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The Gao Lab Publications

"Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3b"
Xing B, Han G, Wang MJ, Snyder MA, Gao WJ
Neuropharmacology, 137:359-371 (2018)

"Cell-type specific development of the hyperpolarization-activated current, Ih, in prefrontal cortical neurons"
Yang SS, Li YC, Coley AA, Chamberlin LA, Yu P*, Gao WJ*
Frontiers in Synaptic Neuroscience 10(7):1-12 (2018)

"PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders"
Ferguson BR and Gao WJ*
Frontiers in Neural Circuits. 12:37 (2018)

"Lithium Inhibits GSK3β and Augments GluN2A Receptor Expression in the Prefrontal Cortex"
Monaco SA, Ferguson BR, and Gao WJ*
Front Cell Neurosci, 12:16 (2018)

"Thalamic control of cognition and social behavior via regulation of GABAergic signaling and E/I balance in the medial prefrontal cortex"
Ferguson BR and Gao WJ*
Biological Psychiatry 83:665-679 (2018)
Commentary: "Medial Prefrontal Cortex Excitation/Inhibition Balance and Schizophrenia-like Behaviors Regulated by Thalamic Inputs to Interneurons" (Drexel ID required to access)
Fan Z and Hu H
Biological Psychiatry, Volume 83, Issue 8, Pages 630-631 (April 15, 2018)

"PSD95: A synaptic protein implicated in schizophrenia or autism?"
Coley AA and Gao WJ*
Prog Neuropsychopharmacol Biol Psychiatry. 82:187-194. 2017, Nov 21. pii: S0278-5846(17)30658-9. doi: 10.1016/j.pnpbp.2017.11.016. [Epub ahead of print] Review. (2018)

"Psychostimulants As Cognitive Enhancers in Adolescents: More Risk than Reward?"
Urban KR and Gao WJ*
Front Public Health, 5:260. Sep 26;5:260. doi: 10.3389/fpubh.2017.00260. eCollection 2017. (2017)

"Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia"
Gulchina Y, Xu SJ, Snyder MA, Elefant F, Gao WJ*
J of Neurochemistry, 143(3):320-333. 2017 Jun 19. doi: 10.1111/jnc.14101 (2017)
The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex: An Editorial Highlight for 'Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia' on page 320. (Drexel ID required to access)
Zhu X, Gomes FV, Grace AA
J Neurochem. 2017 Nov;143(3):264-267. doi: 10.1111/jnc.14133. Epub 2017 Sep 5. PMID: 28872674

"A Clinically-Relevant Dose of Methylphenidate Enhances Synaptic Inhibition in the Juvenile Rat Prefrontal Cortex"
Urban K, Li YC, Xing B, Gao WJ
Journal of Reward Deficiency Syndrome & Addiction Science, in press (2017)

"Juvenile Treatment with a Novel mGluR2 Agonist/mGluR3 Antagonist Compound, LY395756, Reverses Learning Deficits and Cognitive Flexibility Impairments in Adults in A Neurodevelopmental Model of Schizophrenia"
Li ML, Gulchina Y, Monaco SA, Xing B, Ferguson BR, Li YC, Li F, Hu XQ, Gao WJ
Neurobiology of Learning and Memory, 140:52-61 (2017)

"GSK3β hyperactivity during an early critical period impairs prefrontal synaptic plasticity and induces lasting deficits in spine morphology and working memory"
Xing B, Li YC and Gao WJ
Neuropsychopharmacology, 41(13) (2016)

"Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex" [PDF]
Li YC, Yang SS and Gao WJ
Neuropharmacology, 108:403-414 (2016)

"Norepinephrine versus Dopamine and their Interaction in Modulating Synaptic Function in the Prefrontal Cortex" [PDF]
Xing B, Li YC and Gao WJ
Brain Research 1641 (Pt B):217-233 (invited review, 2016)

"LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment" [PDF]
Meng-Lin (Merry) Li, Shasha Yang, Xing B, Brielle Ferguson, Gulchina Y, Li YC, Feng Li*, Xi-Quan Hu* and Gao WJ*
Experimental Neurology 273:190-201 (2015)

"NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders" [PDF]
Monaco SA#, Gulchina Y# and Gao WJ (# These authors contribute equally)
Neuroscience and Biobehavioral Reviews 56:127-138 (2015)

"Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?" [PDF]
Meng-Lin (Merry) Li, Xi-Quan Hu, Feng Li and Gao WJ
Progress in Neuropsychopharmacology & Biological Psychiatry 60:66-76 (review, 2015)

"Development of thalamocortical connections between the mediodorsal nucleus of the thalamus and the prefrontal cortex and its implication in executive and cognitive function" [PDF]
Ferguson BR and Gao WJ
Frontiers in Human Neuroscience, 8(1027):1-10 (invited review, 2015)

"Heterogeneous Organization of the Locus Coeruleus Projections to Prefrontal and Motor Cortices" [PDF]
Daniel J. Chandler, Gao WJ and Barry D. Waterhouse
PNAS, 111(18):6816-6821 (2014)

"New Perspectives on Catecholaminergic Regulation of Executive Circuits: Evidence for Independent Modulation of Prefrontal Functions by Midbrain Dopaminergic and Noradrenergic Neurons" [PDF]
Daniel J. Chandler, Barry D. Waterhouse and Gao WJ
Frontiers in Neural Circuits, 8:53 (invited review, May 23, 2014)

"Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain" [PDF]
Urban KR and Gao WJ
Frontiers in Systems Neuroscience, 8:38 (invited review, May 13, 2014)
Related Media:

"Impact of neuronal ferritin heavy chain in HIV/drug abuse patients" [PDF]
Jonathan Pitcher1,2*, Anna Abt1*, Jaclyn Myers1**, Rachel Han1, Melissa Snyder3, Alessandro Graziano1, Michele Kutzler4,2, Fernando Garcia5, Gao WJ3, Tracy Fisher-Smith6, Jay Rappaport6 and Olimpia Meucci1,2***
Journal of Clinical Investigation, 124(2)656-668 (2014)

"Methylphenidate and the juvenile brain: enhancement of attention at the expense of cortical plasticity?" [PDF]
Urban KR and Gao WJ
Medical Hypotheses, 81:988-994 (2013)

"Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in prefrontal cortical microcircuitry" [PDF}
Huai-Xing Wang, Barry Waterhouse and Gao WJ
Neuroscience, 246:312-328 (2013)

"Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons" [PDF]
Wang MJ, Li YC, Melissa A. Snyder, Huai-Xing Wang, Feng Li* and Gao WJ*
PLOS ONE 8(4):e61787 (2013)

"NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia" [PDF]
Melissa A. Snyder and Gao WJ
Frontiers in Cellular Neuroscience, 7:31 (invited review, 2013)

"Treatment with a clinically-relevant dose of methylphenidate alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex" [PDF]
Urban KR, Li YC and Gao WJ
Neurobiology of Learning and Memory, 101:65-74 (2013)

"Gestational methylazoxymethanol (MAM) exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning" [PDF]
Melissa A. Snyder, Alicia E. Adelman and Gao WJ
Neuropsychopharmacology, 38:328-340 (2013)

"Evolution of the Study of Methylphenidate and its Actions on the Adult versus Juvenile Brain"
Urban KR and Gao WJ
Journal of Attention Disorders, 101:65-74 [Epub ahead of print] (Aug. 24, 2013)

"Hyperdopaminergic Modulation of Inhibitory Transmission Is Dependent on GSK-3β Signaling-Mediated Trafficking of GABAa Receptors" [PDF]
Li YC, Wang MJ and Gao WJ
Joural of Neurochemistry, 122:308-320 (2012)

"Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons" [PDF]
Kimberly Urban, Barry Waterhouse and Gao WJ
Biological Psychiatry, 72(10):880-888 (2012)

"Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex" [PDF]
Huai-Xing Wang and Gao WJ
Neuropharmacology, 62:1808-1822 (2012)

