Paul W. Brandt-Rauf, ScD, MD, DrPH Distinguished University Professor and Dean School of Biomedical Engineering, Science and Health Systems Office: Bossone 718-A Phone: 215.571.3723 Email: pwb35@drexel.edu

Bio

Dr. Paul W. Brandt-Rauf is Dean and Distinguished University Professor in the School of Biomedical Engineering, Science and Health Systems at Drexel University. He was previously Dean of the School of Public Health at the University of Illinois at Chicago (UIC), where he also held appointments as Professor of Environmental and Occupational Health Sciences in the School of Public Health, Professor of Medicine in the College of Medicine, Professor of Bioengineering in the College of Engineering, and Professor of Public Administration in the College of Urban Planning and Public Affairs.

Dr. Brandt-Rauf received his BS, MS, and ScD in Applied Chemistry and Chemical Engineering, his MD, and his MPH and DrPH in Environmental Sciences from Columbia University. He did post-graduate training in anatomic/environmental pathology, internal medicine, and occupational/environmental medicine, and he is certified by the American Board of Internal Medicine and the American Board of Preventive Medicine in Occupational Medicine. He is a Fellow of the American College of Physicians, the American College of Preventive Medicine, the American College of Occupational and Environmental Medicine, and the Royal Society of Medicine. After completing his post-graduate training, Dr. Brandt-Rauf joined the faculty at Columbia where he was most recently Professor and Chair of the Department of Environmental Health Sciences in the Mailman School of Public Health as well as Professor of Medicine, Earth and Environmental Engineering, and International and Public Affairs. He became Professor Emeritus at Columbia University upon assuming his position at UIC.

Academic Focus and Leadership
Under Dr. Brandt-Rauf's leadership as Chair of the Department of Environmental Health Sciences at Columbia, the department successfully expanded its academic programs (including a new MPH track in environmental health policy and an interdisciplinary PhD in environmental health sciences) approximately doubling student enrollment and successfully expanded its research programs with an approximate 6-fold increase in extramural funding. As a result, at the time of his departure the department was ranked as the second best in the country among departments of environmental health.

Under his leadership as Dean of the School of Public Health at UIC, the school has initiated new academic programs (including an undergraduate major in public health and an on- line version of the doctoral program in public health leadership for practicing professionals) resulting in significantly increased enrollment, new research programs (including a research mentorship program for junior faculty and pilot grants for the development of new research initiatives) resulting in significantly increased extramural funding, new service/practice programs (including a joint training program in public health with the Peace Corps, increased collaboration with local and state health agencies, and major expansions of the highly acclaimed programs for violence prevention in the inner city and AIDS prevention in Africa), and new development activities (with a tripling of the school’s endowment including the school’s first three endowed professorships).

Dr. Brandt-Rauf’s background in teaching has been extensive and has included both graduate and undergraduate experiences in numerous disciplines and schools at both Columbia and UIC. At Columbia, he personally mentored a number of master’s students, doctoral students, post-doctoral fellows, and occupational medicine residents in addition to teaching in a range of graduate courses in the School of Public Health and the College of Physicians and Surgeons as well as undergraduate and graduate courses in the School of Engineering and Applied Science and the School of International and Public Affairs; he also served as a faculty advisor for undergraduate engineering students in the Columbia chapter of Engineers Without Borders. At UIC, he has also mentored master’s students, doctoral students and post-doctoral fellows and has taught in graduate courses in the School of Public Health and the College of Medicine. In addition, as noted, he has established a new and innovative undergraduate liberal arts program in public health at UIC based on confluent, interdisciplinary, action-oriented, community-based participatory learning, as well as an on-line DrPH in public health leadership.

Dr. Brandt-Rauf’s background in research has been focused on environmental health, particularly the molecular biology and molecular epidemiology of environmental carcinogenesis. In addition to basic mechanistic research, his work has included epidemiologic studies of workplace and environmental carcinogens in the United States and around the world, as well as the development of new prophylactic/therapeutic interventions to mitigate the effects of these exposures. He has also written extensively on ethical, legal and social issues in occupational/environmental health policy and practice. He has authored over 240 journal articles and book chapters and edited several volumes on occupational/environmental health, and he is currently the Editor-in-Chief of the Journal of Occupational and Environmental Medicine.

