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Events Calendar

  • Vision2020Votes

    Thursday, June 4, 2020

    12:00 AM-12:00 AM

    Everywhere

    • Everyone

    Let's Break the Record for Women Voting!

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  • Graduate College Zoom Room Office Hours

    Thursday, June 4, 2020

    12:00 AM-12:00 AM

    Zoom (Link TBA, Please RSVP)

    • Graduate Students

    Join us for our Zoom Room Office Hours featuring the Graduate College staff and a variety of guest speakers and topics of interest to the graduate community.

    Grab a cup of coffee or tea and join us for casual conversations and check-ins throughout the term.

    Talk with your peers and professionals about how your term is going, get answers to FAQs and more.

    RSVP for schedule and Zoom links: https://drexel.qualtrics.com/jfe/form/SV_2aBz1ORVpO57ikJ

    Or contact graduatecollege@drexel.edu

    Please RSVP at the link and we will send you the schedule and links to upcoming Zoom Room office hours and invite you to share your topic ideas.

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  • Helms Academy

    Thursday, June 4, 2020

    9:00 AM-5:00 PM

    The Dornsife Center for Neighborhood Partnerships 3509 Spring Garden Street, Philadelphia, PA 19104

    • Everyone
    • Parents & Families

    Goodwill Industries in partnership with Community College of Philadelphia provide a zero-cost community-based educational opportunity for adults over 18 to attain their high school equivalency credentials and up to 30 college credits, right at the Dornsife Center. Meeting students where they are, dedicated staff members provide the extensive support services needed to help participants complete the program and create their own strategy for personal success. Open Monday through Friday from 9:00 a.m. to 5:00 p.m. For more information call (215) 571-4011 or stop by room C201 at the Dornsife Center. 

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  • Riki McDaniel, MS Thesis Defense

    Thursday, June 4, 2020

    9:00 AM-11:00 AM

    https://drexel.zoom.us/j/98653292311

    • Everyone

    MXene-Polymer Nanocomposites via Thiol-Based “Click” Chemistry

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  • Citizen, Soldier, Diplomat: An Exhibition on the Life & Career of Anthony J. Drexel Biddle, Jr.

    Thursday, June 4, 2020

    9:00 AM-7:00 PM

    Main Building, 3rd Floor, Rincliffe Gallery & A.J. Drexel Picture Gallery 3141 Chestnut Street Philadelphia, PA 19104

    • Everyone
    The Drexel Collection galleries are closed until further notice. When the Collection reopens this exhibition will run through June 26. Supplementary materials for the exhibition are on view in the A.J. Drexel Picture Gallery. The gallery is open 9-5PM on January 7th, 9th, 14th, 21st, 28th & 30th; February 4th, 6th and March 2nd, 13th. Extended hours from 1pm-5pm on March 10th, 12th, 16th, 20th and April 17th, 23rd, 24th, and 30th. Outside of these dates the Picture Gallery has limited hours of Monday - Friday 3:30-5pm. 
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  • March 1 – November 4: Seat at the Table Exhibition

    Thursday, June 4, 2020

    10:00 AM-6:00 PM

    Kimmel Center 300 S. Broad Street Philadelphia, PA 19102

    • Everyone

    Women 100, a program of Vision 2020, is hosting "Seat at the Table," an exhibition that commemorates the 19th Amendment — establishing women’s right to vote — and asks 100 years later, “Where are we now?”  Visitors will experience the current status of gender equality in the U.S. through 3D infographic furniture.

    "Seat at the Table" will be presented in the lobby of the Kimmel Center daily from 10 a.m. to 6 p.m. from March 1 through November 4, 2020.

    Learn more about Seat at the Table

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  • The Community Wellness HUB

    Thursday, June 4, 2020

    10:00 AM-6:00 PM

    The Dornsife Center for Neighborhood Partnerships 3509 Spring Garden Street Philadelphia, PA 19104

    • Everyone

    The Community Wellness HUB is a place-based, community-driven, health promotion partnership between Drexel University and the residents of Mantua and Powelton Village. The HUB seeks to HEAL the community through preventative care, UNITE the community around better health, and BRIDGE the community to health services and health education programming, while tackling the social determinants that underlie their health disparities. Health education, screening, counseling and referral services are available Tuesdays to Thursdays between 10:00 a.m. to 6:00 p.m. Additional services include: 

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  • Ten at 10: Thankful Thursdays (1 Wellness Incentive Point Per Day)*

    Thursday, June 4, 2020

    10:00 AM-10:10 AM

    Online, please visit our website for more information: https://drexel.edu/hr/benefits/a-healthier-u/ten-at-10/

    • Faculty
    • Staff
    Thursdays are "Thankful Thursdays." Visit the Ten at 10 Website to connect with resources that can help you take advantage of a simple but powerful body-mind reset. Please visit our website and click on "Thankful Thursdays" to learn more.
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  • Cell Surface Env Transformation and Membrane Disruption by HIV-1 Entry Inhibitors

