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Non-invasive Assessment of Tissue Hemodynamics and Metabolism with Optical Imaging

Wednesday, February 1, 2023

4:00 PM-5:30 PM

BIOMED Seminar

Non-invasive Assessment of Tissue Hemodynamics and Metabolism with Optical Imaging

Ulas Sunar, PhD
SUNY Empire Innovation Associate Professor
Department of Biomedical Engineering
Stony Brook University

For characterization of neurological disease and evaluation of intervention efficacy, there is a strong need for imaging modalities that can provide (bio)markers fast, frequently, and non-invasively. Diffuse optical imaging (DOI) is a promising tool for fulfilling this niche. By combining multiple techniques, DOI can simultaneously quantify functional and metabolic contrasts such as tissue blood flow, oxygenation, and oxygen/cellular metabolism, without the need for contrast agent administration, which is particularly attractive for early diagnosis and intraoperative evaluation in real time.  

In this talk, I will present the recent work of my lab related to neuroimaging applications. First, the results from Huntington’s disease and autism will be presented, demonstrating high blood flow and metabolic contrasts for the characterization of neurological diseases. Next, I will show recent results from the monitoring of traumatic brain injury in the neurointensive care unit (NeuroICU), demonstrating that non-invasive optical measure of blood flow has a high correlation with invasive neuromonitoring metrics.

I will conclude the talk by demonstrating recent technological developments for quantitative cerebral biomarkers with higher sensitivity to the human brain, thereby paving the way for fast clinical translation in NeuroICU settings and for general neuroimaging applications. Overall, portable and fast multimodal technology has allowed us to study tissue non-invasively in a variety of physiological contexts, including characterization and monitoring of neurological disorders in both preclinical and clinical settings.  

Ulas Sunar, PhD, is a SUNY Empire Innovation Associate Professor in the Department of Biomedical Engineering at Stony Brook University. He earned his PhD degree in the Department of Physics and Astronomy at the University of Pennsylvania, Philadelphia, in the research area of diffuse optical imaging for early assessment of the therapy response. He was previously a professor and the Ohio Research Scholar, and Endowed Chair in Medical Imaging at Wright State University.

Dr. Sunar's current research areas include the development and applications of quantitative optical imaging tools for neuroimaging and cancer imaging in preclinical and clinical settings. He is a recent NIH Brain Initiative awardee to develop innovative technology for neuromonitoring of patients with acute brain injuries in the NeuroICU.

Contact Information

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Papadakis Integrated Sciences Building (PISB), Room 120, located on the northeast corner of 33rd and Chestnut Streets.


  • Everyone