Elucidating Transcriptome Isoform Complexity Using Massive RNA-sequence Data

Wednesday, November 7, 2018

4:00 PM-5:30 PM

BIOMED Seminar

Title:
Elucidating Transcriptome Isoform Complexity Using Massive RNA-sequence Data

Speaker:
Yi Xing, PhD
Francis West Lewis Chair
Director, Center for Computational and Genomic Medicine, Children’s Hospital of Philadelphia
Professor, Department of Pathology and Laboratory Medicine, University of Pennsylvania

Details:
Mammalian cells produce a large number of distinct mRNA and protein isoforms from individual gene loci via alternative processing and modifications of RNA. The recent advent of the high-throughput RNA sequencing (RNA-seq) technology has provided a powerful tool for transcriptome-wide measurements of mRNA isoform complexity at an unprecedented resolution. Large consortium projects have generated RNA-seq data on tens of thousands of samples along with a wide variety of other genomic and phenotypic measurements. However, the use of these large-scale data in routine RNA-seq studies to detect patterns of expression and thereby discover new regulatory events has been limited. In this talk, I will discuss our recent efforts in developing and applying computational methods for elucidating transcriptome isoform complexity using massive RNA-seq datasets.

Biosketch:
Dr. Yi Xing is the Francis West Lewis Chair and Founding Director of the Center for Computational and Genomic Medicine at the Children’s Hospital of Philadelphia (CHOP), and Professor of Pathology and Laboratory Medicine at the University of Pennsylvania (Penn). Prior to his appointment at CHOP and Penn, Dr. Xing was a Professor of Microbiology, Immunology, and Molecular Genetics at UCLA, and served as Program Director of UCLA’s Bioinformatics Interdepartmental PhD Program.

Dr. Xing received his BS in Molecular and Cellular Biology and BE in Computer Science and Technology from the University of Science and Technology of China (2001). He completed his PhD training in Bioinformatics with Dr. Christopher Lee at UCLA (2001-2006), and his postdoctoral training with Drs. Wing Hung Wong and Matthew Scott at the Stanford University (2006-2007). Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His work has provided fundamental insights into the function, regulation, and evolution of post-transcriptional RNA processing in mammals. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.

Contact Information

Ken Barbee
215-895-1335
barbee@drexel.edu