Ming Xiao, PhD Professor School of Biomedical Engineering, Science and Health Systems Office: Bossone 210 Phone: 215.895.2690 Email: mx44@drexel.edu

Bio

Dr. Ming Xiao joined Drexel University in the School of Biomedical Engineering, Science and Health System in Summer 2012. Dr. Xiao received a PhD from the Baylor University in Biophysics. Dr. Xiao completed his Postdoctoral training at the University of Illinois, Urbana & Champaign, where he continued his studies in the molecular mechanism of muscle contraction. For the past decade, Dr. Xiao has been involved in nanogenomics, a field that aims to develop nanotechnologies in accelerating the genomic studies. More recently, Dr. Xiao was the director of advanced technology at Bionano Genomics, Inc, and one of the founding scientists of the company. Dr. Xiao's current research effort is split between technology development and biological applications. Technique development includes single molecule analysis of biomolecules (DNA, protein, RNA) under nanoplatform using advanced physical and chemical methods. One of such unique and innovative techniques, genome mapping, has been demonstrated in assisting the de novo assembly of sequencing reads from complex genomes, haplotype and structural variation analysis and comparative genomics.

Patents
Two issued patents and 10 patent applications.

Education

• Postdoctoral Fellow, University of Illinois at Urbana & Champaign, Urbana, IL, 1997 - 1999 
• PhD, Biophysics, Baylor University, Baylor Research Institute, Dallas, TX, 1997
• MS, Biomedical Engineering, Huazhong University of Science and Technology, China, 1991
• BA, Biomedical Engineering, Huazhong University of Science and Technology, China, 1988
  
  
  

Research Interests

Nanotechnology, single molecule detection, single molecule fluorescent imaging, genomics, genetics, genome mapping, DNA sequencing, DNA biochemistry, and biophysics.

Publications

• Lam, L.E., Hastie, A., Lin, C., Ehrlich, D., Das, S.K., Austin, M.D., Cao, H., Deshpande, P., Nagarajan, N., Xiao, M., Kwok, P.Y. (2012) Genome mapping for structural variation analysis and sequence assembly in nano-channel. Nature Biotechnology, 30 (8), 771-776.
• Baday, M., Hastie, A., Kudeki, D.E., Xiao, M., Selvin, P.R. (2012) Multi-color super-resolution DNA imaging for genetic analysis. Nano letters, 12 (7), 3861-3866.
• Xiao, M., Wan, E., Chu, C.,Hsueh, W. C., Cao, Y.,Kwok, P. Y.(2009). Direct determination of haplotypes from single DNA molecules. Nature Methods 6(3):199-201 
• Mak, A. C. Y., et al. (2016). Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays. Genetics 202(1): 351-362.
• McCaffrey, J., et al. (2016). CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis. Nucleic Acids Research 44(2): e11.