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Michael Neidrauer

Michael Neidrauer, PhD

Part-time Research Assistant Professor
School of Biomedical Engineering, Science and Health Systems

Office: Bossone 718
Phone: 215.895.2215
Email: mtn33@drexel.edu

Bio

Michael Neidrauer is an Assistant at Drexel University, School of Biomedical Engineering, Science and Health Systems, where his interdisciplinary research involves the development of non-invasive technologies for diagnosing and treating tissue damage. Previously, Michael was the co-founder and principal scientist at Zeomedix, a company developing novel technology for controlled delivery of nitric oxide to infected wounds, and the VP of Technology Development at Instadiagnostics, Inc., an early stage company developing a platform technology for blood diagnostics at the point of care. He holds a B.S. in Biological Engineering from Cornell University and a Ph.D. in Biomedical Engineering from Drexel University. Since completing his doctorate in 2010, Michael’s research has been supported by the NIH, NSF, CDMRP, US Army, and industry sources.

Michael’s primary research interest is to advance personalized medicine by combining noninvasive diagnostic technology with innovative therapeutic modalities. His current research is focused on developing methods that enable:

  1. Early detection of wounds, including deep tissue pressure injuries, using diffuse optical methods (DOMs) such as diffuse correlation spectroscopy (DCS) and diffuse near infrared spectroscopy (DNIRS).
  2. Objective assessment of chronic wound (e.g. diabetic ulcers, venous ulcers, pressure injuries) healing trajectories using DOMs.
  3. Accelerated healing of chronic wounds through safe, low frequency (20-100 kHz), low intensity (<100 mW/cm2) wearable ultrasound.

This thera-nostic approach is expected to give healthcare providers the ability to make agile treatment decisions, leading to individualized treatment approaches for chronic wound care as well as other medical conditions.

Education

  • PhD, Drexel University, Biomedical Engineering, 2010
  • BS, Cornell University, Biological Engineering, 2000

Research Interests

Biomedical optics, biomedical ultrasonics, biomedical instrumentation, diffuse near infrared spectroscopy (DNIRS), diffuse correlation spectroscopy (DCS), low frequency low intensity therapeutic ultrasound, wound healing, chronic wounds, deep tissue pressure injuries, diabetic ulcers, venous ulcers, microcirculatory blood flow, tissue oxygenation.

Publications

Selected Publications
·       A Bajpai, S Nadkarni, M Neidrauer, MS Weingarten, PA Lewin, KL Spiller, “Effects of nonthermal, noncavitational ultrasound exposure on human diabetic ulcer healing and inflammatory gene expression in a pilot study.” Ultrasound in Medicine and Biology, 2018; 44(9): 2043-2049. DOI: 10.1016/j.ultrasmedbio.2018.05.011, PMC 6105501
·       O Ngo, E Niemann, V Gunasekaran, P Sankar, M Putterman, A Lafontant, S Nadkarni, RA DiMaria-Ghalili, M Neidrauer, L Zubkov and M Weingarten, “Development of low frequency (20-100 kHz) clinically viable ultrasound applicator for chronic wound treatment.” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2018; DOI: 10.1109/TUFFC.2018.2836311.
·       D Diaz, A Lafontant, M Neidrauer, MS Weingarten, RA DiMaria-Ghalili, E Scruggs, J Rece, GW Fried, VL Kuzmin, L Zubkov, "Pressure injury prediction using diffusely scattered light," J. Biomed. Opt. 22(2), 025003 (2017)
·       VL Kuzmin, M Neidrauer, D Diaz, LA Zubkov, "Diffuse photon density wave measurements and Monte Carlo simulations," J Biomedical Optics. 2015 Oct 1;20(10):105006.
·       M Neidrauer, UK Ercan, A Bhattacharyya, J Samuels, J Sedlak, R Trikha, KA Barbee, MS Weingarten, SG Joshi, Antimicrobial efficacy and wound-healing property of a topical ointment containing nitric-oxide-loaded zeolites. Journal of medical microbiology, 2014. 63(Pt 2): p. 203-209.
·       MS Weingarten, JA Samuels, M Neidrauer, D Diaz, X Mao, J McGuire, JE McDaniel, L Jenkins, L Zubkov, ES Papazoglou, “Diffuse Near Infrared Spectroscopy Prediction of Healing in Diabetic Foot Ulcers: A Human Study and Cost Analysis”. Wound Repair and Regeneration, 20(6):911-7, 2012.
·       M Neidrauer, L Zubkov, MS Weingarten, K Pourrezaei, ES Papazoglou, “Near Infrared Wound Monitor Helps Clinical Assessment of Diabetic Foot Ulcers,” Journal of Diabetes Science and Technology, 4(4):792-798, 2010.
·       ES Papazoglou, L Zubkov, X Mao, M Neidrauer, N Rannou, MS Weingarten, “Image Analysis of Chronic Wounds for Determining Surface Area,” Wound Repair and Regeneration, 18:349-358, 2010.
·       MS Weingarten, M Neidrauer, A Mateo, X Mao, JE McDaniel, L Jenkins, S Bouraee, L Zubkov, K Pourrezaei, ES Papazoglou, “Prediction of Wound Healing in Human Diabetic Foot Ulcers by Diffuse Near Infrared Spectroscopy: A Pilot Study,” Wound Repair and Regeneration, 18:180-185, 2010.
·       E Papazoglou, C Sunkari, M Neidrauer, JF Klement, J Uitto, “Non-invasive Assessment of UV induced skin damage: Comparison of optical measurements to histology and MMP expression,” Photochemistry and Photobiology, 86(1): 138-145, 2010.
·       ES Papazoglou, M Neidrauer, L Zubkov, MS Weingarten, K Pourrezaei, “Non-invasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: A pilot human study,” Journal of Biomedical Optics, 14(6): 064032-064032-10, 2009.
·       MA Luedtke, ES Papazoglou, M Neidrauer, N Kollias, “Wavelength Effects on Contrast Observed With Reflectance In Vivo Confocal Laser Scanning Microscopy,” Skin Research and Technology, 15(4): 482-488, 2009.
·       M Neidrauer and E.S. Papazoglou, “Optical Non-invasive Characterization of Chronic Wounds,” in Bioengineering Research of Chronic Wounds: A Multidisciplinary Study Approach, A. Gefen, Editor. 2009, Springer Berlin Heidelberg. p. 381-404.
·       ES Papazoglou, MS Weingarten, L Zubkov, M Neidrauer, L Zhu, S Tyagi, and K Pourrezaei, "Changes in optical properties of tissue during acute wound healing in an animal model," Journal of Biomedical Optics, vol. 13, p. 044005, 2008.
·       MS Weingarten, ES Papazoglou, L Zubkov, L Zhu, M Neidrauer, G Savir, K Peace, JG Newby, K Pourrezaei, “Correlation of Near Infrared  Absorption and Diffuse Reflectance Spectroscopy Scattering (DRS) with Tissue Neovascularization and Collagen Concentration in a Diabetic Rat Wound Healing Model,”  Wound Repair and Regeneration, 16(2), p. 234–242, 2008.