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Biotechnology (BIOT) Related Research

Clifford Lab

Clifford Lab image of gene expression and cell proliferation. Area of Interest: Gene Expression and Manipulation

The Clifford Research Lab at Drexel University College of Medicine has a long-standing interest in regulation of gene expression and cell proliferation as they relate to cancer. Early work focused on the transcriptional regulation of genes that lack a TATA element in their promoter, which was once thought to be a canonical feature. Visit the Clifford Lab.


Bouchard Lab

Bouchard Lab image of HBV-infected hepatocytes. Area of Interest: Imaging/Microscopy

Liver cancer is one of the most common cancers worldwide. While the exact molecular mechanisms that are associated with the development of liver cancer are not entirely understood, potential causes include exposure to environmental toxins and drugs, alcohol consumption, and chronic infections of the liver with viruses such as the hepatitis B virus (HBV). The work in my laboratory focuses on studying processes involved in hepatocyte transformation; hepatocytes are the major epithelial cell of the liver. Visit the Bouchard Lab.


Simon Cocklin, PhD

Blood samples for testing. Areas of Interest: Protein Expression and Purification; Protein-protein and Protein-ligand Interaction with SPR

Research in my laboratory is focused upon two main areas of HIV-1 research: small-molecule inhibitor discovery and the identification and investigation of host cell proteins that critically interact with the HIV-1 Gag protein. We have adopted a multidisciplinary approach to researching these areas, combining data from computational, biochemical, biophysical, virological, and structural investigations to achieve our goals. Learn more about Dr. Cocklin.


Patrick J. Loll, PhD

Human cell, magnified. Areas of Interest: Protein Expression and Purification; Crystallography (sample preparation, crystallization)

Research in my lab revolves around molecular structure. The underlying goal for all our projects is to understand biologically important processes at the molecular level. Our principal tools are biophysical ones, including in particular X-ray crystallography; we also devote much energy to protein expression and protein biochemistry to support the structural efforts. Learn more about Dr. Loll.


Reginato Lab

Images related to research at the Reginato Lab. Areas of Interest: Gene Expression and Manipulation; Imaging/Microscopy

Breast cancer is the second leading cause of cancer death in women. About 1 in 8 women in the U.S. will develop invasive breast cancer during her lifetime. Our lab is interested in understanding altered signaling pathways that lead to breast cancer initiation and progression. Identifying and understanding these pathways will lead to development of novel therapies. Recently our lab has become interested in understanding how signaling pathways regulate metabolic reprogramming in cancer cells. Visit the Reginato Lab.


Todd Strochlic, VMD, PhD

Cancer Cell Area of Interest: Gene Expression and Manipulation

The work in Dr. Strochlic's lab is broadly centered on understanding certain protein kinase-mediated cell signaling pathways in the context of normal development and tumorigenesis. The lab uses a combination of genetic, biochemical, and cell biological approaches in both Drosophila melanogaster and mammalian cells to investigate the biology of several different protein kinases. Learn more about Dr. Strochlic.

A Biotechnology program graduate student at Drexel University College of Medicine.