Alisa Morss Clyne is director of the Vascular Kinetics Laboratory, which investigates integrated mechanical and biochemical interactions among cells and proteins of the cardiovascular system. She is particularly interested in how endothelial cell mechanotransduction changes in a diseased environment, and how fluid shear stress and substrate mechanics affect biochemical binding kinetics, transport, and signaling. Dr. Clyne received her bachelor’s degree in Mechanical Engineering from Stanford University in 1996. She worked as an engineer in the GE Aircraft Engines Technical Leadership Program for four years, concurrently earning her Master’s degree in Mechanical Engineering from the University of Cincinnati. In 2006, she received her Doctorate in Medical and Mechanical Engineering from the Harvard-MIT Division of Health Sciences and Technology. In 2014, she completed the Executive Leadership in Academic Technology and Engineering (ELATE) program. Dr. Clyne received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. She has received research and educational funding from NSF, NIH, AHA, Department of Education, the Nanotechnology Institute, and the State of Pennsylvania, and she has published in diverse journals including Lab on a Chip, Journal of Biomechanics, Annals of Biomedical Engineering, Tissue Engineering, Biophysical Journal, PLOSOne, JBC, and Circulation. She is a fellow of ASME and the AHA, and a member of ASEE, BMES, NAVBO, and SWE. Her teaching focuses on mechanical engineering applications in biological systems, and she founded several programs to enhance diversity within engineering.
Degrees / Education
- PhD, Mechanical and Medical Engineering, Harvard-MIT Division of Health Sciences and Technology, 2006
- BS, Mechanical Engineering, Stanford University, 1996
Biomechanics of Cardiovascular disease
Areas of Study
- 2018 Curie Lecture, University of Florida
- 2017 Fellow, American Heart Association
- 2017 Elizabeth Bingham Award, Association for Women in Science
- 2016 Fellow, American Society of Mechanical Engineers
- 2016 Drexel STEM Teaching Award
- 2015 HHMI STEM Education Travel Award
- 2013 ELATE Leadership Fellow
- 2011 BMES-CMBE Rising Star Award
- 2009 Louis and Bessie Stein Fellow
- 2008 National Science Foundation CAREER Award
- 2008 Drexel University International Travel Award
- 2006 Harvard-MIT Health Sciences and Technology Graduation Speaker
- 2006 Sigma Xi Scientific Honor Society
- 2005 Distinguished Service Award, MIT Faculty Committee on Student Life
- 2004 MIT Carroll Wilson Award
- 1999 GE Outstanding Engineer Award
- 1995 Tau Beta Pi
- 1995 Cap and Gown Stanford Women’s Honor Society
- 1994, 1995 Motorola “Best in Class” Scholarships
- 1994 Stanford Engineering Dean’s Leadership Scholarship
- 1993 National Society of Women Engineers Scholarship
- 1992 National Society of Professional Engineers Scholarships
- 1992 National Merit Scholarship
- 1992 Girl Scout Gold Award
- Urbano R, Furia C, Basehore S, Morss Clyne A. (2017) Stiff substrates increase inflammation-induced tension and permeability in endothelial monolayers. Biophysical Journal, 113(3): p. 645-655.
- Swaminathan S, Ngo O, Basehore S, Morss Clyne A. (2017) A vascular endothelial – breast epithelial cell co-culture model created from 3D cell structures. ACS Biomaterials Science and Engineering, 3(11): p 2999-3006.
- Mathew J, Basehore S, Morss Clyne A. (2017) Fluid shear stress and fibroblast growth factor-2 increase endothelial cell-associated vitronectin. Applied Bionics and Biomechanics, Article ID 9040161.
- Canver A, Morss Clyne A. (2017) Quantification of multicellular organization, junction integrity, and substrate features in collective cell migration. Microscopy and Microanalysis, 23(1), p. 22-33.
- Morss Clyne A, Billiar K. (2016) Problem-based learning in biomechanics: advantages, challenges, and implementation strategies. Journal of Biomechanical Engineering, 138(7). Selected as Editors' Choice paper for 2016 (10 selected out of 168)
- Canver A, Ngo O, Urbano R, Morss Clyne A. (2016) Endothelial cell collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions. Journal of Biomechanics, 49(8): p. 1369-80.
- Urbano R, Morss Clyne A. (2016) An inverted dielectrophoretic device for analysis of attached single cell stiffness. Lab on a Chip, 16: p. 561-573.
- Mathew J, Morss Clyne A. (2015) Fibroblast growth factor-2 does not rescue plasminogen system activity or capillary-like tube formation in endothelial cells on glycated collagen. Biochemistry and Biophysics Reports, 4: p. 104-110.
- Figueroa D, Kemeny S, Morss Clyne A. (2014) Glycated collagen decreased extracellular matrix fibronectin alignment in response to cyclic stretch via interruption of actin alignment. Journal of Biomechanical Engineering, 136(10). Selected as Editors' Choice paper for 2014 (9 selected out of 187)
- Kemeny S, Figueroa D, Morss Clyne A. (2013) Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoSOne, 8(6): e66176.