Guadagnini attended the Sam M. Walton College of Business, University of Arkansas, and was the second woman to obtain a degree in Finance and Insurance, which was mostly an all male field. Upon graduation she became the first "in-house" Trust Officer Pension Plan Administrator in Northwest Arkansas in banking. She also became an agent with Penn Mutual Life Insurance Company, the same company her father had served as General Agent (and is still an agent). Guadagnini has been involved with the National Association of Insurance and Financial Advisors for over 26 years and is a past Board Member responsible for PR and Education and Scholarships. She has taught LUTCF courses from the American College for the insurance professionals and worked on funding projects for a scholarship with the University of Arkansas for Finance and Insurance Majors. She is currently working in a family business, handling pension plan administration, and providing life insurance products and services, for individuals and businesses. Guadagnini is an active member of the Washington County Historical Society Board as Director of Programs, and is involved with the Women’s Foundation of Arkansas Girls of Promise event for NW Arkansas in charge of recruitment and registration.
When diagnosed with Breast Cancer in 2002, Guadagnini realized the importance of early detection. While working with Komen Ozark Race for the Cure (most recently the past 2 years as the Local Sponsor Liaison) she was asked to share her story on TV. By sharing her story and speaking out on the importance of early detection she has become an advocate for women’s health issues and specifically breast cancer imaging and early detection. Most recently was the only representative for Arkansas and the only Breast Cancer survivor to speak on Capitol Hill regarding the Health Care Bill and the importance of early detection being available to all, including rural states.