Dr. Brandt-Rauf has been the recipient of several honors and awards including: the Allan Rosenfield Alumni Award for Excellence in Public Health from Columbia University; the Robert R.J. Hilker Award; the Harriet Hardy Award; the Robert A. Kehoe Award of Merit, the Meritorious Service Award and the Knudsen Lifetime Achievement Award of the American College of Occupational and Environmental Medicine; and a Certificate of Appreciation from the National Institute for Occupational Safety and Health. He has been featured in an award-winning film documentary (Blue Vinyl). He has been ranked among the top twenty Deans and Directors of Public Health and previously was regularly listed among the Top Doctors in Occupational Medicine and the Top Doctors in Preventive Medicine.

Dr. Brandt-Rauf is a former member of the Board of Directors of the American College of Occupational and Environmental Medicine and Engineers Without Borders and a current member of the Board of Directors of the Carcinogenesis Foundation. He has served as an advisor and consultant to industry (e.g., IBM, ExxonMobil, Rohm and Haas, General Mills), academia (e.g., Harvard University, the Karolinska Institute) and numerous governmental agencies (e.g., the World Health Organization, the Occupational Safety and Health Administration, the Department of Energy, the Environmental Protection Agency, the National Institute of Environmental Health Sciences, the National Institute for Occupational Safety and Health, the International Agency for Research on Cancer, the Pan American Health Organization Foundation, the Institute of Medicine of the National Academy of Sciences and the National Academy of Engineering).

Education

• DrPH, Columbia University, Environmental Sciences, 1987            
• MPH, Columbia University, Environmental Sciences, 1980
• MD, Columbia University, College of Physicians and Surgeons, 1979
• ScD, Columbia University, Applied Chemistry and Chemical Engineering, 1974
• MS, Columbia University, Applied Chemistry and Chemical Engineering, 1973
• BS, Columbia University, Applied Chemistry and Chemical Engineering, 1970

Research Interests

Environmental health, particularly the molecular biology and molecular epidemiology of environmental carcinogenesis, and protein engineering for the development of novel peptide therapies for the treatment and prevention of cancer.

Publications

Recent Articles
Heck, J.E., Nieves, J.W., Chen, Y., Parvez, F., Brandt-Rauf, P.W., Graziano, J.H., Slavkovich, V., Howe, G.R. and Ahsan, H., “Dietary Intake of Methionine, Cysteine, and Protein and Urinary Arsenic Excretion in Bangladesh, ” Environmental Health Perspectives, 117(1): 99-104 (2009).

Monaco, R., Rosal, R., Dolan, M.A., Pincus, M.R., Freyer, G. and Brandt-Rauf, P.W., “Conformational Effects of a Common Codon 751 Polymorphism on the C-Terminal Domain of the Xeroderma Pigmentosum D Protein, ” Journal of Carcinogenesis, 8(3): 93-97 (2009).

Li, Y., Karjalainen, A., Koskinen, H., Vainio, H., Pukkala, E., Hemminki, K. and Brandt- Rauf, P.W., “Serum Growth Factors in Asbestosis Patients, ” Biomarkers, 14(1): 61-66 (2009).

Li, Y., Marion, M.J., Zipprich, J., Santella, R.M., Freyer, G. and Brandt-Rauf, P.W., “Gene- Environment Interactions Between DNA Repair Polymorphisms and Exposure to the Carcinogen Vinyl Chloride, ” Biomarkers, 14(3): 148-155 (2009).

Li, Y., Long, C., Lin, G., Marion, M.J., Freyer, G., Santella, R.M. and Brandt-Rauf, P.W., “Effects of the XRCC1 Codon 399 Polymorphism on the Repair of Vinyl Chloride Metabolite-Induced DNA Damage, ” Journal of Carcinogenesis, 8(3): 108-112 (2009).

Grass, D.R., Ross, J.M., Family, F., Barbour, J., Simpson, H.J., Datta, S., Coulibaly, D., Slavkovich, V., Hernandez, J., Chen, Y., Graziano, J., Santella, R., Li, Y., Brandt-Rauf, P.W. and Chillrud, S.N., “Airborne Particulate-Metals in the NYC Subway: A Pilot Study to Assess the Potential for Health Impacts, ” Environmental Research, 110(1): 1-11 (2010).

