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Academic Events

  • Athlete Wellness or Athlete Burnout: Thinking Long Term About Athlete Success

    Wednesday, January 29, 2020

    12:00 PM-1:00 PM

    This webinar will be held exclusively online. Please register to receive log in information.

    • Everyone
    Come join the Drexel Sport Coaching Leadership program as we host a webinar that takes a serious look at how coaches are being trained to view the young athlete from a long-term perspective and to help them enjoy and engage in sport for life. This discussion will focus on utilizing the USOPC American Development Model and how the model has influenced organizations like US Ice Hockey and US Lacrosse. In addition, this interactive webinar will also cover ways coaches can promote athlete learning on not only the fundamental physical development skills, but also through social and behavioral skills, to keep them engaged in sport for life. Registration is listed below. All are welcome. Come join us!
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  • Molecular & Cell Biology & Genetics Seminar

    Wednesday, January 29, 2020

    1:00 PM-2:00 PM

    New College Building Geary Auditorium A 245 N. 15th Street

    • Graduate Students
    • Faculty

    Presented By
    David Pellman, professor of cell biology, Harvard Medical School

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  • Math Colloquium: Planar front Instabilities of the Bidomain Allen-Cahn Equation

    Wednesday, January 29, 2020

    3:00 PM-4:00 PM

    Korman Center, Room 243, 15 S. 33rd Street, Philadelphia, PA 19014

    • Everyone

    Yoichiro Mori, University of Pennsylvania

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  • Surface Property of Nanomaterials: A Critical Parameter for Nanomedicines

    Wednesday, January 29, 2020

    4:00 PM-5:30 PM

    Papadakis Integrated Sciences Building (PISB), Room 120, located on the northeast corner of 33rd and Chestnut Streets.

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff

    BIOMED Seminar

    Title:
    Surface Property of Nanomaterials: A Critical Parameter for Nanomedicines
     
    Speaker:
    Hao Cheng, PhD
    Associate Professor
    Department of Materials Science and Engineering (MSE)
    College of Engineering
    Drexel University

    Details:
    Nanomaterials have broad biomedical applications. Although their physicochemical properties, such as shape, size, elasticity, and surface chemical composition, are known to be pivotal in the design of nanomedicines, the impact of dynamic topographical structure of nanomaterials has not been studied. In this talk, I will show the importance of this new parameter for nanomedicine design.

    We have found that nanomaterials blood circulation time could be dramatically extended by controlling the dynamic topographical structure of polyethylene glycol (PEG) shell on nanoparticles. Regular high density PEG shell does not have this effect. Surprisingly, our studies reveal that the dynamic effect extends nanoparticle blood circulation via reduced nanoparticle uptake by liver sinusoidal endothelial cells (LSECs) instead of macrophages. The dynamic PEG layers reduce protein binding affinity to nanoparticles. This property can be used to enhance nanoparticle penetration in mucus.

    One of the major challenges of nanomedicines in cancer therapy is the inefficient diffusion of drug nanocarriers in solid tumors due to the high density of extracellular matrix in tumors. One old strategy is to conjugate matrix degrading enzymes on nanoparticle surfaces as the enzymes remove barriers for nanoparticle diffusion. However, successful animal studies have not been demonstrated. One reason is the conjugation of bioactive molecules on nanoparticle surfaces often reduces their blood circulation. We show that the problem can be circumvented by embedding matrix degrading enzymes in the PEG shell with dynamic structure instead of presenting the enzymes on the outmost surface of nanoparticles.

    The effects of prolonged nanoparticle blood circulation and enhanced diffusion in solid tumors dramatically increased nanoparticle accumulation and penetration in tumors, leading to a highly efficient antitumor efficacy. Thus, our platform technology of controlling topographical structure of nanocarriers may be valuable to enhance the clinical efficacy of a broad range of drug nanocarriers. In addition, I will briefly discuss our study on using nanoparticles to induce antigen-specific immune tolerance for treating autoimmune diseases.

    Biosketch:
    Hao Cheng, PhD, is an Associate Professor in the Department of Materials Science and Engineering at Drexel University. He received his BE and MS degrees in Chemical Engineering from Tsinghua University in 1999 and 2001, respectively. Dr. Cheng completed his PhD in Materials Science and Engineering from Northwestern University in 2005.

    Prior to joining Drexel University in 2012, Dr. Cheng was a postdoctoral associate at Northwestern University and MIT. His laboratory focuses on cell membrane-derived hydrogels, long circulating nanoparticles, and biomaterials/biological materials for inducing antigen-specific immune tolerance.

    As a corresponding author, Dr. Cheng has published in journals such as ACS Nano, Nano Letters, Nature Communications, and Advanced Drug Delivery Reviews. He was a recipient of the inaugural Nano Research Young Innovators Award in Nanobiotechnology in 2018.

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  • Fireside Chat with Dan Fitzpatrick

    Wednesday, January 29, 2020

    5:00 PM-7:00 PM

    Gerri C. LeBow, Suite 722 3220 Market Street Philadelphia, PA 19104

    • Everyone
    Join the Drexel Solutions Institute for a Fireside Chat with Dan Fitzpatrick, President - Mid-Atlantic Region, of Citizens Bank as he provides an overview of his career and how the future of work is impacting the banking industry.

    Moderated by Raquel Arredondo, Associate Director of Outreach, Engagement, &Professional Development, this intimate discussion will include an audience Q&A to provide guests with invaluable industry and career insight.
     
    This event is part of Citizens Bank's Corporate Partner of the Month activities for January. All students, staff, alumni, faculty and friends of Drexel University are encouraged to attend. 
     

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