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Fraser Fleming, PhD

Fraser Fleming, PhD

Department of Chemistry
Office: Stratton 410
Phone: 215.895.2644

Additional Sites:

Fleming Group


  • Oregon State University, Post-doctoral fellow, 1990-1992
  • University of British Columbia (Canada) PhD Organic Chemistry, 1990
  • Massey University (New Zealand), BS (Hons.) Chemistry, 1986

Curriculum Vitae:

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Research Interests:

  • Rapidly constructing biologically relevant scaffolds as potential pharmaceutical leads
  • Metalated nitriles as potent nucleophiles for hindered bond construction
  • Metalated isocyanides as precursors to peptide mimics


Fraser Fleming earned his BS (Hons.) at Massey University, New Zealand, in 1986 and a PhD under the direction of Edward Piers at the University of British Columbia, Canada, in 1990. After postdoctoral research with James D. White at Oregon State University he joined the faculty at Duquesne University, Pittsburgh, in 1992. In 2013 he took a temporary position as a program director at the National Science Foundation working in the Synthesis Program and the Catalysis Program. His research interests lie in stereochemistry and organometallics, particularly as applied to the reactions of nitriles and isonitriles.

Selected Publications:

  1. "Multiple Isocyanide insertions promoted by protic and Lewis acids" Kornfeind, J.; Fleming, F. F. Tetrahedron Chem 2024, 9, 100056.
  2. "Heterocycles via SiCl4-Promoted Isocyanide Additions to Oxonitriles" Kornfeind, J.; Allen, J. E.; Keller, T. M.; Fleming, F. F. J. Org. Chem. 2023, 88, 15947−15955.
  3. "Polar-Radical Cyclization Cascades with Magnesiated Nitriles" Bolgunas, S.; Paleo, E.; Alwedi, E.; Wei, Y.; Keller, T. M.; Fleming, F. F. Org. Lett. 2023, 25, 3512−3516.
  4. "One-Pot Syntheses of Substituted Oxazoles and Imidazoles from the Isocyanide Asmic" Mueller, L. G. Jr.; Keller, T. M.; Fleming, F. F. J. Org. Chem. 2023, 19, 909-916.
  5. "Stereoselective Synthesis of E- and Z-Isocyanoalkenes" Tian, H.; Holyoke, C. W. Jr.; Fleming, F. F. Org. Lett. 2022, 24, 8657–8661.
  6. "Dearomatization of Aromatic Asmic Isocyanides to Complex Cyclohexadienes" Altundas, B.; Alwedi, E.; Song, Z.; Gogoi, A. R.; Dykstra, R.; Gutierrez, O.; Fleming, F. F. Nat. Commun. 2022, 13, 6444.
  7. "Oxidative DMSO Cyclization Cascade to Bicyclic Hydroxyketonitriles" Kornfeind, J.; Iyer, P.; Keller, T. M.; Fleming, F. F. J. Org. Chem. 2022, 87, 6097–6104.
  8. "Copper-Catalyzed Conjugate Additions to Alkeneisocyanides" Marrazzo, J.-P. R.; Chao, A.; Li, Y.; Fleming, F. F. J. Org. Chem. 2022, 87, 488−497.
  9. "One-step Synthesis of Imidazoles from Asmic Isocyanide and Nitriles" Mueller, L. G.; Chao, A.; AlWedi, E.; Fleming, F. F. Beilstein J. Org. Chem. 2021, 17, 1499-1502.
  10. "Synthesis of the Isocyanide Building Block Asmic, anisylsulfanylmethylisocyanide" Alwedi, E.; Altundas, B.; Chao, A.; Ziminsky, Z. L.; Natrayan, M.; Fleming, F. F. Org. Synth. 2021, 98, 147-170. DOI: 10.15227/orgsyn.098.0147

Academic Details:

Graduate Program Faculty Member

*Only Graduate Program Faculty members can mentor graduate students