Design, synthesis and properties of novel chelating agents and of macrocyclic and oligonuclear metal complexes. Bioinorganic chemistry of metalloproteins, models for various properties of Fe, Cu, Ni and V centres in O2-transporting and redox proteins. Electrochemistry, CD, EPR and magnetic properties of extended and molecular systems for thermal & photostimulated energy- and electron-transfer.
Addison has published numerous papers in the areas of metalloprotein chemistry, the chemistry of non-macromolecular active-site models of metalloproteins, and the design of novel redox-active and photoactive complexes. He maintains active collaborations with x-ray crystallographic and other research groups in the U.S. and Ukraine. Of these active collaborations Addison says, "Classical biochemistry is acceding to the reality that a large number of physiologically important biological macromolecules owe their functional activity to the presence of one or more metal ions in their structures. We are engaged in synthesis of ‘unnatural' molecules, whose behaviors are designed to reveal to us clues about the action of metal ions in such biological structures. Their roles include energy transfer or electron transfer over long distances."
Professor Addison, one of Drexel’s two token Australians, is a C. & M. Lindback Distinguished Teaching Awardee, the recipient of the 2016 ACS Philadelphia Section Research Award, a Fellow of the Royal Society of Chemistry (2008), a Fellow of the American Chemical Society (2012) and a Fellow of the Royal Australian Chemical Institute (2016). He is an officer and past chairman of the ACS Philadelphia Section, and a member of both the International EPR Society & the Canadian Society for Chemistry. He is lead author of the most-cited article published by the RSC in the field of Inorganic Chemistry in the last 115 years, as well as of several other highly-cited papers. His >240 articles and conference presentations have garnered over 10,000 citations in the research literature, a Hirsch Index of 37, an Egghe g-index of 103 & a Google i99 of 12.