    Thursday, June 4, 2020

    10:00 AM-12:00 PM

    Remote

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff

    BIOMED PhD Thesis Defense

    Title:
    Cell Surface Env Transformation and Membrane Disruption by HIV-1 Entry Inhibitors
        
    Speaker:
    Charles G. Ang, PhD Candidate
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Advisors:
    Irwin Chaiken, PhD
    Professor of Biochemistry and Molecular Biology
    College of Medicine
    Drexel University

    Ken Barbee, PhD
    Professor, Senior Associate Dean, and Associate Dean for Research
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Details:
    This work examined transformations of the HIV-1 fusion protein Env and its anchoring membrane that can be subverted by lytic entry inhibitors to inactivate Env on viruses and cells. Two entry inhibitors were investigated: KR13 and M*DAVEI. KR13 is a chemically synthesized peptide triazole thiol (PTT) comprised of a CD4 binding site pharmacophore linked to a disulfide-targeting thiol, while M*DAVEI is a chimeric recombinant protein containing a gp120-glycan-binding lectin linked to Trp3, a gp41-binding fragment of Env’s membrane proximal external region (MPER). Both inhibitors have previously been shown to cause virus lysis, indicating that they can trigger membrane disruption. Env-presenting cells were selected for these experiments to facilitate mechanistic studies and provide preliminary data for further cell-based studies.

    To investigate KR13, we developed a flow cytometry protocol to examine the nature of its Env rearrangements by measuring changes in epitope availability for key regions of Env upon treatment with serial dilutions of KR13 or its thiol-blocked analogue KR13b. HEK293T cells were transiently transfected for surface presentation of JRFL Env and pre-loaded with fluorescent dye. Epitopes examined were: intact gp120-gp41 association (Ab 35O22), formation of the 6HB (Ab NC-1), MPER exposure (Ab 10E8), the immunodominant loop (Ab 50-69), fusion peptide (Ab VRC34.01), and membrane disruption (loss of intracellular dye). Env transformations caused by KR13 resembled several steps of native fusion, including loss of attached gp120, increase in 6HB detection, increase in MPER exposure, and membrane disruption, suggesting that the mechanism by which KR13 induces transformation may incorporate and subvert the conformational “program” Env uses to enter target cells. In turn, KR13 and PTT compounds in general may be useful not only as antagonist leads but also as probes to interrogate HIV entry and the exposure of key post-fusion epitopes from the unique approach of transforming Env and membrane without target cells. Further experiments with KR13 and KR13b showed that the membrane disruption and leakage effects of KR13 could be recapitulated by the combination of KR13b and the redox protein Thioredoxin-1 (Trx1). Virions were treated with either KR13 alone, or a combination of fixed concentration KR13b and serial dilutions of Trx1, showing comparable p24 release between the two. Along with literature showing Trx1’s presence in and necessity to native fusion, we established that the KR13’s free terminal thiol may be mimicking the reducing effects of Trx1, likely targeting Env’s C296-C331 disulfide.  

    The second part of this research examined the engineered protein M*DAVEI, which causes severe membrane disruptions in virions, speculated to result from the dual engagement of Env by the gp120-binding lectin and the MPER/membrane-interacting Trp3. We investigated whether the destructive effect of lectin-DAVEI on viruses could be used to target cells presenting Env on their surfaces. HEK293T cells were transiently transfected with DNA encoding JRFL Env, pre-loaded with calcein dye, treated with serial dilutions of M*DAVEI, and stained for intact gp120-gp41 association (Ab 35O22). The observed effects of M*DAVEI on cells were proportional to individual levels of Env expression: "Low-Env" cells experienced transient poration and calcein leakage, while "High-Env" cells died. Transfection with increasing quantities of Env DNA showed further shifts toward "High-Env" expression and its associated cytotoxicity. Controls with unlinked M*DAVEI components showed no effect on calcein leakage or cell viability, confirming covalently linked DAVEI components as necessary to induce transformation.  

    Cumulatively, this work has demonstrated Env metastability as an intrinsic property of the transmembrane protein complex and not limited to fusogenic or fusion-like transformations of Env alone. As such, the Env-membrane complex can be perturbed to trigger membrane disruption in virus and cell contexts, an extension of our understanding of these entry inhibitors’ effects and their mechanisms of action.

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  • Legal Studies: Graduate Programs Online Open House

    Thursday, June 4, 2020

    12:00 PM-1:00 PM

    Online

    • Everyone

    Audrey Woods, Assistant Dean of Enrollment Management, Thomas R. Kline School of Law, will be sharing information and answering questions about Drexel University’s online Legal Studies programs, which include:

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