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Michael White

Michael White, PhD

Professor


Department: Biochemistry & Molecular Biology

Education

  • PhD in Biochemistry - Brandeis University (1982)

Dr. White's current educational roles include serving as course director for the Medical Biochemistry course in the PIL track, as well as significant teaching roles in the Medical Physiology and Medical Pharmacology courses in both the IFM and PIL tracks. He is particularly interested in applications of simulation systems in medical student teaching using the IBX Medical Simulation Center at Drexel.

Research Interests

Ligand-gated ion channels; structure-function relationships; molecular modeling; ligand-receptor interactions

Research

Prior to transitioning to full-time teaching in 2012, Dr. White's laboratory investigated structure-function relationships in ligand-gated ion channels using a combination of molecular biology, biochemistry, and electrophysiology. The bulk of the lab's effort was focused on delineating structural features of the ligand-binding domain of the serotonin type 3 receptor (5-HT3R) and the nicotinic acetylcholine receptor (AChR).

In the Media

Publications

Selected Publications:

"Expression of a biologically-active conotoxin PrIIIe in E. coli"
Hernandez-Cuebas L, and White MM
Protein Expr Purif. 82:6-10 (2012)

"Role of key aromatic residues in the ligand-binding domain of α7 nicotinic receptors in the agonist action of β-amyloid"
Tong M, Arora K., White MM, and Nichols RA
J Biol Chem 286:34373-34381 (2011)

"Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using 'molecular rulers'"
Nyce HL, Stober ST, Abrams CF, and White MM
Biophysical J. 98:1847-1855 (2010)

"Cholesterol depletion activates rapid internalization of submicron-sized acetylcholine receptor domains at the cell membrane"
Borroni V, Baier CJ, Lang T, Bonini I, White MM, Garbus I, and Barrantes F
Mol. Membr. Biol. 24:1-15 (2007)

"The role of Loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine3A receptors"
Zhang R, Wen X, Militante J, Hester B, Rhubottom HE, Sun H, Leidenheimer NJ, Yan D, White MM, and Machu TK
Biochemistry 46:1194-1204 (2007)

"Pretty subunits all in a row: Using concatenated subunit constructs to force the expression of receptors with defined subunit stoichiometry and spatial arrangement"
White MM
Mol. Pharmacol. 68:365-371 (2006)

"Mapping residues in the ligand-binding domain of the 5-HT3 receptor onto d-tubocurarine structure"
Yan D, Meyer J, and White, MM
Mol. Pharmacol. 70:571-578 (2006)


Contact Information


Research Office

Department of Biochemistry & Molecular Biology
245 North 15th Street
Mail Stop 497
Philadelphia, PA 19102
Phone: 215.762.2355
Fax: 215.762.4452