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Adrian Shieh

Adrian Shieh, PhD

Teaching Professor
School of Biomedical Engineering, Science and Health Systems

Office: Bossone 710
Phone: 215.895.0358


Dr. Adrian Shieh received his BSE in Bioengineering from the University of Pennsylvania in 2000.  From 2000 to 2006, he conducted his PhD research in Bioengineering at Rice University with Prof. Kyriacos Athanasiou, studying how single chondrocytes responded to mechanical forces. From 2006 until 2010, he was conducting post-doctoral research at the École Polytechnique Fédérale de Lausanne in Lausanne, Switzerland, working with Prof. Melody Swartz to better understand the role of tumor-fibroblast interactions and fluid flow on invasive tumor behavior.  Since joining Drexel, Dr. Shieh’s focus has been on elucidating the molecular mechanisms underlying how cancer cells respond to interstitial fluid flow.


  • Post-doctoral Fellow, Laboratory of Lymphatic and Cancer Bioengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2006 - 2010
  • PhD, Bioengineering, Rice University, 2006
  • BSE, Bioengineering, University of Pennsylvania, 2000

Research Interests

3-D cell culture, cancer, cell and tissue engineering, extracellular matrix, fibroblasts, interstitial flow, mechanobiology, mechanotransduction, tumor invasion and metastasis, tumor microenvironment

Teaching Interests

Active learning, biomechanics, cell and molecular biology, cell and tissue engineering, problem-based learning, STEM education


Selected Publications

  • Shah AD, Bouchard MJ, Shieh AC. Interstitial fluid flow increases hepatocellular carcinoma cell invasion through CXCR4/CXCL12 and MEK/ERK signaling. PLOS One 10(11):e0142337, 2015.
  • Munson JM, Shieh AC. Interstitial fluid flow in cancer: implications for disease progression and treatment. Cancer Management Research 6:317-328, 2015.
  • Tchafa AM, Ta M, Reginato MJ, Shieh AC. EMT transition alters interstitial fluid flow-induced signaling in ERBB2-positive breast cancer cells. Molecular Cancer Research 13(4):755-764, 2015.
  • Chopra A, Patel A, Shieh AC, Janmey PA, Kresh JY. Alpha-catenin localization and sarcomere self-organization on N-cadherin adhesive patterns are myocyte contractility driven. PLOS One 7(10):e47592, 2012.
  • Tchafa AM, Shah AD, Wang S, Duong MT, Shieh AC. Three-dimensional cell culture model for measuring the effects of interstitial fluid flow on tumor cell invasion. Journal of Visualized Experiments (65), 2012.
  • Shieh AC. Biomechanical forces shape the tumor microenvironment. Annals of Biomedical Engineering 39(5):1379-1389, 2011.
  • Shieh AC, Swartz MA. Regulation of tumor invasion by interstitial fluid flow. Physical Biology 8(1):015012, 2011.
  • Shieh AC, Rozansky HA, Hinz B, Swartz MA. Tumor cell invasion is promoted by interstitial flow-induced matrix priming by fibroblasts. Cancer Research 71(3):790-800, 2011.
  • Shieh AC, Athanasiou KA. Dynamic compression of single cells. Osteoarthritis and Cartilage 15(3):328- 334, 2007.
  • Shieh AC, Koay EJ, Athanasiou KA. Strain-dependent recovery behavior of single chondrocytes. Biomechanics and Modeling in Mechanobiology 5(2-3):172-179, 2006.
  • Shieh AC, Athanasiou KA. Biomechanics of single zonal chondrocytes. Journal of Biomechanics 39(9):1595-1602, 2006.