"D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in prefrontal cortex" [PDF]
Li YC, Christoph Kellendonk , Eleanor H. Simpson, Eric R. Kandel and Gao WJ
PNAS, 108(29):12107-112 (2011) - Commentary in Schizophrenia Research Forum [schizophreniaforum.org/new/detail.asp?id=1680]

"Experimental strategies for investigating drug actions in ADHD and related attention disorders" [PDF]
Agster K, Clark B, Gao WJ, Shumsky J, Wang HX, Berridge C and Waterhouse B
Anatomical Record, 294:1698-1712 (invited review, 2011)

"Group II metabotropic glutamate receptor agonist ameliorates MK-801-induced dysfunction of NMDA receptors via Akt/GSK-3b pathway" [PDF]
Dong Xi*, Li YC*, Melissa A. Snyder*, Ruby Y. Gao, Alicia E. Adelman, Wentong Zhang, Jed S. Shumsky and Gao WJ (* these authors contribute equally)
Neuropsychopharmacology, 36:1260-1274 (2011)

"GSK-3Β and hyperdopaminergic behaviors" [PDF]
Li YC and Gao WJ
Neuroscience & Biobehavioral Reviews, 35:645-654 (2011)

"Development of calcium-permeable AMPA receptors and their correlation with NMDA receptors in fast-spiking interneurons of rat prefrontal cortex" [PDF]
Huai-Xing Wang and Gao WJ
The Journal of Physiology, 588(15):2823-2838 (2010) [selected for Faculty of 1000 Medicine (www.f1000medicine.com) and evaluated by Dr. Antonio Pisani, f1000medicine.com/article/wrlpf8s7ydqdhqh/id/5451956.

"Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons" [PDF] Jian-Li Hu *, Gang Liu *, Li YC *, Gao WJ and Yue-Qiao Huang (* these authors contribute equally)
Molecular Brain, 3:20 (2010)

"Dopamine D1 receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons" [PDF]
Li YC 1, Gang Liu 1, Jian-Li Hu 1, Gao WJ* and Yue-Qiao Huang* (1 these authors contribute equally)
The Journal of Neurochemistry, 114:62-73 (2010)

"Activation of GSK-3Β is required for hyperdopamine and D2 receptor mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex" [PDF]
Li YC, Dong Xi, Joy Roman, Yue-Qiao Huang and Gao WJ
Journal of Neuroscience, 29(49):15551-15563 (2009)

"Role of dysbindin in dopamine receptor trafficking and cortical GABA function" [PDF]
Ji Y, Yang F, Papaleo F, Wang HX, Gao WJ, Weinberger DR and Lu B
PNAS, 106:19593-19598 (2009)

"Dizocilpine (MK-801) induces distinct changes of N-methyl-d-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex" [PDF]
Xi D, Zhang W, Wang HX, Stradtman GG III and Gao WJ
Int J Neuropsychopharmacol, 12:1395-1408 (2009)

"Cell-type specific development of NMDA receptors in the interneurons of rat prefrontal cortex" [PDF]
Wang HX and Gao WJ
Neuropsychopharmacology, 34(8):2028-2040 (2009)

"NMDA receptor subunit expression in GABAergic interneurons in the prefrontal cortex: application of laser microdissection technique" [PDF]
Xi D, Keeler B, Zhang W, Houle JD and Gao WJ
Journal of Neuroscience Method, 176:172-181 (2009)

"A specialized NMDA receptor function in the recurrent microcircuitry of the adult prefrontal cortex" [PDF]
Wang HX, Stradtman GG III, Wang X-J and Gao WJ
PNAS, 105(43):16791-16796 (2008)

"Acute clozapine suppresses synchronized pyramidal synaptic network activity by increasing inhibition in the prefrontal cortex"
Gao WJ
The Journal of Neurophysiology, 97:1196-1208 (2007)

"NMDA receptor-mediated epileptiform persistent activity requires calcium release from internal stores" [PDF]
Gao WJ and Goldman-Rakic PS
Experimental Neurology, 197:495-504 (2006)

"Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex" [PDF]
Gao WJ and Zheng ZH
The Journal of Comparative Neurology, 476:174-185 (2004)

"Selective Modulation of Excitatory and Inhibitory Microcircuits by Dopamine" [PDF]
Gao WJ and Goldman-Rakic PS
PNAS, 100(5):2836-41 (2003)

"Dopamine modulation of peridendritic and perisomatic inhibition in prefrontal cortex" [PDF]
Gao WJ, Wang Y and Goldman-Rakic PS
The Journal of Neuroscience, 23:1622-30 (2003)

"Presynaptic regulation of recurrent excitation by D1 receptor in prefrontal circuits" [PDF]
Gao WJ, Krimer LS and Goldman-Rakic PS
PNAS, 98:295-300 (2001)

"Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: immunocytochemical localization of parvalbumin and calbindin-containing neurons"
Gao WJ, Wormington AB, Newman DE and Pallas SL
The Journal of Comparative Neurology, 422:140-157 (2000)

"Cross-modal reorganization of horizontal connectivity in auditory cortex without altering thalamocortical input"
Gao WJ and Pallas SL
The Journal of Neuroscience, 19(18):7940-7950 (1999)

"Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: immunocytochemical localization of GABAergic neurons"
Gao WJ, Newman DE, Wormington AB and Pallas SL
The Journal of Comparative Neurology, 409(2):261-273 (1999)

 
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Recent Review and Book Chapters

"NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders"
Monaco SA#, Gulchina Y# and Gao WJ (# these authors contributed equally)
Neuroscience and Biobehavioral Reviews, 56:127-138 (accepted, 2015)

"Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?"
Li ML, Xi-Quan Hu, Feng Li, Gao WJ
Progress in Neuropsychopharmacology & Biological Psychiatry, 60:66-76 (review, 2015)

"Development of thalamocortical connections between the mediodorsal nucleus of the thalamus and the prefrontal cortex and its implication in executive and cognitive function"
Ferguson BR and Gao WJ
Frontiers in Human Neuroscience, 8(1027):1-10 (invited review, 2015)

"New Perspectives on Catecholaminergic Regulation of Executive Circuits: Evidence for Independent Modulation of Prefrontal Functions by Midbrain Dopaminergic and Noradrenergic Neurons"
Daniel J. Chandler, Barry D. Waterhouse and Gao WJ
Frontiers in Neural Circuits, May 23, 8:53 (invited review, 2014)

"Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain"
Urban KR and Gao WJ
Frontiers in Systems Neuroscience, May 13, featured article (invited review, 2014)

"NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia" Melissa A. Snyder and Gao WJ
Frontiers in Cellular Neuroscience, 7:31 (invited review, 2013)

"Evolution of the Study of Methylphenidate and its Actions on the Adult versus Juvenile Brain"
Urban KR and Gao WJ
Journal of Attention Disorders (in press, 2012)

"GSK-3 and hyperdopaminergic behaviors"
Li YC and Gao WJ
Neuroscience & Biobehavioral Reviews, 35:645-654 (2011)

"Experimental strategies for investigating drug actions in ADHD and related attention disorders"
Agster K, Clark B, Gao WJ, Shumsky J, Wang HX, Berridge C and Waterhouse B
Anatomical Record, 294:1698-1712 (invited review, 2011)

"Dopaminergic and Glutamatergic Dysfunctions in the Neuropathophysiology of Schizophrenia"
Gao WJ

In: “Dopamine: Functions, Regulation and Health Effects”, edited by Endo Kudo and Yuriko Fujii. Nova Publishers (2011)

"The unique properties of the prefrontal cortex and mental illness"
Gao WJ, Huai-Xing Wang, Melissa A. Snyder and Li YC
In: “When Things Go Wrong – Diseases and Disorders of the Human Brain”, edited by Theo Mantamadiotis, Intech Publisher (2012)

 
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Synaptic connections between pyramidal neurons and GABAergic interneurons. The neurons were labeled with bicytin during patch clamp recording and reconstructed with Neurolucida system.