] PMID:
26421484, PMCID: PMC4605898
- Spiller KL, Wrona EA, Romero-Torres S, Pallotta I, Graney PL, et al. Differential
Gene Expression in Human, Murine, and Cell Line-derived Macrophages upon
Polarization. Experimental cell research. 2015; PubMed [journal] PMID: 26500109
- Spiller KL, Anfang RR, Spiller KJ, Ng J, Nakazawa KR, et al. The role of
macrophage phenotype in vascularization of tissue engineering scaffolds.
Biomaterials. 2014; 35(15):4477-88. NIHMSID: NIHMS568909 PubMed [journal] PMID:
24589361, PMCID: PMC4000280
- A Tissue Regeneration Approach to Bone Repair
Nassiri S, Graney PL, Spiller KL.
Zreiqat H, Rosen V, editors. Switzerland: Springer; 2014. Manipulation of
macrophages to enhance bone repair and regeneration
My Bibliography [book]
- Gadjanski I, Yodmuang S, Spiller K, Bhumiratana S, Vunjak-Novakovic G.
Supplementation of exogenous adenosine 5'-triphosphate enhances mechanical
properties of 3D cell-agarose constructs for cartilage tissue engineering. Tissue
engineering. Part A. 2013; 19(19-20):2188-200. PubMed [journal] PMID: 23651296,
- Gadjanski I, Spiller K, Vunjak-Novakovic G. Time-dependent processes in stem
cell-based tissue engineering of articular cartilage. Stem cell reviews. 2012;
8(3):863-81. NIHMSID: NIHMS393758 PubMed [journal] PMID: 22016073, PMCID:
- Spiller KL, Liu Y, Holloway JL, Maher SA, Cao Y, et al. A novel method for the
direct fabrication of growth factor-loaded microspheres within porous
nondegradable hydrogels: controlled release for cartilage tissue engineering.
Journal of controlled release : official journal of the Controlled Release
Society. 2012; 157(1):39-45. PubMed [journal] PMID: 21930167
- Spiller KL, Holloway JL, Gribb ME, Lowman AM. Design of semi-degradable hydrogels
based on poly(vinyl alcohol) and poly(lactic-co-glycolic acid) for cartilage
tissue engineering. Journal of tissue engineering and regenerative medicine.
2011; 5(8):636-47. PubMed [journal] PMID: 21774087
- Spiller KL, Maher SA, Lowman AM. Hydrogels for the repair of articular cartilage
defects. Tissue engineering. Part B, Reviews. 2011; 17(4):281-99. PubMed
[journal] PMID: 21510824, PMCID: PMC3171151
- Holloway JL, Spiller KL, Lowman AM, Palmese GR. Analysis of the in vitro swelling
behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft
tissue replacement. Acta biomaterialia. 2011; 7(6):2477-82. PubMed [journal]
- Spiller KL, Laurencin SJ, Lowman AM. Characterization of the behavior of porous
hydrogels in model osmotically-conditioned articular cartilage systems. Journal
of biomedical materials research. Part B, Applied biomaterials. 2009;
90(2):752-9. PubMed [journal] PMID: 19274725
- Charlton DC, Peterson MG, Spiller K, Lowman A, Torzilli PA, et al.
Semi-degradable scaffold for articular cartilage replacement. Tissue engineering.
Part A. 2008; 14(1):207-13. NIHMSID: NIHMS96356 PubMed [journal] PMID: 18333818,
- Spiller KL, Laurencin SJ, Charlton D, Maher SA, Lowman AM. Superporous hydrogels
for cartilage repair: Evaluation of the morphological and mechanical properties.
Acta biomaterialia. 2008; 4(1):17-25. PubMed [journal] PMID: 18029236