Suresh Joshi, MD, PhD, MS

Part-time Research Professor
Nyheim Plasma Institute; School of Biomedical Engineering, Science and Health Systems

Office: School of Biomedical Engineering, Science and Health Systems
3122-24 Market Street
Bossone Research Center
Philadelphia, PA 19104
Phone: 215.895.1988
Email: sgj24@drexel.edu

Bio

Dr. Joshi is an adjunct professor at the Nyheim Plasma Institute, as well as Drexel's School of Biomedical Engineering, Science and Health Systems. He has a special interest in emerging bacterial infections, disinfection and sterilization, and biodefense.

Since 1987, Dr. Joshi has taught undergraduate, postgraduate and doctoral students and trained doctoral and postdoctoral fellows in research. He has been mentoring graduates and medical students, who now have successful careers in medicine, academia and the pharmaceutical industry. Since 2004, he has been a member of international mentoring program and minority mentoring program of American Society of Microbiology (ASM), and Infectious Disease Society of America (IDSA).

Subjects taught: Medical microbiology, pathology, parasitology, communicable diseases, hospital-acquired infections and infection control methods.
Visiting department faculty fellow: University of Rochester Medical Center, Rochester, N.Y.
Senior research fellowship and adjunct faculty: Thomas Jefferson University Medical College, Philadelphia, Pa.
Certification: Infection control, State of New York
Board eligible: American Board of Medical Microbiology
Postgraduate training (master's and doctoral): Medical microbiology and cellular biology
Medical training: Medical microbiology, as well as family physician. Practicing physician since 1986

Research

Research Fellows with Dr. Joshi
Bhaswati Sen, PhD; Rubina Narang (PhD student); Jennifer Scotti (rotation) and Peter Huh (MD students); Priya Dhagat, Brandon Fong and Rachel Figaro (MS students)

Dr. Joshi’s research areas are related to bacterial pathogenesis and biofilms, and wound infection and healing . He has extensive experience in the areas of antimicrobial resistance, nosocomial infection control strategies, and molecular and clinical epidemiology, drug development and animal infection models. He has also worked in the area of host cellular responses (with a special focus on apoptosis and mediation of NFkB and caspases) to bacterial pathogens and/or their virulence products. Joshi has developed several in vitro and in vivo assays, and has expertise in immunocytochemical (ICC) and immunohistochemical (IHC) detection systems and microscopies. He has initiated Surgical Infections Research (SIR) program at this institute, with a special emphasis to multi-drug resistant (MDR)- Acinetobacter and MRSA infection, runs biosafety level-2 plus (BSL2 +) bacteriology laboratory. The major current topics of research in Dr. Joshi's lab are:

- Carbapenem resistant-Acinetobacter baumannii: antibiotic resistance mechanisms, and pathogenesis of infection.
- Antimicrobial and anti-biofilm strategies: using atmospheric non-thermal plasma, novel antimicrobial sustained release, antimicrobial augmentation.
- Molecular diagnostic strategies for detection of multidrug-resistant bacterial pathogens and their virulence factors.
- Botulinum toxin: host responses, vaccine development, novel diagnostic techniques.

Clinical Trials
- Novel beta-lactamase inhibitors with carbapenems against complicated intra-abdominal infection.
- Clinical response and efficacy of novel beta-lactamase inhibitor in urinary tract infection therapeutic regime.
- Effect of novel antimicrobial solution and its clinical efficacy in the management of atopic dermatitis (being submitted).

Collaborations
- Nyheim Plasma Institute, Drexel University, Philadelphia
- Center for Botulism and Biodefense Research (CBBR), Thomas Jefferson University
- Institute of Molecular Medicine and Infectious Diseases, Dexel University College of Medicine
- School of Biomedical Engineering, Science and Health Systems, Drexel University
- KEM Hospital & Research Center, Pune, and University of Pune, Pune (India)
- Hadassah Hebrew University Medical Center, Jerusalem (Israel)

Education

PhD, Medical Microbiology, Faculty of Medicine, University of Pune, India
MS, Microbiology, University of Pune, India
MS, Biochemistry, University of Pune, India
MD, Marathwada University, India

Research Interests

Novel Infection Control Strategies, Wound Infection and Wound Healing, Surgical Infections, Biofilms, Infectious Skin Diseases, Biodefense, Translational Medicine, Molecular Diagnostics of Infectious diseases, Medical Devices and Clinical Trials, Medical and Molecular Microbiology, Epidemiology of Infectious Diseases, Plasma Medicine and Infection Control.

Publications

Selected Publications

(See all Suresh Joshi's publications in PubMed.)

"Involvement of multiple stressors induced by non-thermal plasma-charged aerosols during inactivation of airborne bacteria"
Vaze ND, Park S, Brooks AD, Fridman A, Joshi SG
PLOS ONE 12(2): e0171434 (2017)

"Atherosclerosis: the novel finding of biofilms and innate immune system activity within the plaques"
Allen HB, Boles J, Morales D, Ballal S, Joshi SG
Journal of Medical and Surgical Pathology 1(4): 135-140 (2016)

"Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution in Bacterial Inactivation"
Ercan UK. Smith J, Ji H-F, Brooks AD, Joshi SG
The Scientific Reports 6:20365, doi:10.1038/srep20365 (2016)

