Systems Pathophysiology of Organ Failure

Wednesday, May 7, 2025

2:30 PM-4:00 PM

BIOMED Seminar

Title:
Systems Pathophysiology of Organ Failure
    
Speaker:
Rajanikanth Vadigepalli, PhD
Professor and Vice Chair of Research
Department of Pathology and Genomic Medicine
Thomas Jefferson University

Details:
In this presentation, I will illustrate our systems pathobiology approach that brings together single cell scale transcriptomics, histopathology, physiology, metabolomics, bioinformatics, and computational modeling to unravel the mechanisms that underlie organ function, regeneration, and failure. We will draw on the recent results from ongoing projects studying neuromodulatory interventions into heart failure and metabolic reprogramming in alcohol-associated liver failure. In each case, we will highlight the development of patient-specific computational models as convergent platforms for integrating data and information from a variety of sources and enabling in silico trials.

Biosketch:
Raj Vadigepalli’s collaborative research program is driven by a convergence of systems engineering, computational modeling and simulation, bioinformatics, artificial intelligence, and single cell scale molecular omics, to identify and target key control points for intervention in disease. Ongoing international collaborations are targeting molecular mechanisms driving liver failure, neural circuits regulating heart failure, genotypes susceptible to developmental defects, and combination immunotherapy for cancer treatment. Recently, the group led the development of a unique high-resolution 3D map of the nervous system at the heart that is enabling neuromodulatory therapies for heart failure. Other recent research has led to patented microRNA-based molecular targets to prevent essential hypertension, molecular biomarkers for transplant donor liver assessment, and artificial intelligence based histopathological markers prostate cancer prognosis. Dr. Vadigepalli helped draft the guidelines adopted by the National Institutes of Health programs to promote and assess credible practice of modeling and simulation in biomedical sciences and healthcare. He recently served on an FDA panel on In Silico Technologies to develop recommendations for the use of computational evidence to accelerate clinical trials.

Raj Vadigepalli is currently a Professor and Vice Chair of Research in Pathology and Genomic Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. He received his bachelor’s in chemical engineering from the Indian Institute of Technology-Madras, and his PhD in chemical engineering from the University of Delaware, with specialization in systems and control engineering.

Contact Information

Carolyn Riley
cr63@drexel.edu