Yazdi, E., Bowne, W., Adler, V., Sookraj, K., Wu, V., Shteyler, V., Patel, H., Oxbury, W., Brandt-Rauf, P.W., Zenilman, M., Michl, J. and Pincus, M., “Anti-Cancer Peptide, PNC-27, Adopts an HDM-2-Binding Conformation and Kills Cancer Cells by Binding to HDM-2 in Their Membranes, ” Proceedings of the National Academy of Sciences, U.S. A., 107(5): 1918- 1923 (2010).

Wang, W., Qiu, Y., Ji, F., Liu, J., Wu, F., Miao, W, Li, Y., Brandt-Rauf, P.W. and Xia, Z., “Genetic Polymorphisms in Metabolizing Enzymes and Susceptibility of Chromosomal Damage Induced by Vinyl Chloride Monomer in a Chinese Worker Population, ” Journal of Occupational and Environmental Medicine, 52(2): 163-168 (2010).

Parvez, F., Chen, Y., Brandt-Rauf, P.W., Slavkovich, V., Argos, M., Islam, T., Ahmed, A., Hassan, R., Balac, O., Graziano, J.H. and Ahsan, H., “A Prospective Study of Arsenic Exposure and Respiratory Symptoms in Bangladesh: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS), ” Thorax, 65(6): 528-533 (2010).

Heck, J.E., Nieves, J.W., Chen, Y., Parvez, F., Brandt-Rauf, P.W., Howe, G.R. and Ahsan, H., “Protein and Amino Acid Intakes in Rural Areas of Bangladesh, ” Food and Nutrition Bulletin, 31(2): 206-213 (2010).

Wang, Q., Ji, F., Sun, Y., Qiu, Y.L., Wang, W., Wu, F., Miao, W.B., Li, Y., Brandt-Rauf, P.W. and Xia, Z.L., “Genetic Polymorphisms of XRCC1, HOGG1 and MGMT and Micronucleus Occurrence in Chinese Vinyl Chloride-Exposed Workers, ” Carcinogenesis 31(6): 1068-1073 (2010).

Zipprich, J., Terry, M.B., Brandt-Rauf, P.W., Freyer, G.A., Liao, Y., Agrawal, M., Gurvich, I., Senie, R. and Santella, R.M., “XRCC1 Polymorphisms, DNA Repair Phenotype and Breast Cancer Risk from the New York Site of the Breast Cancer Family Registry: A Family-Based Case-Control Study, ” Journal of Carcinogenesis 9(1): 4-10 (2010).

Brandt-Rauf, P.W., “Global Environmental Justice Beyond Copenhagen: Footprints, Fairness and the Future of the Planet, ” Forum on Public Policy, Fall 2010(3): e1-9 (2010).

Brandt-Rauf, S.I., Brandt-Rauf, E., Gershon, R., Li, Y. and Brandt-Rauf, P.W., “Genes, Jobs and Justice: Occupational Medicine Physicians and the Ethical, Legal and Social Issues of Genetic Testing in the Workplace, ” Ethics & Medicine – An International Journal of Bioethics 27(1): 51-61 (2011).

229. Brandt-Rauf, S.I., Brandt-Rauf, E., Gershon, R. and Brandt-Rauf, P.W., “The Differing Perspectives of Workers and Occupational Medicine Physicians on the Ethical, Legal and Social Issues of Genetic Testing in the Workplace, ” New Solutions – A Journal of Environmental and Occupational Health Policy 21(1): 89-102 (2011).

228. Tooker, B.C., Newman, L.S., Bowler, R.P., Karjalainen, A., Oksa, P., Vainio, H., Pukkala, E. and Brandt-Rauf, P.W., “Proteomic Detection of Cancer in Asbestosis Patients Using SELDI-TOF Discovered Serum Protein Biomarkers, ” Biomarkers 16(2): 181-191 (2011).

