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Dr. John Bethea

John Bethea, PhD

Department of Biology
Office: PISB 123.04
Phone: 215.895.2624
Lab Location: PISB 413
Lab Phone: 215.571.3785


  • BS, Biology, Florida International University, 1985
  • PhD, Neuroscience, University of Alabama at Birmingham, 1991
  • Post Doc, Neuroscience, Case Western Reserve University, 1994
  • Post Doc, Immunology, The Cleveland Clinic Foundation, 1996

Selected Publications:

  • Johnstone JT, Morton PD, Jayakumar AR, Johnstone AL, Bracchi-Ricard V, Runko E, Patel S, Pearse DD, Liebl DJ, Norenberg MD, Bethea JR Astrocyte-meidtaed NADPH-oxidase activation in oligodendrocytes induces cell death following trauma (In Press J of Neuroscience Research)
  • Morton PD, Theus MH, Bethea JR Activation of NF- kB in Schwann cells is dispensable for myelination. (In Press J of Neuroscience)
  • Jopek Ashbaugh J., Brambilla R., Karmally S., Cabello C., Malek T., Bethea JR. Interleukin-7 receptor alpha contributes to experimental autoimmune encephalomyelitis through non-hematopoietic cell lineages and altered T cell responses. (In Press, Journal of Immunology).
  • Brambilla R, Dvoriantchikova G, Barakat D, Ivanov D, Bethea JR* and Shestopalov VI* Transgenic inhibition of astroglial-NF-kB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis J Neuroinflammation 2012 (9) 213-. *co-corresponding authors
  • Bigford G, Bracchi-Ricard V, Nash MS, Bethea JR Chronic thoracic spinal cord injury inhibits leptin signaling in the hypothalamus. PLoS One 7(7) e41703 2012
  • Morton PD, Johnstone JT, Ramos AY, Liebl DJ, Bethea JR Nuclear Factor-κB Activation in Schwann Cells Regulates Regeneration and Re-myelination. GLIA. 60:639-650 2012.
  • Zhang Y, Liu J, Yao S, Li F, Xin L, Lai M, Bracchi-Richard V, Xu H, Yen W, Meng W, Liu S, Yang L, Karmally S, Liu J, Zhu H, Gordon J, Khalili K, Srinivasan S, Bethea JR, Mo X, Hu W. NFĸB Signaling Initiates Early Differentiation of Neural Stem Cells. Stem Cells. 2011.
  • Brambilla R, Ashbaugh JJ, Magliozzi R, Dellarole A, Karmally S, Szymkowski DE, Bethea JR. Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain. 134(Pt 9):2736-54 2011.
  • Candiotti KA, Yang Z, Morris R, Yang J, Crescimone NA, Sanchez GC, Bird V, Leveillee R, Rodriguez Y, Liu H, Zhang YD, Bethea JR, Gitlin MC. Polymorphism in the interleukin-1 receptor antagonist gene is associated with serum interleukin-1 receptor antagonist concentrations and postoperative opioid consumption. Anesthesiology. 114(5):1162-8 PubMed 2011.
  • Zhang YP, Fu ES, Sagen J, Levitt RC, Candiotti KA, Bethea JR, Brambilla R. Glial NF-kappa B inhibition alters neuropeptide expression after sciatic nerve injury in mice. Brain Res. 1385:38-46