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Fraser Fleming, PhD

Fraser Fleming, PhD

Professor of Chemistry
Department of Chemistry
Office: Disque Hall 306
Phone: 215.895.2644

Additional Sites: Fleming Group


  • Oregon State University, Post-doctoral fellow, 1990-1992
  • University of British Columbia (Canada) PhD Organic Chemistry, 1990
  • Massey University (New Zealand), BS (Hons.) Chemistry, 1986

Curriculum Vitae:

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Research Interests:

  • Rapidly constructing biologically relevant scaffolds as potential pharmaceutical leads
  • Metalated nitriles as potent nucleophiles for hindered bond construction
  • Metalated isocyanides as precursors to peptide mimics


Fraser Fleming earned his BS (Hons.) at Massey University, New Zealand, in 1986 and a PhD under the direction of Edward Piers at the University of British Columbia, Canada, in 1990. After postdoctoral research with James D. White at Oregon State University he joined the faculty at Duquesne University, Pittsburgh, in 1992. In 2013 he took a temporary position as a program director at the National Science Foundation working in the Synthesis Program and the Catalysis Program. His research interests lie in stereochemistry and organometallics, particularly as applied to the reactions of nitriles and isonitriles.

Selected Publications:

  1. "Synthesis of the Isocyanide Building Block Asmic, anisylsulfanylmethylisocyanide" Alwedi, E.; Altundas, B.; Chao, A.; Ziminsky, Z. L.; Natrayan, M.; Fleming, F. F. Org. Syn. 2020, submitted.
  2. "Asmic Isocyanide Condensations to Substituted Oxazoles" Mueller, L. G.; Chao, A.; Alwedi, E.; Natrajan, M.; Fleming, F. F. Org. Lett. 2020, ASAP.
  3. "Asmic Isocyanide [3+2] Cascade to Dihydrooxazoles and Dihydroimidazoles" Kumar, C. V. S.; Holyoke, C. W. Jr., Keller, T.; Fleming, F. F. J. Org. Chem. 2020, 85, 9153-9160.
  4. "An Acetonitrile-Hexanes Extraction Route to Pure Sulfonium Salts" Altundas, B. Kumar, C. V. S.; Fleming, F. F. ACS Omega 2020, 5, 13384-13388.
  5. "Asmic Isocyanide-nitrile Isomerization-Alkylations" Alwedi, E.; Lujan-Montelongo, J. A.; Cortés-Mejía, R.; del Campo, J. M.; Altundas, B.; Fleming, F. F. Eur. J. Org. Chem. 2019, 4644–4648.
  6. "Isocyanide Purification: C-2 Silica Cleans up a Dirty Little Secret" Chao, A.; Alwedi, E.; Fleming, F. F. Synthesis, 2019, 51, 2122-2127.
  7. "Asmic: An exceptional building block for isocyanide alkylations" Alwedi, E.; Lujan-Montelongo, J. A.; Pitta, B. R.; Chao, A.; Cortés-Mejía, R.; del Campo, J. M.; Fleming, F. F. Org. Lett. 2018, 20, 5910-5913.
  8. "Electrophile-Dependent Alkylations of Lithiated g-Alkoxyalkenenitriles" Pitta, B. R.; Steward, O. W.; Fleming, F. F. J. Org. Chem. 201883, 2753-2762.
  9. "Electrophile-Directed Diastereoselective Oxonitrile Alkylations" Chepyshev, S. V. Pitta, B. R.; Vangala, S. R.; Lujan-Montelongo, J. A.; Steward, O. W.; Fleming, F. F. Chem. Eur. J. 2018, 24, 2850-2853.

Academic Details:

Graduate Program Faculty Member

*Only Graduate Program Faculty members can mentor graduate students