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Dr. Lynn S. Penn

Lynn S. Penn, PhD

Department of Chemistry
Office: Disque Hall 211
Phone: 215.895.4970


  • AB, University of Pennsylvania, 1966
  • PhD, Bryn Mawr College, 1974

Curriculum Vitae:

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Research Interests:

Construction of complex and controlled polymer brushes for functional surfaces; experimental study of diffusion into polymer brushes and comparison with theoretical predictions; surface and interface chemistry, including wetting and adhesion; real-time monitoring and quantitative analysis of chemical reactions and adsorption on surfaces.

Selected Publications:

  • Lynn S. Penn,* “ConfChem Conference on Mathematics in Undergraduate Chemistry Instruction: Estimating – An Empowering Skill for Students in Chemistry and Chemical Engineering,” J. Chem. Educ., 95, 1426-1427 (2018). DOI: 10.1021/acs.jchemed.8b00363.
  • K. Prudnikova, S. Lightfoot-Vidal, S. Sarkar, T. Yu, R. Yucha, N. Ganesh, L. Penn L. Han, C. Schauer, E. Vresilovic, and M. Marcolongo, “Aggrecan-Like Biomimetic Proteoglycans (BPGs) Composed of Natural Chondroitin Sulfate Bristles Grafted onto Poly(acrylic acid) Core for Molecular Engineering of the Extracellular Matrix,” Acta Biomaterialia, 75, 93-104 (2018}. DOI:10.1016.actbio.2018.05.013.
  • Jennifer Chen, Lynn Penn, and Jun Xi,* “Quartz Crystal Microbalance: Sensing Cell-Substrate Adhesion and Beyond,” Biosensors and Bioelectronics, 99, 593-602, 2018. DOI: 10.1016/j.bios.2017.08.032. Recognized as a “highly cited” paper in 2018 by Web of Science. This paper has received enough citations to place it in the top 1 percent of the academic field of chemistry.
  • Sumona Sarkar, Carli Moorehead, Katsiaryna Prudnikova, Caroline Schauer, Lynn Penn, and Michele Marcolongo,* “Synthesis of Macromolecular Mimics of Small Leucine-rich Proteoglycans with a Poly(ethylene glycol) Core and Chondroitin Sulfate Bristles,” Carbohydrate Polymers, 166, 338-347 (2017). DOI: 10.1016/jcarbpol.2017.02.083.
  • Katsiaryna Prudnikova, Robert Yucha, Pavan Patel, Alicia Kriete, Lin Han, Lynn Penn, Michele Marcolongo,* "Biomimetic Proteoglycans Mimic Macromolecular Architecture and Water Uptake of Natural Proteoglycans," Biomacromolecules, 18,1713-1723 (2017).DOI: 10.1021/acs.biomac.7b00032.
  • Xue Sha, Xiaohe Xu, Karl Sohlberg, Patrick J. Loll, and Lynn S. Penn* “Evidence That Three-Regime Kinetics Is Inherent to Formation of a Polymer brush by a Grafting-To Approach,” RSC Advances, 4, 42122-42128 (2014) DOI: 10.1039/c4ra05663a.
  • Xue Sha, Chengjun Sun, Xiaohe Xu, Laura Alexander, Patrick J. Loll, and Lynn S. Penn,* “Quartz Crystal Microbalance (QCM): Useful for Developing Procedures for Immobilization of Proteins on Solid Surfaces,” Anal. Chem., 84, 10298-10305 (2012).
  • Jennifer Chen, Minghong Li, Lynn Penn, Jun Xi,* "Real-time and Label-free Detection of Cellular Response to Signaling Mediated by Distinct Subclasses of Epidermal Growth Factor Receptors," Anal. Chem., 83, 3141-3146 (2011).   
  • Hyun-Su Lee and Lynn S. Penn,* “Polymer Brushes Make Nanopore Filter Membranes Size-Selective to Dissolved Polymers,” Macromolecules, 43, 565-567 (2010).   
  • Hyun-Su Lee, Mark Contarino, M. Umashankara, Arne Schön, Ernesto Freire, Amos B. Smith III,  Irwin M. Chaiken,  and Lynn S. Penn,* “Use of the Quartz Crystal Microbalance to Monitor Ligand-induced Conformational Rearrangements in HIV-1 Envelope Protein gp120,” Anal. Bioanal. Chem., 396, 1143-1152 (2010).    
  • Hyun-Su Lee and Lynn S. Penn,* “Evidence for Radius of Gyration as the Criterion for Selective Diffusion Behavior of Polymer Brushes,” Langmuir, 25, 7983-7989 (2009).