Human Disease, Long Noncoding RNA, and Animal Models
Tuesday, January 12, 2016
12:00 PM-2:00 PM
BIOMED PhD Research Proposal
Title: Human Disease, Long Noncoding RNA, and Animal Models
Speaker: Debra Klopfenstein, PhD candidate, School of Biomedical Engineering, Science and Health Systems
Advisor: Aydin Tozeren, PhD, Professor, School of Biomedical Engineering, Science and Health Systems
Abstract:It has been found that genes associated with disease do not distribute uniformly across the topology of the human genome, but instead frequently form clusters of disease. This research proposal focuses on the spatial topology of disease-linked genes in the human genome. Specifically, we discover and functionally annotate the clusters formed by genes linked to one or more of the 40 disease subtypes. In addition to protein coding genes, we focus on long noncoding RNA genes as they play important roles in gene regulation. Finally, we look at animal models: specifically the mouse and fruit fly, to identify regions relevant to disease in the human.
Contact Information
Ken Barbee
215-895-1335
barbee@drexel.edu