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Ion channels are proteinaceous pores expressed in all living cells, facilitating charged ions, small organic and inorganic molecules to pass through lipid bilayers towards equilibrium. They participate in gene transcription, cell signaling, electrical excitability, neurotransmitter release, muscle contraction, cell secretion, enzyme activation and signal transduction.

In addition to the plasma membrane of cells, ion channels are also present in the membranes of intracellular organelles. These ion channels, also known as intracellular "i" ion channels, regulate several vital cellular functions by modulating ion fluxes across different intracellular organelles. A major focus of our group is to establish the molecular identities of intracellular ion channels, study their biophysical properties and their physiological roles. We are investigating the role of "i" channels in cardioprotection, cardiac function and aging.

Images from the Singh Lab at Drexel University College of Medicine.

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