Catherine von Reyn, PhD
School of Biomedical Engineering, Science & Health Systems
Office: Bossone 707
Neural Circuit Engineering (NCE) Laboratory
PhD, Bioengineering, University of Pennsylvania, 2010
BS, Mechanical Engineering, Georgia Institute of Technology, 2003
Cell type-specific genetic engineering, whole-cell patch clamp in behaving animals, modeling, and detailed behavioral analysis to identify and characterize sensorimotor circuits.
Catherine von Reyn, PhD, received her BS in Mechanical Engineering from the Georgia Institute of Technology ('Georgia Tech') and her PhD in Bioengineering from the University of Pennsylvania. She was a postdoctoral associate in Gwyneth Card’s laboratory at the Janelia Research Campus of the Howard Hughes Medical Institute (HHMI) and is currently an assistant professor in the School of Biomedical Engineering, Science and Health Systems at Drexel University.
Dr. von Reyn's research uses diverse, cutting edge techniques, including cell type-specific genetic engineering, whole-cell patch clamp in behaving animals, modeling, and detailed behavioral analysis to identify and characterize sensorimotor circuits. She applies these techniques to engineer de novo synaptic connections in sensorimotor circuits with the long-term goal of developing genetic strategies for re-engineering circuits in neurodegenerative and neurophysiological disorders.
von Reyn CR, Breads P, Peek MY, Zheng GZ, Williamson WR, Yee AL, Leonardo A, Card GM. A Spike-timing Mechanism for Action Selection. Nature Neuroscience 06/2014; 17(7).
Schoch KM, von Reyn CR, Bian J, Telling GC, Meaney DF, Saatman KE. Brain Injury-induced Proteolysis is Reduced in a Novel Calpastatin-overexpressing Transgenic Mouse. Journal of Neurochemistry 01/2013; 125(6).
Mesfin MN, von Reyn CR, Mott RE, Putt ME, Meaney DF. In Vitro Stretch Injury Induces Time- and Severity-Dependent Alterations of STEP Phosphorylation and Proteolysis in Neurons. Journal of Neurotrauma 03/2012; 29(10):1982-98.
von Reyn CR, Mott RE, Siman R, Smith DH, Meaney DF. Mechanisms of Calpain Mediated Proteolysis of Voltage-gated Sodium Channel Alpha-subunits Following In Vitro Dynamic Stretch Injury. Journal of Neurochemistry 03/2012; 121(5):793-805.
von Reyn CR, Spaethling JM, Mesfin MN, Ma M, Neumar RW, Smith DH, Siman R, Meaney DF. Calpain Mediates Proteolysis of the Voltage-gated Sodium Channel Subunit. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 09/2009; 29(33):10350-6.
Spaethling JM, Geddes-Klein DM, Miller WJ, von Reyn CR, Singh P, Mesfin M, Bernstein SJ, Meaney DF. Linking Impact to Cellular and Molecular Sequelae of CNS Injury: Modeling In Vivo Complexity with In Vitro Simplicity. Progress in brain research 02/2007; 161:27-39.