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Effect of Pulsed Electromagnetic Field (PEMF) on Mesenchymal Stem Cell (MSC) Chondrogenesis

Tuesday, November 26, 2019

11:00 AM-12:00 PM

BIOMED Special Seminar

Effect of Pulsed Electromagnetic Field (PEMF) on Mesenchymal Stem Cell (MSC) Chondrogenesis

Dinesh Parate, PhD
Postdoctoral Research Associate
National University of Singapore (NUS)

Mesenchymal stem cells (MSCs) are promising cell source for cartilage repair due to their ease of availability and high tendency to chondrogenic lineage commitment. This process has further been augmented by manipulating MSCs employing relevant biomaterials and/or physical stimulation. Pulsed Electromagnetic Field (PEMF) is one such non-invasive technology that has been implicated to enhance MSC chondrogenesis. We explored and characterized the effect of PEMF on MSCs undergoing chondrogenic differentiation. We demonstrated that MSCs were preferentially responsive to an electromagnetic efficacy window defined by field amplitude (2mT), duration (10mins) and frequency (15Hz) of exposure.

An in vivo study to validate the optimized PEMF parameters, on an osteochondral defect rat model, highlighted the constraints on PEMF-based therapeutic strategies aimed at promoting MSC chondrogenesis. The validated efficacy of our optimized low-amplitude PEMF regimens have clear clinical implications for future regenerative strategies for cartilage.

Dinesh Parate, PhD, received his doctorate from the National University of Singapore (NUS) in 2018. His research focused on developing PEMF-based stem cell therapy for cartilage repair. He broadened his research as a Research Fellow at the Department of Surgery, NUS, designing and developing a PEMF based cell-free (EVs) therapy for cartilage and muscle injuries.

Dr. Parate's research interests include combining stem cells and biomaterials with tissue engineering approaches in musculoskeletal research to establish novel cell and cell-free therapeutic strategies for tissue regeneration.

Contact Information

Ken Barbee

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