"Autoimmune Diseases of the Innate and Adaptive Immune System Including Atopic Dermatitis, Psoriasis, Chronic Arthritis, Lyme Diseases, and Alzheimer’s Disease"
Allen HB, Shaver CM, Etzler CA, Joshi SG
Immunochemistry and Immunopathology 1(2): 112 (2015)

“Studies on Acinetobacter baumannii involving multiple mechanisms of carbapenem resistance"
Sen B, Joshi SG
Journal of Applied Microbiology (2015)

“Phenotypic ESBL Detection in Acinetobacter baumannii: A Real Challenge” [PDF]
Litake GM, Ghole VS, Niphadkar KB, Joshi SG
American Journal of Infectious Diseases 11(3): 48-53, DOI: 10.3844/ajidsp.2015.48.53 (2015)

"Microarray analysis of transcriptomic response of Escherichia coli to nonthermal plasma-treated PBS solution"
Joshi SG, Yost A, Joshi SS, Addya S, Ehrlich GD, Brooks AD.
Advances in Bioscience and Biotechnology 6(2): 49-62 (2015)

"Inhibition of biofilms by non-thermal plasma treated novel solutions"
Ercan UK, Joshi SS, Yost A, Gogotsi N, O'Toole S, Paff M, Melchior E, Joshi SG.
Advances in Microbiology 4(16): 1188-1196 (2014)

"Calcium binding-mediated sustained release of minocycline from hydrophilic coatings targeting infection and inflammation"
Zhang Z, Nix CA, Ercan UK, Gerstenhaber JA, Joshi SG, Zhong Y.
PLoS One 9(1): e84360-68 (2014)

"The presence and impact of biofilm-producing staphylococci in atopic dermatitis"
Allen HB, Vaze NS, Choi C, Hailu T, Cusack CA, Joshi SG.
JAMA Dermatology, published online; doi:10.1001/jamadermatol.2013.8627 (Jan 22 , 2014)

"Patient demographics and characteristics of infection with carbapenem-resistant Acinetobacter baumannii in a teaching hospital from the United States"
Vaze ND, Emery CL, Hamilton RJ, Brooks AD, and Joshi SG
Advances in Infectious Diseases, 3(1):10-16 (2013)

"Nonequilibrium plasma-activated antimicrobial solutions are broad-spectrum and retain their efficacies for extended period of time"
Ercan UK, Wang H, Ji H, Fridman G, Brooks AD, and Joshi SG
Plasma Processes and Polymers, 10(6): 544-555 (2013)

"An analysis of the mechanisms that underlie absorption of botulinum toxin by the inhalation route"
Al-Saleem FH, Ancharski DM, Joshi SG, Elias MD, Singh A, Nasser Z, and Simposn LL
Infection and Immunity, 80(12): 4133-4142 (2012)

"Fulminating septicemia due to persistent pan-resistant community-acquired MBL (IMP1)-positive Acinetobacter baumannii"
Telang NV, Satpute MG, Dhakephalkar PK, Niphadkar KB, and Joshi SG
Indian Journal of Pathology and Microbiology, 54(1): 180-182 (2011)

"Modulation of botulinum toxin-induced changes in neuromuscular function with antibodies directed against recombinant polypeptides or fragments"
Joshi SG, Elias MD, Singh AK, Al-Saleem FH, Ancharski DM, Nasser Z, Takahashi T, and Simpson LL
Neuroscience, 179: 208-222 (2011)

"Non-thermal dielectric-barrier discharge (DBD) plasma-induced inactivation involves oxidative-DNA damage and membrane lipid peroxidation in Escherichia coli"
Joshi SG, Cooper M, Yost A, Paff M, Ercan UK, Fridman G, Friedman G, Fridman A, and Brooks AD
Antimicrobial Agents and Chemotherapy, 52: 1053-1062 (2011)

"Control of methicillin-resistant Staphylococcus aureus (MRSA) in planktonic form and biofilms: a biocidal efficacy study of non-thermal DBD-plasma"
Joshi SG, Paff M, Friedman G, Fridman G, Fridman A, and Brooks AD
American Journal of Infection Control, 38: 293-301 (2010)

"Localization of the sites and characterization of the mechanisms by which anti-light chain antibodies neutralize the actions of the botulinum holotoxin"
Takahashi T, Joshi SG, Al-Saleem FH, Ancharski D, Singh AK, Nisser Z, and Simpson LL
Vaccine, 27: 2616-2624 (2009)

"Rickettsia rickettsii-infection causes apoptotic death of cultured Cerebellar Granular Neurons"
Joshi SG, Kovacs AD
Journal of Medical Microbiology 56: 138-141 (2007)

"An initial assessment of the systemic Pharmacokinetics of Botulinum neurotoxin"
Ravichandran E, Gong Y, Al-saleem F, Ancharski D, Joshi SG, Simpson LL
Journal of Pharmacology & Experimental Therapeutics 318 (3): 1343-1351 (2006)

"The Role of Exoproteases in governing intraneuronal metabolism of Botulinum toxin"
Simpson LL, Maksymowych AB, Kouguchi H, DuBois G, Bora RS, Joshi S
The Protein Journal 24:155-165 (2005)

"NF-kB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and antiapoptotic proteins"
Joshi SG, Francis CW, Silverman DJ, Sahni SK
FEMS Microbiology Letters 234: 333-341 (2004)

"Nuclear factor-kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity"
Joshi SG, Francis CW, Silverman DJ, Sahni SK
Infection and Immunity 71 (7): 4127-4136 (2003)