Neighborhood Impacts of Cognitive Health and Dementia Disparities
Understanding the impacts of neighborhood factors for cognitive health and dementia disparities within a Multi-Ethnic Cohort
Summary
This project leverages and extends novel longitudinal neighborhood and cognition data from the Multi-Ethnic Study of Atherosclerosis (MESA). It addresses major research gaps by identifying unique patterns of neighborhood change related to the causes of prevalence and disparities in cognitive decline and dementia. This work facilitates actionable community and clinical interventions to address and remediate racial and socioeconomic inequalities derived from the unequal distribution of environmental supports for healthy aging.
Partners
Multi Ethnic Study of Atherosclerosis Coordinating Center at University of Washington; MESA field centers; MESA MIND Ancillary Study.
Research Methods
This project will undertake large-scale collection, processing, and distribution of new neighborhood data within MESA. The main objective is to identify unique patterns of neighborhood change related to the causes of prevalence and disparities in cognitive decline and dementia. The main objective will be attained by (Aim 1) characterizing dynamic, longitudinal neighborhood social and built environment variables (survey-based and GIS-derived) relevant to cognition for residential addresses of a MESA; (Aim 2) examining associations of neighborhood environmental characteristics with cognition and clinically relevant ADRD outcomes; (Aim 3) investigate determinants of disparities in ADRD outcomes by socioeconomic position and race/ethnicity and assess the contribution of neighborhood environments.
Research Results
Hirsch JA, Michael YL, Moore KA, Melly S, Hughes TM, Hayden K, Luchsinger JA, Jimenez MP, James P, Besser LM, Sánchez B, Diez Roux AV. Longitudinal neighbourhood determinants with cognitive health and dementia disparities: protocol of the Multi-Ethnic Study of Atherosclerosis Neighborhoods and Aging prospective cohort study. BMJ Open. 2022 Nov 11;12(11):e066971. doi: 10.1136/bmjopen-2022-066971. PMID: 36368762; PMCID: PMC9660618.
Hirsch, J.A., Moore, K.A., Cahill, J., Quinn, J., Zhao, Y., Bayer, F.J., Rundle, A. and Lovasi, G.S., 2020. Business Data Categorization and Refinement for Application in Longitudinal Neighborhood Health Research: a Methodology. Journal of Urban Health, Oct 1, pp.1-14.
Besser, L., Chang, L. C., Evenson, K. R., Hirsch, J., Michael, Y., Galvin, J. E., ... & Hughes, T. M. (2021). Associations between neighborhood park access and longitudinal change in cognition in older adults: The multi-ethnic study of atherosclerosis. Journal of Alzheimer's Disease, (Preprint), 1-13.
Besser, L. M., Chang, L. C., Hirsch, J. A., Rodriguez, D. A., Renne, J., Rapp, S. R., ... & Hughes, T. M. (2021). Longitudinal Associations between the Neighborhood Built Environment and Cognition in US Older Adults: The Multi-Ethnic Study of Atherosclerosis. International Journal of Environmental Research and Public Health, 18(15), 7973.
Acknowledgements
Research Team:
- Jana A. Hirsch, PhD, MES, Associate Research Professor, Urban Health Collaborative
- Yvonne Michael, ScD, SM, Associate Professor, Dornsife School of Public Health
- Brisa Sanchez, PhD, Dornsife Endowed Professor of Biostatistics, Dornsife School of Public Health
- Ana Diez Roux, MD, PhD, MPH, Distinguished University Professor of Epidemiology, Dornsife School of Public Health; Director, Urban Health Collaborative
- Kari Moore, MS, Research and Data Core Co-lead, Urban Health Collaborative
- Steve Melly, MS, MA, Geographic Information System (GIS) Specialist, Urban Health Collaborative
- Lilah M. Besser, PhD, MSPH, University of Miami
- Tara McAlexander, PhD, MPH, Assistant Research Professor, Dornsife School of Public Health
- Jingjing Li, PhD, Associate Professor, China University of Geosciences
- Amy Auchincloss, PhD, MPH, Associate Professor, Dornsife School of Public Health
- Cassie Bambrick, MPH, Urban Health Collaborative
- Marcia Pescador Jimenez, PhD, MS, Boston University
- Channa Buxbaum, Research Fellow, Dornsife School of Public Health
- Sandi Shrager, Multi Ethnic Study of Atherosclerosis Coordinating Center at University of Washington
- Alison Long, Research Assistant, Dornsife School of Public Health
- Steven Shea, MD, MESA field centers
- Alain Bertoni, MD, MESA field centers
- James Pankow, PhD, MPH, MESA field centers
- Norrina Allen, PhD, MESA field centers
- Teresa Seeman, PhD, MESA field centers
- Wendy Post, MD, MS, MESA field centers
- Timothy Hughes, PhD, MESA MIND Ancillary Study
- Kathleen Hayden, PhD, MESA MIND Ancillary Study
- Jose Luchsinger, MD, MESA MIND Ancillary Study
Partners:
Funding provided by the National Institutes of Health National Institute on Aging.