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Jun Xi

Jun Xi, PhD

Associate Teaching Professor
Department of Chemistry
Office: Disque Hall 218
Phone: 215.895.2648
Fax: 215.895.2655


  • PhD, Cornell University, 2002
  • MS, Bioorganic Chemistry, Tufts University, 1991
  • BS, Organic Chemistry, Beijing University, 1988

Curriculum Vitae:

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Research Interests:

  • QCM
  • Cell adhesion
  • Enzyme
  • Problem-based learning
  • Peer learning


Dr. Jun Xi is an associate teaching professor of the Department of Chemistry at Drexel University. He obtained his PhD degree in organic chemistry from Cornell University with his research being focused on probing the mechanism of Thiamin biosynthesis with bioorganic chemistry approaches. He received his postdoctoral training in mechanistic enzymology at The Penn State University, where he developed a single molecule technique to investigate the assembly of DNA replisome. He worked briefly as a senior research scientist in Department of Biochemical Technologies in Corning Inc., where his main responsibility was to develop a unique cell-based assay with the use of optical waveguide sensor technology for drug screening. Since he came to Drexel University, Dr. Jun Xi and his group have been focusing on applying nanomechanical sensor technologies to investigate interfacial properties of biological systems related to issues in both human health and alternative sources of energy. He has published numerous research papers, book chapters, and patents and received numerous financial supports. His group has expertise in a variety of research fields including chemistry, biochemistry, and cell biology.

Dr. Jun Xi is committed to helping students achieve their goals and benefiting them in their future careers. To accomplish this mission, he wants to create for students an atmosphere, both in the classroom and in the laboratory, where they can share his knowledge and enthusiasm for chemistry and be intellectually challenged. Such an atmosphere will foster students’ mastery of conceptual material and related basic skills and, more importantly, will allow them to develop broader and more useful skills such as communication, critical thinking, and problem solving, through self-directed learning and team work. Dr. Jun Xi’s primary responsibilities are to teach undergraduate students organic chemistry, both lecture and laboratory courses.

Selected Publications:

  • Chen JY, Pan Y, Collins TJ, Penn LS, Xi N, Xi J (2019) Examining the Feasibility of A “Top-Down” Approach to Enhancing the Keratinocyte-Implant Adhesion. Experimental Cell Research 376(2), 105-113. [DOI:]
  • On the Measurement of Energy Dissipation of Adhered Cells with the Quartz Microbalance with Dissipation Monitoring. Monemian EA., Zhao W, Chen JY, Huang C, Xi N, Xi J, Yang R (2018) Analytical Chemistry 90(17), 10340-10349. [DOI: 10.1021/acs.analchem.8b02153]
  • Chen JY, Penn LS & Xi J (2018) Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond. Biosensors and Bioelectronics 99, 593-602. [doi:]
  • Chen JY, Shahid A, Garcia MP, Penn LS & Xi J. (2012) Dissipation monitoring for assessing EGF-induced changes of cell adhesion. Biosensors and Bioelectronics 38(1), 375-381. [DOI: 10.1016/j.bios.2012.06.018]
  • Chen JY, Li M, Penn LS & Xi J. (2011) Real-time and label-free detection of cellular response to signaling mediated by distinct subclasses of epidermal growth factor receptors. Analytical Chemistry 83, 3141-3146. [DOI: 10.1021/ac200160u]
  • Zhao L, Bulhassan A, Yang G, Ji H & Xi J. (2010) Real-time detection of the morphological change in cellulose by a nanomechanical sensor. Biotechnology and Bioengineering 107, 190-194. [DOI: 10.1002/bit.22754]
  • i J, Zhang Z, Zhuang Z, Yang J, Spiering MM, Hammes GG & Benkovic SJ. (2005) Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): Unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Biochemistry 44, 7747-56. [DOI: 10.1021/bi047296w]
  • Zhang Z, Spiering MM, Trakselis MA, Ishmael FT, Xi J, Benkovic SJ & Hammes GG. (2005) Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proc Natl Acad Sci U S A. 102:3254-3259. [DOI: 10.1073/pnas.0500327102]
  • Xi J, Ge Y, Maclafferty F & Begley TP. (2001) Thiamin biosynthesis in Escherichia coli: identification of a ThiF-ThiS thiocarboxylate protein-protein conjugate as the intermediate to thiazole formation. Proc Natl Acad Sci U S A. 98:8513-8. [DOI: 10.1073/pnas.141226698]
  • Wang C, Xi J, Begley TP & Nicholson LK. (2001) Solution structure of ThiS and implications for the evolutionary roots of ubiquitin. Nat Struct Biol. 8:47-51. [DOI: 10.1038/83041]