Yinghui Zhong, PhD
School of Biomedical Engineering, Science and Health Systems
Office: Bossone 716
Yinghui Zhong received her BS degree in Materials Science and Engineering, and her MS degree in Biomedical Sciences and Biotechnology from Tsinghua University in Beijing China. Dr. Zhong received her PhD from Georgia Institute of Technology in Atlanta, Georgia. Her research interests are focused on (1) developing therapies to promote regeneration and scarless wound healing after spinal cord injury, using drug delivery, hydrogel scaffold, and stem cell strategies, (2) promoting neuroprotection and immunomodulation after spinal cord injury; and (3) developing multifunctional therapeutic nanoparticles for treating cardiovascular diseases.
- PhD, Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
- MS, Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
- BS, Materials Science and Engineering, Tsinghua University, Beijing, China
Neural tissue engineering, spinal cord repair, cardiovascular diseases, drug delivery, biomaterial scaffolds, stem cells, neural electrode/tissue interface, and surface modification.
- Zhang T, Nong J, Alzahrani N, Wang Z, Oh SW, Meier T, Yang DG, Ke Y, Zhong Y, Fu J.Self-Assembly of DNA-Minocycline Complexes by Metal Ions with Controlled Drug Release. ACS Applied Materials & Interfaces. In Press. Co-Corresponding Author.
- Ghosh B, Nong J, Wang Z, Urban MW, Heinsinger NM, Trovillion VA, Wright MC, Lepore AC, Zhong Y.A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. Neurobiology of Disease. 127:591-604. (2019)
- Kim T, Zhong Y, Giszter SF.Precise tubular braid structures of ultrafine microwires as neural probes: significantly reduced chronic immune response and greater local neural survival in rat cortex. IEEE Transactions on Neural Systems and Rehabilitation. In Press.
- Ghosh B, Wang Z, Nong J, Urban MW, Zhang Z, Trovillion VA, Wright MC, Zhong Y, and Lepore AC. Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. The Journal of Neuroscience. 38(26), 5982-5995. (2018). Co-Corresponding Author.
- Niu X, Zhang Z, and Zhong Y. Hydrogel loaded with self-assembled dextran sulfate-doxorubicin complexes as a delivery system for chemotherapy. Materials Science & Engineering. C. 77, 888-894. (2017).
- Shultz RB, Wang Z, Nong J, Zhang Z, and Zhong Y. Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury. Journal of Neural Engineering. 14(3), 036014. (2017).
- Wang Z, Nong J, Shultz RB, Zhang Z, Tom VJ, Ponnappan RK, and Zhong Y. Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury. Biomaterials, 112, 62-71, (2017).
- Shultz RB, and Zhong Y. Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury. Neural Regeneration Research. 12(5), 702-713. (2017).
- Zhang Z, Li Q, Han L, and Zhong Y. Layer-by-Layer Films Assembled from Natural Polymers for Sustained Release of Neurotrophin. Biomedical Materials, 10(5), 055006, (2015).
- Zhang Z, Nong J, and Zhong Y. Antibacterial, anti-inflammatory and neuroprotective layer-by-layer coatings for neural implants. Journal of Neural Engineering, 12(4), 046015, (2015).
- Zhang Z, Wang Z, Nong J, Nix CA, Ji HF, and Zhong Y. Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications. Biofabrication, 7(1), 015006, (2015).
- Zhang Z, Nix CA, Gerstenhaber JA, and Zhong Y. Calcium binding-mediated sustained release of minocycline from hydrophilic multilayer coatings targeting infection and inflammation for medical implants. PLoS One, 9(1), e84360, (2014).
- Karumbaiah L, Anand S, Thazhath R, Zhong Y, McKeon RJ, and Bellamkonda RV. Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition. Glia, 59(6), 981-996, (2011).
- Zhong Y, and Bellamkonda RV. Biomaterials for the central nervous system. Journal of the Royal Society Interface, 5(26), 957-975, (2008).
- Zhong Y, and Bellamkonda RV. Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. Brain Research, 1148, 15-27, (2007).
- Patz TM, Doraiswamy A, Narayan RJ, Menegazzo N, Kranz C, Mizaikoff B, Zhong Y, Bellamkonda R, Bumgardner JD, Elder SH, Walboomers XF, Modi R, and Chrisey DB. Matrix assisted pulsed laser evaporation of biomaterial thin films. Materials Science and Engineering: C, 27(3), 514-522, (2007).
- Patz TM, Doraiswamy A, Narayan RJ, He W, Zhong Y, Bellamkonda R, Modi R, and Chrisey DB. Three-dimensional direct writing of B35 neuronal cells, Journal of Biomedical Materials Research B, 78 (1), 124-130, (2006).
- Zhong Y, and Bellamkonda RV. Controlled release of alpha-MSH using nitrocellulose coatings for neural implants. Journal of Controlled Release, 106(3), 309-318, (2005).
- Zhong Y, McConnell GC, Ross JD, DeWeerth SP, and Bellamkonda RV. A Novel Dexamethasone-releasing, Anti-inflammatory Coating for Neural Implants. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, pp. 522-525, (2005). (win the Journal of Neural Engineering Award 2005)
- Zhong Y, Yu X, Gilbert RJ, and Bellamkonda RV. Stabilizing electrode-host interfaces: a tissue engineering approach. Journal of Rehabilitation Research and Development, 38(6), 627- 632, (2001).
- Gong H, Zhong Y, Li J, Gong Y, Zhao N and Zhang X. Studies on nerve cell affinity of chitosan-derived materials, Journal of Biomedical Materials Research, 52(2), 285-295, (2000).