Publications

2019

• Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms.
  Sao K, Jones TM, Doyle AD, Maity D, Schevzov G, Chen Y, Gunning PW, Petrie RJ.
  Mol Biol Cell;30(10):1170-1181
• Hydraulic control of mammalian embryo size and cell fate.
  Chan CJ, Costanzo M, Ruiz-Herrero T, Mönke G, Petrie RJ, Bergert M, Diz-Muñoz A, Mahadevan L, Hiiragi T.
  Nature;571(7763):112-116
• YAP and TAZ regulate cell volume.
  Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX.
  J Cell Biol;218(10):3472-3488
• The Drosophila chromodomain protein Kismet activates steroid hormone receptor transcription to govern axon pruning and memory in vivo.
  Latcheva NK, Viveiros JM, and Marenda DR.
  iScience 16;16:79-93
• Extramacrochaete promotes branch and bouton number via the sequestration of Daughterless in the cytoplasm of neurons.
  Waddell EA, Viveiros JM, Robinson EL, Sharoni M, Latcheva NK, and Marenda DR.  
  Developmental Neurobiology;79(8):805-818
• Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition
  Priyalakshmi Panikker, Song-Jun Xu,* Haolin Zhang,* Jessica Sarthi, Mariah Beaver, Avni Sheth, Sunya Akhter, Felice Elefant
  The Journal of Neuroscience;38(19):4569 – 4583 • 4569
• Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner
  Nakos K, Radler MR, Spiliotis ET 
  Mol Biol Cell;30(23):2913-2928
• Spiliotis ET A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission 
  Karasmanis EP, Hwang D, Nakos K, Bowen JR, Angelis D 
  Curr Biol;29(13):2174-2182.e7
  
• Spiliotis ET Regulation of microtubule plus end dynamics by septin 9
  Nakos K, Rosenberg M
  Cytoskeleton; 76(1): 83–91

2018

• Epigenetic crosstalk: Pharmacological inhibition of HDACs can rescue defective synaptic morphology and neurotransmission phenotypes associated with loss of the chromatin reader Kismet.
  Latcheva NK, Viveiros JM, Waddell EA, Nguyen PTT, Liebl FLW, Marenda DR.
  Molecular and Cellular Neuroscience;87:77-85 
• HSP-4/BiP expression in secretory cells is regulated by a lineage-dependent differentiation program and not by the unfolded protein response.
  Zha J, Alexander-Floyd J, Gidalevitz T.
  bioRxiv.
• Regulation of microtubule plus end dynamics by septin 9.
  Nakos K, Rosenberg M, Spiliotis ET.
  Cytoskeleton (Hoboken).
• On the Measurement of Energy Dissipation of Adhered Cells with the Quartz Microbalance with Dissipation Monitoring.
  Monemian Esfahani A, Zhao W, Chen JY, Huang C, Xi N, Xi J, Yang R.
  Anal Chem;90(17):10340-9.
• Epigenetic crosstalk: Pharmacological inhibition of HDACs can rescue defective synaptic morphology and neurotransmission phenotypes associated with loss of the chromatin reader Kismet.
  Latcheva NK, Viveiros JM, Waddell EA, Nguyen PTT, Liebl FLW, Marenda DR.
  Mol Cell Neurosci;87:77-85.
• Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin.
  Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET.
  Dev Cell;46(4):518-24.
• Perfusion double-channel micropipette probes for oxygen flux mapping with single-cell resolution.
  Gao Y, Li B, Singhal R, Fontecchio A, Pelleg B, Orynbayeva Z, Gogotsi Y, Friedman G.
  Beilstein J Nanotechnol;9:850-60.
• Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond.
  Chen JY, Penn LS, Xi J.
  Biosens Bioelectron;99:593-602.

2017

• Fluid Shear Stress and Fibroblast Growth Factor-2 Increase Endothelial Cell-Associated Vitronectin.
  Mathew JG, Basehore S, Clyne AM.
  Appl Bionics Biomech. 2017:9040161.

• Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability.
  Urbano RL, Furia C, Basehore S, Clyne AM.
  Biophys J. 113(3):645-655.
• Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers.
  Meng Z, Le Marchand S, Agnani D, Szapacs M, Ellens H, Bentz J.
  Drug Metab Dispos. 45(2):145-151.
• Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats.
  Manohar A, Foffani G, Ganzer PD, Bethea JR, Moxon KA.
  Elife. 6. pii: e23532.
• Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.
  Xu S, Panikker P, Iqbal S, Elefant F.
  PLoS One. 11(7):e0159623.
• Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury.
  Shultz RB, Wang Z, Nong J, Zhang Z, Zhong Y.
  J Neural Eng. 14(3):036014.
• Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury.
  Wang Z, Nong J, Shultz RB, Zhang Z, Kim T, Tom VJ, Ponnappan RK, Zhong Y.
  Biomaterials. 112:62-71.
• Activating the nuclear piston mechanism of 3D migration in tumor cells.
  Petrie RJ, Harlin HM, Korsak LI, Yamada KM.
  J Cell Biol. 216(1):93-100.
• Vascular Endothelial-Breat Epithelial Cell Coculture Model Created from 3D Cell Structures. Swaminathan S, Ngo O, Basehore S, Clyne AM.
  ACS Biomaterials Science & Engineering;3(11):2999-3006.
• Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.
  Gomes C, Lee SJ, Gardiner AS, Smith T, Sahoo PK, Patel P, Thames E, Rodriguez R, Taylor R, Yoo S, Heise T, Kar AN, Perrone-Bizzozero N, Twiss JL.
  J Cell SCI;130(21):3650-62.
• Quantification of Multicellular Organization, Junction Integrity, and Substrate Features in Collective Cell Migration.
  Canver AC, Morss Clyne A.
  Microsc Microanal;23(1)22-33.

2016

• A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.
  Klabonski L, Zha J, Senthilkumar L, Gidalevitz T.
  PLoS Genet. 12(12):e1006450.
• Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.
  Dolat L, Spiliotis ET.
  J Cell Biol. 214(5):517-27.
• Fluorescence microscopy of actin- and microtubule-associated septins in mammalian cells.
  Spiliotis ET, Karasmanis EP, Dolat L.
  Methods Cell Biol. 136:243-68.
• Dynamic Changes in Local Protein Synthetic Machinery in Regenerating Central Nervous System Axons after Spinal Cord Injury.
  Sachdeva R, Farrell K, McMullen MK, Twiss JL, Houle JD.
  Neural Plast. 2016:4087254.
• Deposition of Colloidal Drops Containing Ellipsoidal Particles: Competition between Capillary and Hydrodynamic Forces.
  Kim DO, Pack M, Hu H, Kim H, Sun Y.
  Langmuir. 32(45):11899-11906.
• A Facile Approach to Functionalize Cell Membrane-Coated Nanoparticles.
  Zhou H, Fan Z, Lemons PK, Cheng H.
  Theranostics. 6(7):1012-22.
• Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.
  D'Rozario M, Zhang T, Waddell EA, Zhang Y, Sahin C, Sharoni M, Hu T, Nayal M, Kutty K, Liebl F, Hu W, Marenda DR.
  Cell Rep. 15(2):386-97.
• Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy.
  Zhou H, Fan Z, Deng J, Lemons PK, Arhontoulis DC, Bowne WB, Cheng H.
  Nano Lett. 16(5):3268-77.
• Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport.
  Bai X, Karasmanis EP, Spiliotis ET.
  Mol Biol Cell. 27(6):897-906.
• An inverted dielectrophoretic device for analysis of attached single cell mechanics.
  Lownes Urbano R, Morss Clyne A.
  Lab Chip. 16(3): 561–573.
• Endothelial directed collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions.
  Canver AC, Ngo O, Urbano RL, Clyne AM.
  J Biomech. 49(8):1369-1380.
• Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.
  Xu S, Panikker P, Iqbal S, Elefant F.
  PLoS One;11(7):e0159623.

2015

• AMPK-HDAC5 Pathway Facilitates Nuclear Accumulation of HIF-1α and Functional Activation of HIF-1 by Deacetylating Hsp70 in the Cytosol.
  Chen S, Yin C, Lao T, Liang D, He D, Wang C, Sang N.
  Cell Cycle 14(15):2520-36.
• Axonal amphoterin mRNA is regulated by translational control and enhances axon outgrowth.
  Merianda TT, Coleman J, Kim HH, Kumar Sahoo P, Gomes C, Brito-Vargas P, Rauvala H, Blesch A, Yoo S, Twiss JL.
  J Neurosci. 35(14):5693-706.
• Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.
  Xu S., Elefant F.
  Fly (Austin) 9(1):22-8.
• Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon.
  Meibalan E, Comunale MA, Lopez AM, Bergman LW, Mehta A, Vaidya AN, Burns JM Jr.
  Eukaryot Cell 14(4):371-84.
• Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy.
  Orynbayeva Z, Sensenig R, Polyak B.
  Nanomedicine (Lond);10(10)1555-68.
• Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules. 
  Leo L, Yu W, D'Rozario M, Waddell EA, Marenda DR, Baird MA, Davidson MW, Zhou B, Wu B, Baker L, Sharp DJ, Baas PW.
  Cell Rep;12(11):1723-30.

