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Shubha Gururaja Rao

Shubha Gururaja Rao, PhD, MSc

Research Assistant Professor

Department: Pharmacology & Physiology


  • PhD - University of Edinburgh, Queen’s Medical Research Institute, U.K. (2008)
  • BSc - Sri Siddaganga College for Women, Tumkur, India
  • MSc in Biotechnology - JB Campus, Bangalore University, India (2003)

Awards & Honors

  • Society for General Physiologists Travel Award (2014)
  • Darwin Trust PhD studentship, University of Edinburgh, U.K.
  • Junior research fellowship, Graduate Aptitude Test in Engineering (GATE), India
  • Junior research fellowship, Council of Scientific & Industrial Research (CSIR)
  • Gold Medal and National Merit scholarship by Government of India during BSc

Memberships / Professional Affiliations

  • Society of General Physiologists

Dr. Gururaja Rao is a research assistant professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine.

Research Interests

Drosophila genetics, the role of mitochondria in physiology and cancer


Dr. Shubha Gururaja Rao received her PhD from the University of Edinburgh, U.K., where she studied the role of a metalloprotease and invadolysin in chromosome condensation using Drosophila melanogaster as a model system. Her postdoctoral work at UCLA involved studying the regulation of mitochondria by oncogenic pathways. Her current general interests lie in studying the role of mitochondria in physiology, cancer and aging.

Visit the Gururaja Rao Lab.


Recent Publications

"Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein"
Shubha Gururaja Rao, Devasena Ponnalagu, Sowmya Sukur, Harkewal Singh, Shridhar Sanghvi, Yixiao Mei, Ding J. Jin, Harpreet Singh
Scientific Reports 7(1): 8500 (2017)

"Mitochondrial Changes in Cancer"
S Gururaja Rao
Handbook of Experimental Pharmacology (240), 211-227 (2016)

"Optimization of Non-Thermal Plasma Treatment in an in vivo Model Organism"
Lee A, Lin A, Shah K, Singh H, Miller V. and S Gururaja Rao
PLoS One, e0160676 (2016)

"Molecular Identity of Cardiac Mitochondrial Chloride Intracellular Channels"
Ponnalagu D, Gururaja Rao S, Farber J, Xin W, Hussain A.T, Shah K, Tanda S, Edwards J C, Berryman M, Bopassa J.C, and H. Singh
Mitochondrion, 27:6-14. (2016)

"Data supporting the specificity of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and their localization in endoplasmic reticulum of cardiomyocytes
Ponnalagu D, Gururaja Rao S, Farber J, Xin W, Hussain AT, Shah K, Tanda S, Edwards J C, Berryman M, and H. Singh
Data in Brief, 7:1038–1044 (2016)

“Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.”
Gururaja Rao S*, Janiszewski MM*, Duca E, Nelson B, Abhinav K, Panagakou I, Vass S, Heck MM
Nucl. Acids Res 43(7): 3546-3562. (2015). *Equal contribution

"Nutritional Regulation of Stem and Progenitor Cells in Drosophila"
Shim J, Gururaja Rao S, and U Banerjee
Development, 140;4647-4656 (2013)

"Oncogenic Pathway Utilizes Mitochondrial Fusion Machinery to Support Growth"
Gururaja Rao S, and U Banerjee U
Cell Cycle, 15;11(24):4491, 2012

"Control of Mitochondrial Structure and Function by the Yorkie/YAP Oncogenic Pathway"
Nargaraj R*, Gururaja Rao S*, Jones KT, Slattery M, Negre N, Braas D, Christofk H, White K, Mann R, and U Banerjee
Genes and Development, 26(18):2027-3 (2012)

"The Conserved Metalloprotease Invadolysin Localizes to the Surface of Lipid Droplets"
Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, and MM Heck
J Cell Sci. 122(Pt 18):3414-23 (2009)

"Recent Advances in Rhizobium-Legume Symbiosis"
Randhawa GS, Shubha G, Singh NK, Kumar A, and A Bhalla
Indian J Exp Biol. 41:1184-97 (2003)

"Yeast Made Somewhat Human to Produce Human Proteins"
Randhawa GS, and Shubha G
Indian J Exp Biol. 41:1352-3 (2003)

"New Insights Into DNA Transcription. Underground Strategies of an Invader; MicroRNAs Rescued From Neglect & Recent Report of a Novel Reporter"
Randhawa GS, and Shubha G
Indian J Expt Biol. 41:1500 (2003)

*Equal contributions

Contact Information

Research Office

Department of Pharmacology & Physiology
245 N. 15th Street
Mail Stop 488
Philadelphia, PA 19102
Phone: 215.762.3116
Fax: 215.762.2299