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Vandana Miller

Vandana Miller, MD

Director of Plasma Medicine Laboratory and Associate Research Professor
C. & J. Nyheim Plasma Institute

Office: C. & J. Nyheim Plasma Institute
200 Federal Street, Suite 500
Phone: 215.571.4074
Email: vam54@drexel.edu

Bio

Dr. Vandana Miller is the Director of the Plasma Medicine Laboratory at theC. & J. Nyheim Plasma Institute of Drexel University. At NPI, she spearheads all biological projects including antimicrobial applications of plasma, plasmaassisted transdermal drug delivery, treatment of skin diseas es and tissue regeneration with nonequilibrium plasma. The institute has approvals and industry and clinical partners to study DBD Plasmaassisted treatment of acne and skin restructuring for cosmetic aesthetics. Another area of research in Dr. Miller's laboratory is the use of plasma activated water in agriculture, addressing microbial contamination of food and for enhanced growth of plants. She has initiated a major shift in the philosophy of using plasmas for treatment of cancer, whereby instead of direct ablative therapy of tumors, plasma is being used to trigger immune responses within the subject’s body.

Education

Post Doc Fellow, Pathobiology,School of Veterinary Medicine, University of Pennsylvania, 1995
Post Grad Diploma, Medical Microbiology, V.P. Patel Chest Institute, Delhi University, New Delhi, 1988
MD, Medicine and Surgery, Lady Harding, Medical College, New Delhi, 1983
BS, Pre-Med, Hindu College, Delhi University, New Delhi, 1978

Professional Societies
American Society of Microbiology
International Society for Plasma Medicine
International Society of Plasma Chemistry
International Society for Plasmas in Cancer

Research Interests

Biological and medical applications of non-thermal plasma, mainly anti-microbial effects, anti-cancer effects, facilitated drug delivery, and tissue regeneration. The effects of direct plasma on mammalian cells and tissues, with emphasis on immune modulation that would subsequently influence many different systems at the organismal level.

Publications

Plasma Related Publications
  • Influence of Uniform and Non-Uniform Regimes of Nanosecond-Pulsed and Microsecond-Pulsed Dielectric Barrier Discharges on Intracellular Biochemical Processes in 10T½ Cells, Abraham Lin, Natalie Shainsky, Dayonna Park, Theresa Freeman, Danil Dobrynin, Alexander Fridman, Vandana Miller, Gregory Fridman, Bulletin of the American Physical Society, GEC 2013
  • Anti-neoplastic Effects of Non-Thermal Plasma, Vandana Miller, Danil Dobrynin, Gregory Fridman, Ari Brooks, Alexander Fridman, Proceedings of the first International Workshop on Plasma for Cancer Treatment, March 2014
  • Plasma Stimulates Angiogenesis, Michael V. Autieri, Vandana A. Miller, Danil V. Dobrynin, Alexander Fridman, Proceedings of the fifth International Conference on Plasma Medicine, May 2014
  • Plasma stimulation of migration of macrophages, Vandana Miller, Abraham Lin, Gregory Fridman, Danil Dobrynin, Alexander Fridman, Plasma, Polymers and Processes. doi: 10.1002/ppap.201400168
  • Non-Equilibrium Dielectric Barrier Discharge Treatment of Mesenchymal Stem Cells: Charges and Reactive Oxygen Species Play the Major Role in Cell Death, Abraham Lin, Natalie Chernets, Danil Dobrynin, Gregory Fridman, Theresa Freeman, Alexander Fridman, Vandana Miller, doi: 10.1002/ppap.201400232, Plasma, Polymers and Processes, 2015
  • Microsecond-Pulsed Dielectric Barrier Discharge Plasma Stimulation of Tissue Macrophages for Treatment of Peripheral Vascular Disease, V. Miller, A. Lin, F. Kako, K. Gabunia, S. Kelemen, J. Brettschneider, G. Fridman, A. Fridman and M. Autieri, manuscript accepted for publication to Physics of Plasma, May 2015
  • Plasma-Stimulated Cancer Immunotherapy, Vandana Miller, Abraham Lin, Danil Dobrynin, Gregory Fridman, Alexander Fridman, Proceedings of the second International Workshop on Plasma for Cancer Treatment, March 2015
  • Cytotoxic macrophage released tumor necrosis factor-a (TNF-a) as a killing mechanism for cancer cell death after cold plasma activation, Nagendra Kumar Kaushik, Neha Kaushik, Booki Min, Ki Hong Choi, Young June Hong, Vandana Miller, Alexander Fridman, Eun Ha Choi, J. Physics D: Applied Physics, submitted for publication, 2015
  • Uniform Nanosecond Pulsed Dielectric Barrier Discharge Plasma Enhances Anti-Tumor Effects by Induction of Immunogenic Cell Death in Tumors and Stimulation of Macrophages. Lin A, Truong B, Pappas A, Kirifides L, Chen S, Sang N, Lin S, Dobrynin D, Fridman G, Fridman A, Sang N, Miller V, Plasma Processes and Polymers: Special Issue Plasma and Cancers II, Published Oct 2015
  • Why Target Immune Cells for Plasma Treatment of Cancer, Vandana Miller, Abraham Lin, Alexander Fridman, Plasma Chemistry and Plasma Processing, Accepted for publication, Sep 2015
  Other Significant Publications
  • Characterization of the Adenosine Receptor Profile of HL 60 promyelocytes during maturation, Marina Juhel, Jessica Harakal, Vandana Miller, William Law, FASEB 2010
  • Physical and biological mechanisms of nanosecond- and microsecond-pulsed FE-DBD plasma interaction with biological objects, Azizkhan-Clifford, A Mazin, A Brooks, V Miller, T Freeman, Workshop on Weakly-ionized non-equilibrium air plasma at moderate and high pressures: generation and maintenance, modeling, diagnostics and applications, 66th Annual Gaseous Electronics Conference, September 30–October 4 2013, Princeton, New Jersey, USA
  • Novel production of terpenoids in Escherichia coli and activities against breast cancer cell lines, Shweta Gupta, Melissa G. Marko, Vandana A. Miller, Frederick Schaefer, Jennifer R. Anthony, John R. Porter, Applied Biochemistry and Biotechnology. doi 10.1007/s12010-014-1382-4
  • Apoptosis-inducing Potential of Myrothamnus flabellifolius, an Edible Medicinal Plant, on Human Myeloid Leukemic HL-60 Cells, Jasjit Dhillon, Vandana A. Miller, Jack Carter, Abeer Badiab, Chi Ngong Tang, Andy Huynh, Bela Peethambaran, International Journal of Applied Research in Natural Products Vol 7 (1) 28-32, 2014