2014

• Septins promote stress fiber-mediated maturation of focal adhesions and renal epithelial motility.
  Dolat L, Hunyara JL, Bowen JR, Karasmanis EP, Elgawly M, Galkin VE, Spiliotis ET.
  J Cell Biol. 207(2):225-35.
• Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action.
  Xu S, Wilf R, Menon T, Panikker P, Sarthi J, Elefant F.
  Genetics 198(4):1571-86.
• Cyclopamine Modulates Gamma-Secretase Mediated Cleavage of Amyloid Precursor Protein by Altering its Subcellular Trafficking and Lysosomal Degradation.
  Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Khandelwal PJ, Kim FJ, Marenda DR, Saunders AJ.
  J Biol Chem. 289(48):33258-74.
• Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.
  Mhatre SD, Michelson SJ, Gomes J, Tabb LP, Saunders AJ, Marenda DR.
  Exp Neurol. 261C:772-781.
• Synaptic abnormalities in a Drosophila model of Alzheimer's disease.
  Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR.
  Dis Model Mech. 7(3):373-85.
• Molecular determinants of the axonal mRNA transcriptome.
  Gomes C, Merianda TT, Lee SJ, Yoo S, Twiss JL.
  Dev Neurobiol. 74(3):218-32.
• Pathogenic mutation of spastin has gain-of-function effects on microtuble dynamics.
  Solowska JM, D'Rozario M, Jean DC, Davidson MW, Marenda DR, Baas PW.
  J Neurosci;34(5):1856-67.
• Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction.
  Ghosh R, Vegesna S, Safi R, Bao H, Zhang B, Marenda DR, Liebl FL.
  PLoS One;9(11):e113494.
• Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.
  Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y.
  Mol Cell;53(4):562-76.

2013

• Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules.
  Bai X, Bowen JR, Knox TK, Zhou K, Pendziwiat M, Kuhlenbäumer G, Sindelar CV, Spiliotis ET.
  J Cell Biol. 203(6):895-905.
• Angioneural crosstalk in scaffolds with oriented microchannels for regenerative spinal cord injury repair.
  Saglam A, Perets A, Canver AC, Li HL, Kollins K, Cohen G, Fischer I, Lazarovici P, Lelkes PI.
  J Mol Neurosci. 49(2):334-46.
• A HAT for sleep?: epigenetic regulation of sleep by Tip60 in Drosophila.
  Pirooznia SK, Elefant F.
  Fly (Austin). 7(2):99-104.
• Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.
  Johnson AA, Sarthi J, Pirooznia SK, Reube W, Elefant F.
  J Neurosci. 33(17):7535-47.
• Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements.
  Merianda TT, Gomes C, Yoo S, Vuppalanchi D, Twiss JL.
  J Neurosci. 33(34):13735-42.
• Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells.
  Jiang J, Fisher E, Murasko DM.
  Immun Ageing. 10(1):36.
• Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses.
  Jiang J, Fisher EM, Murasko DM.
  Exp Gerontol. 48(6):579-86.  
• A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element.
  Yoo S, Kim HH, Kim P, Donnelly CJ, Kalinski AL, Vuppalanchi D, Park M, Lee SJ, Merianda TT, Perrone-Bizzozero NI, Twiss JL.
  J Neurochem. 126(6):792-804.
• Axonally synthesized β-actin and GAP-43 proteins support distinct modes of axonal growth.
  Donnelly CJ, Park M, Spillane M, Yoo S, Pacheco A, Gomes C, Vuppalanchi D, McDonald M, Kim HH, Merianda TT, Gallo G, Twiss JL.
  J Neurosci. 33(8):3311-22.
• Axonal transport of neural membrane protein 35 mRNA increases axon growth.
  Merianda TT, Vuppalanchi D, Yoo S, Blesch A, Twiss JL.
  J Cell Sci. 126(Pt 1):90-102.

