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A Multi-disciplinary Regenerative Medicine Approach to Resolving the Donor Lung Shortage

Monday, February 19, 2018

12:00 PM-1:30 PM

BIOMED Special Seminar

A Multi-disciplinary Regenerative Medicine Approach to Resolving the Donor Lung Shortage

Jinho Kim, PhD
Associate Research Scientist
Department of Biomedical Engineering
Columbia University

Nearly 25 million people in the United States suffer from end-stage lung disease. For these patients, lung transplantation is the only intervention that can prolong survival. Unfortunately, lung transplantation is limited by the severe shortage of available donor lungs that meet functional criteria. This has led to efforts in tissue engineering and regenerative medicine that aim to recover marginal quality lungs to the point of being usable for transplantation.

With interdisciplinary approaches across surgery, medicine, and bioengineering, our laboratory has demonstrated regeneration and functional recovery of donor lungs initially unacceptable for transplantation through removal and replacement of lung epithelial cells in targeted regions of damaged lungs. We further developed minimally invasive imaging techniques that facilitated lung regeneration by allowing direct, continuous observation and evaluation of the lungs in real time. This tightly regulated cell replacement approach enabled recovery of fully functional donor lungs while maintaining perfusion and the capacity for gas exchange.

This seminar will highlight recent progress our lab has made in regeneration of functional lungs using explanted rodent, porcine, and human lung models, with an emphasis on the innovative ideas and advanced technologies created through a multidisciplinary approach to achieve this technically challenging but clinically significant goal.

Dr. Jinho Kim is an Associate Research Scientist in the Laboratory for Stem Cells and Tissue Engineering directed by Professor Gordana Vunjak-Novakovic at Columbia University Medical Center. After completing his military service in South Korea, he immigrated to the United States and attended Temple University, where he obtained a BS degree with Highest Honors in 2007 and a MS degree in 2009, both in Mechanical Engineering. In 2013, Dr. Kim earned his PhD in Mechanical Engineering from Columbia University. Since then, he has worked as a Post-Doctoral Research Scientist in the Tissue Engineering lab, where he was awarded financial support for his research from the Raymond and Beverly Sackler Foundation and the Columbia School of Engineering.

Contact Information

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