Drs. Peter Lewin, Richard B. Beard Distinguished University Professor and Director, Biomedical Ultrasound Research and Education Center (PI), Leonid Zubkov, and Michael Neidrauer (all in BIOMED), along with Drs. Michael Weingarten (CoM), Rose DiMaria-Ghalili (CNHP), and David Margolis (UPenn), received a 5-year $3M NIH R01 grant for the project titled, "Enhanced Ultrasound Treatment of Chronic Wounds with Monitoring of Healing and Quality of Life Outcomes.” The goal of this project – through an interdisciplinary approach in close collaboration amongst the School of Biomedical Engineering, Science and Health Systems, the College of Medicine, and the College of Nursing and Health Professions – is to develop a novel and unique combination of a lightweight, battery-powered low frequency ultrasound applicator for chronic wound therapy with noninvasive optical wound diagnostics, and detailed analysis of the nutritional and inflammatory status of patients who respond to the treatment. The study, which is the first of its kind, will evaluate the effect of the ultrasound treatment on wound healing and health-related quality of life with a randomized clinical trial of 60 patients with venous ulcers and 60 patients with diabetic ulcers.