Allen, H., Mendonsa, R., O’Brien, P. and Brandt-Rauf, P.W., “Sustainable Healthcare Reform: Toward a National Strategy Built on Recent Employer Health and Productivity Successes, ” Journal of Health and Productivity 5(2): 2-12 (2011).

Brandt-Rauf, P.W., Li, Y., Long, C., Monaco, R., Kovvali, G. and Marion, M.J., “Plastics and Carcinogenesis: The Example of Vinyl Chloride, ” Journal of Carcinogenesis 11(5): 50- 60 (2012).

Jiao, J., Feng, N.N., Li, Y., Sun, Y., Yao, W., Wang, W., Zhang, G.H., Sun, S.Y., Tan, H.S., Wang, Q., Zhu, Y., Li, Y., Brandt-Rauf, P.W. and Xia, Z.L., “Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China, ” Journal of Occupational Health 54(4): 263-270 (2012).

Wang, Q., Tan, H.S., Ma, X.M., Sun, Y., Feng, N.N., Zhou, L.F., Ye, Y.J., Zhu, Y.L., Li, Y.L., Brandt-Rauf, P.W., Tang, N.J. and Xia, Z.L., “Estimation of the Benchmark Dose for Micronucleus Occurrence in Chinese Vinyl Chloride-Exposed Workers, ” International Journal of Hygiene and Environmental Health 216(1): 76-81 (2013).

Wu, F., Liu, J., Qiu, Y.L., Wang, W., Zhu, S.M., Sun, P., Miao, W.B., Li, Y., Brandt-Rauf, P.W. and Xia, Z.L., “Correlation of Chromosome Damage and Promoter Methylation Status of the DNA Repair Genes MGMT and hMLH1 in Chinese Vinyl Chloride Monomer (VCM) -Exposed Workers, ” International Journal of Occupational Medicine and Environmental Health 26(1): 1-10 (2013).

Crowley, K.A., Myers, R., Magda, L.A., Morse, S.S., Brandt-Rauf, P.W. and Gershon, R.R. M., “Prevalence and Factors Associated with 2009-2011 Influenza Vaccination at a University Medical Center, ” American Journal of Infection Control 41(9): 824-830 (2013).

Wang, Q., Tan, H.S., Zhang, F., Sun, Y., Feng, N.N., Zhou, L.F., Ye, Y.J., Zhu, Y.L., Li, Y.L., Brandt-Rauf, P.W., Shao, H. and Xia, Z.L., “Polymorphisms in BER and NER Pathway Genes: Effects on Micronucleus Frequencies among Vinyl Chloride-Exposed Workers in Northern China, ” Mutation Research 754(1-2): 7-14 (2013).

Crowley, K.A., Myers, R., Riley, H.E. M., Morse, S.S., Brandt-Rauf, P.W. and Gershon, R.R. M., “Using Participatory Action Research to Identify Strategies to Improve Pandemic Vaccination, ” Disaster Medicine and Public Health Preparedness 7(4): 424-430 (2013).

Dinnen, R.D., Mao, Y., Qui, W., Cassai, N., Slavkovich, V.N., Nichols, G., Su, G., Brandt-Rauf, P.W. and Fine, R.L., “Re-Directing Apoptosis to Aponecrosis Induces Increased Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels and VDAC, ” Molecular Cancer Therapeutics 12(2): 2792-2803 (2013).

Li, Y., Feng, N., Zhang, G.H., Wang, Q., Hao, Y.H., Nanzhang, Y., Long, C., Li, Y., Brandt-Rauf, P.W. and Xia, Z.L., “Polymorphisms in the p53 Pathway Genes and Micronucleus Occurrence in Chinese Vinyl Chloride-Exposed Workers, ” International Journal of Occupational Medicine and Environmental Health 26(6): 825-836 (2014).

Feng, N., Li, Y., Long, C., Xia, Z.L. and Brandt-Rauf, P.W., “Effects of DNA Repair Gene Polymorphisms on DNA Damage in Human Lymphocytes Induced by a Vinyl Chloride Metabolite, ” Biomarkers 19(4): 281-286 (2014).

Brandt-Rauf P. W., Borak, J., Deubner, D.C. and the ACOEM Task Force on Genetic Screening, “Genetic Screening in the Workplace, ” Journal of Occupational and Environmental Medicine 57(3): e17-18 (2015).