2012

• Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep.
  Pirooznia SK, Chiu K, Chan MT, Zimmerman JE, Elefant F.
  Genetics 192(4):1327-45.
• Drosophila lilliputian is required for proneural gene expression in retinal development.
  Distefano GM, Gangemi AJ, Khandelwal PJ, Saunders AJ, Marenda DR.
  Dev Dyn. 241(3):553-62.
• Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons.
  Hu J, Bai X, Bowen JR, Dolat L, Korobova F, Yu W, Baas PW, Svitkina T, Gallo G, Spiliotis ET.
  Curr Biol. 22(12):1109-15.
• Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.
  Spillane M, Ketschek A, Donnelly CJ, Pacheco A, Twiss JL, Gallo G.
  J Neurosci. 32(49):17671-89.
• Localized IRES-dependent translation of ER chaperone protein mRNA in sensory axons.
  Pacheco A, Twiss JL.
  PLoS One. 7(7):e40788.
• Subcellular knockout of importin β1 perturbs axonal retrograde signaling. 
  Perry RB, Doron-Mandel E, Iavnilovitch E, Rishal I, Dagan SY, Tsoory M, Coppola G, McDonald MK, Gomes C, Geschwind DH, Twiss JL, Yaron A, Fainzilber M.
  Neuron. 75(2):294-305.
• Differential effects of stimulatory factors on natural killer cell activities of young and aged mice.
  Nogusa S, Murasko DM, Gardner EM.
  J Gerontol A Biol Sci Med Sci. 67(9):947-54.  
• Lysophosphatidic acid differentially regulates axonal mRNA translation through 5’ UTR elements.
  Vuppalanchi D, Merianda TT, Donnelly C, Pacheco A, Williams G, Yoo S, Ratan RR, Willis DE, Twiss JL.
  Mol Cell Neurosci. 50(2):136-46.
• Two mutations impair the stability and function of ubiquitin-activating enzyme (E1).
  Lao T, Chen S, Sang N.
  J Cell Physiol. 227(4):1561-8.
• Axonal transcription factors signal retrogradely in lesioned peripheral nerve.
  Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, Yudin D, Rishal I, Rother F, Bader M, Blesch A, Pilpel Y, Twiss JL, Fainzilber M.
  EMBO J. 31(6):1350-63.

2011

• Axonal localization of transgene mRNA in mature PNS and CNS neurons.  
  Willis DE, Xu M, Donnelly CJ, Tep C, Kendall M, Erenstheyn M, English AW, Schanen NC, Kirn-Safran CB, Yoon SO, Bassell GJ, Twiss JL.
  J Neurosci. 31(41):14481-7.
• Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity.
  Donnelly CJ, Willis DE, Xu M, Tep C, Jiang C, Yoo S, Schanen NC, Kirn-Safran CB, van Minnen J, English A, Yoon SO, Bassell GJ, Twiss JL.
  EMBO J. 30(22):4665-77.
• Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia.
  Bowen JR, Hwang D, Bai X, Roy D, Spiliotis ET.
  J Cell Biol. 194(2):187-97.
• Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.
  He S, Kato K, Jiang J, Wahl DR, Mineishi S, Fisher EM, Murasko DM, Glick GD, Zhang Y.
  PLoS One. 6(5):e20107.
• Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.
  Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR.
  PLoS One. 6(6):e20799.
• Expansion of regulatory T cells in aged mice following influenza infection.
  Williams-Bey Y, Jiang J, Murasko DM.
  Mech Ageing Dev. 132(4):163-70.
• Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism.
  Lorbeck MT, Pirooznia K, Sarthi J, Elefant F.
  PLoS One. 6(4):e18412.
• Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
  Curtis BJ, Zraly CB, Marenda DR, Dingwall AK.
  Dev Biol. 350(2):534-47.
• Tip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction.
  Sarthi J, Elefant F.
  PLoS One. 6(10):e26202.

2010

• Kismet/CHD7 regulates axon morphology, memory and locomotion in a Drosophila model of CHARGE syndrome.
  Melicharek DJ, Ramirez LC, Singh S, Thompson R, Marenda DR.
  Hum Mol Genet. 19(21):4253-64. 
• The histone acetyltransferase Elp3 plays an active role in the control of synaptic bouton expansion and sleep in Drosophila.
  Singh N, Lorbeck MT, Zervos A, Zimmerman J, Elefant F. 
  J Neurochem. 115(2):493-504.
• Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells.
  Jiang J, Fisher E, Bennett AJ, Murasko DM.
  Mech Ageing Dev. 131(9):580-3.
• MAP Kinase phosphorylation is dispensable for cell division, but required for cell growth in Drosophila.
  Majumdar N, Paez GL, Inamdar SM, D'Rozario M, Marenda DR.
  Fly (Austin). 4(3).