Significant advances in modern technology have enabled scientists to explore and comprehend nature at a level of detail never dreamed of. To continue this fast-paced progress, the development of novel strategic methodologies to address complex scientific questions is imperative. Equipped with interdisciplinary approaches, my research program is centered on developing novel analytical tools and sensors and exploiting their applications in the field of bioanalytical measurements. In particular, we have been working on coupling the novel properties of various nanomaterials with conventional analytical techniques to develop:
- a new sensing modality based on amplification-by-polymerization for POC DNA diagnostics
- a label-free multiplexed biomolecule detection platform based on a hybrid of encoded nanoparticles and conjugated fluorescent polymers
- a high resolution single particle imaging tool based on plasmon-enhanced circular dichroism
- nanofeatures-facilitated mass spectrometric techniques in tissue imaging and metabolite profiling
The overarching aims of our research is to introduce new means to monitor elementary biomolecular interactions with possible ramifications in field-friendly biomolecule screening and biomolecular-facilitated photocatalytic reactions.