Lenihan P., Welter, C., Brandt-Rauf, P.W., Neuberger, B., Pinsker E., Petros, M. and Risley, K., “The UIC DrPH Program: An Innovative Approach to Doctoral-Level Practice Leadership Development, American Journal of  Public Health 105(S1): S55-59 (2015).

Feng, N.N., Zheng, G., Hao, Y., Li, Y., Xu, Y.D., Xu, X., Zhang, G., Wang, J., Li, Y.L., Brandt-Rauf, P.W. and Xia, Z.L., “Polymorphisms in Apoptotic Genes and Micronucleus Occurrence in Vinyl Chloride-Exposed Workers in China, ” submitted to Environmental and Molecular Mutagenesis.

Book Chapters
Brandt-Rauf, P.W. and Weinstein, I.B., “Environment and Disease, ” in Handbook of Health, Health Care and the Health Professions, D. Mechanic (ed.), Free Press, New York, pp. 240- 278 (1983).

Perera, F., Jeffrey, A., Santella, R.M., Brenner, D., Mayer, J., Latriano, L., Smith, S., Young, T.L., Tsai, W.Y., Hemminki, K. and Brandt-Rauf, P.W., “Biomarkers in Biomonitoring and Epidemiology of Complex Exposures, ” in Complex Mixtures and Cancer Risk, H. Vainio, M. Sorsa and A. J. McMichael (eds.), IARC Scientific Publication No. 104, International Agency for Research on Cancer, Lyon, pp. 164-180 (1990).

Perera, F.P., Santella, R.M., Brandt-Rauf, P.W., Kahn, S., Jiang, W., Tang, D. and Mayer, J., “The Role of Molecular Epidemiology in Cancer Prevention, ” in Xenobiotics and Cancer: Implication for Chemical Carcinogenesis and Cancer Chemotherapy, L. Ernster, H. Esumi, Y. Fujii, H.V. Gelboin, R. Kato and T. Sugimura (eds.), Japan Scientific Societies Press, Tokyo, pp. 339-350 (1991).

Perera, F.P., Santella, R., Brandt-Rauf, P.W., Kahn, S., Jiang, W. and Mayer, J., “Molecular Epidemiology of Lung Cancer, ” in Origins of Human Cancer: A Comprehensive Review, J. Brugge, T. Curran, E. Harlow and F. McCormick (eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, pp. 219-236 (1991).

Schwarz-Miller, J., Rom, W.N. and Brandt-Rauf, P.W., “Polycyclic Aromatic Hydrocarbons, ” in Environmental and Occupational Medicine, 2nd edition, W.N. Rom (ed.), Little Brown, Boston, pp. 873-879 (1992).

Goldstein, M.D. and Brandt-Rauf, P.W., “Bladder Carcinogens and Surveillance, ” in Environmental and Occupational Medicine, 2nd edition, W.N. Rom (ed.), Little Brown, Boston, pp. 881-886 (1992).

Brandt-Rauf, P.W., Marion, M.J. and DeVivo, I., “Mutant p21 Protein as a Biomarker of Chemical Carcinogenesis in Humans, ” in Biomarkers and Occupational Health: Progress and Perspectives, M.L. Mendelsohn, J.P. Peeters and M. J. Normandy (eds.), National Academy of Sciences, Washington, pp. 163-173 (1995).

Pincus, M.R., Brandt-Rauf, P.W. and Nostro, D., “Cell Biology and Early Tumor Detection, ” in Clinical Diagnosis and Management by Laboratory Methods, 19th edition, J.B. Henry (ed.), W.B. Saunders, Philadelphia, pp. 310-321 (1996).

Brandt-Rauf, P.W. and Brandt-Rauf, S.I., “Biomarkers: Scientific Advances and Societal Implications, ” in Genetic Secrets: Protecting Privacy and Confidentiality in the Genetic Era, M.A. Rothstein (ed.), Yale University Press, New Haven, pp. 184-196 (1997).

