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Myungwoon Lee

Myungwoon Lee, PhD

Assistant Professor
Department of Chemistry

Education:

  • Postdoctoral fellow, National Institutes of Health, 2022
  • PhD, Physical Chemistry, Massachusetts Institute of Technology, 2018
  • BS, Physics, University of Seoul, 2006

Curriculum Vitae:

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Research Interests:

  • Neurodegenerative protein aggregation
  • Membrane associated amyloid fibrils
  • Molecular structures, dynamics, and intermolecular interactions of biological macro molecules
  • Solid-state NMR and Cryo-electron microscopy (Cryo-EM)

Bio:

Myungwoon Lee received her BS in Physics at University of Seoul (Korea). After working at Samsung Electronics (Korea) as a senior research engineer, she started her graduate research and received her PhD in Physical Chemistry at MIT. After her postdoctoral research at NIH, she joined the faculty at Drexel University as an assistant professor in January 2023.

Selected Publications:

Amyloid fibrils

  • M. Lee, U. Ghosh, K.R. Thurber, M. Kato, R. Tycko, “Molecular Structure and Interactions within Amyloid-Like Fibrils Formed by a Low Complexity Protein Sequence from FUS”, Nat. Commun. 11, 5735 (2020). https://doi.org/10.1038/s41467-020-19512-3  
  • M. Lee, T. Wang, O.V. Makhlynets, Y. Wu, N.P. Polizzi, H. Wu, P.M. Gosavi, J. Stöhr, I.V. Korendovych, W.F. DeGrado, M. Hong, “Zinc-Binding Structure of a Catalytic Amyolid from Solid-State NMR”, Proc. Natl. Acad. Sci. USA 114 (24), 6191-6196 (2017). https://doi.org/10.1073/pnas.1706179114  

Viral fusion proteins 

  • M. Lee, C.M. Morgan, M. Hong, “Fully Hydrophobic HIV gp41 Adopts a Hemifusion-like Conformation in Phospholipid Bilayers”, J. Biol. .Chem. 294, 14732-14744 (2019). https://doi.org/10.1074/jbc.RA119.009542
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  • M. Lee, B. Kwon, A. Waring, M. Hong, “Oligomeric Structure and Three-dimensional Fold of the HIV gp41 MPER and Transmembrane Domain in Phospholipid Bilayers”, J. Am. Chem. Soc. 140 (26), 8246-8259 (2018). https://doi.org/10.1021/jacs.8b04010