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Roman Fischer, PhD

Roman Fischer, PhD

Assistant Research Professor
Department of Biology
Office: PISB 413
Phone: 215.571.3785


  • Postdoctoral Fellow, University of Stuttgart, Germany, 2011-2014
  • PhD, Cell Biology, University of Stuttgart, Germany, 2007-2011
  • MS, Genetics, Friedrich-Alexander-University Erlangen-N├╝rnberg, Germany 2002-2007

Research Interests:

  • Protein engineering
  • Immunology
  • Neuroimmunology
  • Neurology

Selected Publications:

  • Fischer R, Kontermann RE, Maier O “Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy” Antibodies 2015 4(1), 48-70; doi:10.3390/antib4010048
  • Fischer R, Maier O “Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF” Oxid Med Cell Longev. 2015 doi: 10.1155/2015/610813. Epub 2015 Mar 5.
  • Fischer R, Wajant H, Kontermann RE, Pfizenmaier K, Maier O. „Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor.” Glia. 2014 Feb;62(2):272-83.
  • Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA. "Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.“ J Immunol. 2012 Sep 15;189(6):3130-9.
  • Fischer R, Maier O, Siegemund M, Wajant H, Scheurich P, Pfizenmaier K. „A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death.“ PLoS One. 2011;6(11):e27621. Epub 2011 Nov 14.
  • Fischer R, Maier O, Naumer M, Krippner-Heidenreich A, Scheurich P, Pfizenmaier K. „Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway.“ Cell Signal. 2011 Jan;23(1):161-70. Epub 2010 Aug 31.