10. Brandt-Rauf, P.W. and Brandt-Rauf, S.I., “Ethical Issues in Occupational Health and Safety Research, ” in Encyclopedia of Occupational Health and Safety, J.M. Stellman (ed.), International Labor Organization, Geneva, pp. 19.7-19.9 (1997).

Li, Y., Asherova, M., Marion, M.J. and Brandt-Rauf, P.W., “Mutant Oncoprotein Biomarkers in Chemical Carcinogenesis, ” in Medical and Workplace Applications of Biomarkers, M.L. Mendelsohn, L.C. Mohr and J. P. Peeters (eds.), Joseph Henry Press, Washington, pp. 345- 353 (1998).

Brandt-Rauf, P.W., “Biomarkers, ” in Public Health and Preventive Medicine, 14th edition, R.B. Wallace (ed.), Appleton and Lange, Stamford, pp. 445-446 (1998).

Goldstein, M.D., Griffin, P.D. and Brandt-Rauf, P.W., “Bladder Carcinogens, ” in Environmental and Occupational Medicine, 3rd edition, W.N. Rom (ed.), Lippincott-Raven, Philadelphia, pp. 857-863 (1998).

Schwarz-Miller, J., Goldstein, M.D. and Brandt-Rauf, P.W., “Polycyclic Aromatic Hydrocarbons, ” in Environmental and Occupational Medicine, 3rd edition, W.N. Rom (ed.), Lippincott-Raven, Philadelphia, pp. 1261-1267 (1998).

Brandt-Rauf, P.W., Do, T., Weinberg, M.D. and Smith S. J., “Growth Signal Transduction Proteins as Biomarkers of Occupational Exposures, ” in Human Monitoring After Environmental and Occupational Exposure to Chemical and Physical Agents: Proceedings of the NATO Advanced Study Institute, D. Anderson, A.E. Karakaya and R. J. Sram (eds.), IOS Press, Amsterdam, pp. 208-212 (1998).

Brandt-Rauf, P.W., Luo, J.C., Cheng, T.J., Du, C.L., Wang, J.D. and Marion, M.J., “Mutant Oncoprotein Biomarkers of Vinyl Chloride Exposure: Application to Risk Assessment, ” in Human Monitoring After Environmental and Occupational Exposure to Chemical and Physical Agents: Proceedings of the NATO Advanced Study Institute, D. Anderson, A.E. Karakaya and R. J. Sram (eds.), IOS Press, Amsterdam, pp. 243-248 (1998).

Pincus, M.R., Brandt-Rauf, P.W., Koslosky, W. and Apruzzese, W., “Oncoproteins and Early Tumor Detection, ” in Clinical Diagnosis and Management by Laboratory Methods, 20th Edition, J.B. Henry (ed.), W.B. Saunders, Philadelphia, pp. 1344-1354 (2001).

Pincus, M.R., Brandt-Rauf, P.W. and Bluth, M.H., “Oncoproteins and Early Tumor Detection, ” in Henry’s Clinical Diagnosis and Management by Laboratory Methods, 21st Edition, R.A. McPherson and M. R. Pincus (eds.), Elsevier-Saunders, Philadelphia, pp. 1367-1380 (2007).

Pincus, M.R., Brandt-Rauf, P.W., Bluth, M.H. and Bowne, W.B., “Oncoproteins and Early Tumor Detection, ” in Henry’s Clinical Diagnosis and Management by Laboratory Methods, 22nd Edition, R.A. McPherson and M. R. Pincus (eds.), Elsevier-Saunders, Philadelphia, pp. 1400-1414 (2011).

Brandt-Rauf, P.W., Li, Y., Long, C. and Monaco, R., “The Molecular Epidemiology of DNA Repair Polymorphisms in Carcinogenesis, ” in DNA Repair- New Research Directions, C. Chen (ed.), InTech, Rijeka, pp. 579-595 (2013).

Klein-Rosenthal, J., Sclar, E.D., Kinney, P.L., Knowlton, K., Crauderueff, R. and Brandt-Rauf, P.W., “Links Between the Built Environment, Climate and Population Health: Interdisciplinary Environmental Change Research in New York City, ” in Urban Landscape: Critical Concepts in the Built Environment, Vol. IV, A. Berrizbeitia (ed.), Routledge, London, pp. 71-94 (2015).