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B. Timothy Himes

B. Timothy Himes, PhD

Research Assistant Professor


Department: Neurobiology & Anatomy

Education

  • PhD - Medical College of Pennsylvania
  • Postdoctoral Fellowship - Medical College of Pennsylvania

B. Timothy Himes, PhD, is a research assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. He is an instructor in the Gross Anatomy, Microscopic Anatomy and Neuroanatomy threads of the first-year medical school curriculum, and is a facilitator in the Cased Based Learning (CBL) course for first-year medical students. He is also a lecturer in Medical Neuroscience (NEUR 602S).

Research Interests

Recovery of function after spinal cord injury

Research

The goal of Dr. Himes' research has been to understand the mechanisms that contribute to recovery after spinal cord injury and to use this knowledge to develop rational clinical treatments. The emphasis was in the use of adult-derived mesenchymal stem cells as transplants to augment host tissue survival and improve functional recovery following SCI. The effects of adult-derived stem cells in the repair of SCI would be particularly interesting because such cells are readily available and could be generated from the individuals own tissue, avoiding the problem of graft rejection of foreign tissue by the host. Currently Dr. Himes devotes his efforts to teaching.

Publications

Selected Publications

“Implications of poly(N-isopropylacrylamide)-g-poly(ethylene glycol) with codissolved brain-derived neurotrophic factor injectable scaffold on motor function recovery rate following cervical dorsolateral funiculotomy in the rat”
Grous LC, Vernengo J, Jin, Y, Himes BT, Shumsky JS, Fischer I and Lowman, A
Journal of Neurosurgery. Spine 18 (6), 641-52. PMID: 23581453, 2013

“A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord”
Conova L, Vernengo J, Jin Y, Himes BT, Neuhuber B, Fischer I, and Lowman A
J Neurosurg Spine 15, 594-604. PMID: 21888482, 2011

“Inhibition of Kinesin-5, a Microtubule-Based Motor Protein, As a Strategy for Enhancing Regeneration of Adult Axons”
Lin S, Liu M, Son, Y-J, Himes, BT, Snow D M, Yu W, and Baas PW
Traffic 12(3):269-286. PMID 21166743. 2011

“In vivo imaging of dorsal root regeneration: rapid immobilization and presynaptic differentiation at the CNS/PNS border”
Di Maio A, Skuba A, Himes BT, Bhagat SL, Hyun JK, Tessler A, Bishop D and Son YJ
J Neurosci. 2011 Mar 23;31(12):4569-82. PMID: 21430157. 2011

“Live imaging of dorsal root axons after rhizotomy”
Skuba A, Himes BT and Son, YJ
Journal of Visualized Experiments: JoVE (55):e3126. PMID: 21912366. 2011

“Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury”
Jin Y., Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli J, and Fischer I
J. Neurotrauma 28(4):579-594. PMID 21222572, 2011

"Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia"
Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D and Baas PW
J. Neurosci. 28(9):2147-2157. PMID: 2693295. 2008

“Pathophysiology of Spinal Cord Injury”
Himes, BT
In: Spinal Trauma: Imaging, Diagnosis and Management, Schwartz E and Flanders AE (eds.), Philadelphia: Lippincott Williams & Wilkins, 2007

"Recovery of function following grafting of human bone marrow stromal cells into the injured spinal cord"
Himes BT, Kopen GC, Coleman C, Kushner R, Swanger S, Neuhuber B, Bakshi A, Shumsky JS, Wagner J, and Fischer I
Neurorehabilitation and Neural Repair. 20(2):278-296, PMID: 16679505. 2006

"Role of the 5-HT2C receptor for improving weight supported stepping in adult rats spinalized as neonates"
Kao T, Shumsky J, Jacob-Vadakot S, Himes BT, Murray M, Moxon K
Brain Res. 1112:159-168, PMID: 16914121. 2006

"Structure of the Excitatory Receptive Fields of Infragranular Forelimb Neurons in the Rat Primary Somatosensory Cortex Responding To Touch"
Tutunculer B, Foffani G, Himes BT and Moxon KA
Cerebral Cortex 16(6):791-810, PMID: 16120794. 2006

"Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury"
Park KI, Himes BT, Stieg PE, Tessler A, Fischer I and Snyder EY
Exp. Neurol. 199(1):179-190, PMID: 16714016. 2006

"Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations"
Neuhuber B, Himes BT, Shumsky JS, Gallo G and Fischer I
Brain Res. 1035(1):73-85, PMID: 15713279. 2005

"Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord"
Swanger SA, Neuhuber B, Himes BT, Bakshi A and Fischer I
Cell Transplantation. 14(10):775-786, PMID: 16454352. 2005

"Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury"
Bakshi A, Fisher O, Dagci T, Himes BT, Fischer I and Lowman A
J. Neurosurg. Spine 1(3):322-329, PMID: 15478371. 2004

"New model of minimally invasive experimental spinal cord injury"
Schwartz ED and Himes BT
Am. J. Neuroradiol. 24(2): 166-168, PMID: 12591628. 2003

"Grafts of BDNF-producing fibroblasts that promote regeneration of axotomized rubrospinal neurons also rescue most neurons from retrograde death and prevent their atrophy"
Liu Y, Himes BT, Murray M, Tessler A and Fischer I
Exp. Neurol. 178(2): 150-164, PMID: 12504875. 2002

"Transplants of cells genetically modified to express neurotrophin-3 (NT-3) rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats"
Himes BT, Liu Y, Solowska JM, Fischer I and Tessler A
J Neurosci Res. 65:549-564, PMID: 11550223. 2001

"Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: distinct transport rates of different isoforms"
Ma D, BT Himes, TB Shea, and I Fischer
J. Neurosci. 20:2112-2120, PMID: 10704485. 2000

"Neuroprotection from cell death following axotomy"
Himes BT and A Tessler
In Nerve Regeneration, Ingoglia N and Murray M (eds.). New York: Marcel Dekker, 2000

"Analysis of multipotential stem cells from embryonic rat spinal cord: in vitro characterization and intraspinal grafting"
Chow SY, Moul J, Tobias CA, Himes BT, Liu Y, Obrocka M, Hodge L, Tessler A and Fischer I
BrainRes. 874:87-106, PMID: 10960593. 2000


Contact Information


Research Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8309
Fax: 215.843.9082