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Rita Shaughnessy

Rita Shaughnessy, MD, PhD

Associate Professor


Department: Psychiatry

Practices: Drexel Psychiatry

Specialties: Psychiatry

Education

  • MD - University of Illinois, Chicago (1989)
  • PhD - University of Illinois, Chicago (1980)
  • BA - Governors State University (1974)

Dr. Shaughnessy is director of outpatient programs. She is board certified in psychiatry with expertise in treating adults with mood disorders.

Contact Information
General Adult Psychiatry Clinic: 267.507.6581
Supportive Intensive Outpatient Treatment Program: 267.507.6800

Clinical Services

Mood Disorders, Anxiety disorders, Psychiatric evaluation, Medication management

Residencies

  • Psychiatry - University of Illinois, Chicago (1989 - 1993)

Internships

  • Psychiatry - University of Illinois, Chicago (1989 - 1993)

Rita Shaughnessy, MD, PhD, is an associate professor of psychiatry at Drexel University College of Medicine.

Research Interests

Schizophrenia (etiology and pathophysiology)

Research

Recent Federal Grants

Co-Investigator: "The Genomics of Treatment-Resistant Psychotic Symptoms"
NIMH (Current)
PIs: Patrick Sullivan and Richard C. Josiassen

Collaborator: "Ethical, Legal, and Social Implications of Translational Psychiatric Genomics Research"
NIH (Current)
PI: Gabriel Lázaro-Muñoz, PhD, JD, MBE

Collaborator: "The Genetics of Highly Treatment Resistant Schizophrenia"
NIMH (Current)
PI: Martilias Farrell, PhD

Co-Investigator: Genetic Dissection of the Heterogeneity of Schizophrenia
NIMH (Under Review)
PI: James Crowley, PhD

Recent Industry Grants

"A Phase 3, Open-Label Safety and Tolerability of NBI-98854 for the Treatment of Tardive Dyskinesia"
Period of Award: Ongoing
Grant Category: CT
Role: Co-PI
Source of Support: Neurocrine NBI 1402

"Open Label Roll Over Study for Continuing Valbenazine (NBI-98854) Administration for the Treatment of Tardive Dyskinesia"
Period of Award: Ongoing
Grant Category: CT
Role: Co-PI
Source of Support: Neurocrine NBI -1506

"An Open Label Safety and Tolerability Study of NBI-(8854 for the Treatment of Subjects with Tourette Syndrome"
Period of Award: Ongoing
Grant Category: CT
Role: Co-PI
Source of Support: Neurocrine NBI -1601

Publications

Selected Publications

"Developmental delay, schizophrenia, and early-onset dementia in a man with 22q11 deletion syndrome and Huntington’s disease"
Farrell M, Lichtenstein M, Ancalade N, Giuntivano J, Crowley JJ, Filmyer D, Lázaro-Muñoz G, Shaughnessy RA, Evans JP, Berg JS, Giamberardino S, Machenzie I, Szatkiewicz J, Josiassen RC, Sullivan PF
American Journal of Psychiatry 175(5):400-407 (2018)

"Successful Treatment of Severe Tardive Dyskinesia With Valbenazine: With A Patient’s Perspective"
Josiassen RC, Filmyer DM, Gillian J, Shah SS, Deitterich TE, Shaughnessy RA
American Journal of Case Reports 18: 1185-1189 (2017)

"Improved ethical guidance for the return of results from psychiatric genomics research"
Lázaro-Muñoz G, Farrell MS, Crowley JJ, Filmyer DM, Shaughnessy RA, Josiassen RC, Sullivan PF
Molecular Psychiatry 00: 1–9 (2017)

"Vaptans are Effective in Treating Hyponatremia in Psychotic Patients: But We Need Treatment Guidelines"
Josiassen RC, Filmyer DM, Gillean JA, Shaughnessy R
Primary Care Companion for CNS Disorders, 15 (6), e1 (2013)

"Reconsidering chronic hyponatremia in psychosis"
Josiassen RC, Filmyer DM, Geboy A, Shaughnessy R
Journal of Clinical Psychiatry, 74:3, 278-279 (2013)

"Tolvaptan: A new tool for the effective treatment of hyponatremia in schizophrenia"
Josiassen RC, Curtis J, Filmyer DM, Audino B, Shaughnessy RA
Expert Opinion in Pharmacotherapy 4: 1 -12 (2010)

"Short-term treatment with second-generation antipsychotics in first-episode psychosis: 8-week results of a naturalistic single-blind study"
Josiassen RC, Shaughnessy RA, Filmyer DM, Donohue AM, Kacso M, Finkel N, Audino B, Skuban N
Early Intervention in Psychiatry 4: 57-63 (2010)

"A Randomized, Archival, Follow-Forward Exploration of the Metabolic Syndrome in Clozapine Treated Patients"
Josiassen RC, Filmyer DM, Curtis JL, Shaughnessy RA, Kacso M, Fedde J, Cornelius MD, Joseph A, Parson R, Joseph M, Weinstein J, Skuban N, Victor T
Clinical Schizophrenia and Related Psychoses (July 2009)

"Cognitive Findings from a Double-Blind, Placebo-Controlled, Multicenter Trial of a Vasopressin V2-Receptor Antagonist in Patients with Schizophrenia and Hyponatremia" (Abstract)
Josiassen R, Goldman M, Jessani M, Shaughnessy R, Czerwicz F
NCDEU, Hollywood, Florida (2009)

"Short-term Treatment with Second-Generation Antipsychotics in First-Episode Psychosis: 8-week Results of a Naturalistic Single-Blind Study" (Abstract)
Josiassen R, Shaughnessy R, Filmyer D, Donohue AM, Kacso M, Finkel N, Skuban N
NCDEU, Hollywood, Florida (2009)

"A Longitudinal Comparison of the Metabolic Syndrome in Psychotic Patients Treated with Clozapine or First-Generation Antipsychotics" (Abstract)
Josiassen R, Shaughnessy R, Filmyer D, Kasco M, Victor T, Skuban N
NCDEU, Hollywood, Florida (2009)

"Vaspressin V2-Receptor Blockade with Tolvaptan in Schizophrenic Patients with Hyponatremia: Results from a Double-Blind, Randomized Trial"
Josiassen RC, Goldman M, Jessani M, Shaughnessy R, Czerwiec F, Orlandi C
Biological Psychiatry 64 (12): 1097-1100 (2008)

"Effects of Clozapine Treatment on the Glucose-Insulin Homeostasis in Patients with Schizophrenia" (Abstract)
Skuban N, Kacso M, Filmyer D, Davis M, Shaughnessy R, Curtis J, Cornelius MD, Josiassen R
Abstracts of the International Schizophrenia Conference, Venice, Italy (2008)

"New intramuscular (IM) aripiprazole: A new treatment option"
Josiassen RC, Shaughnessy R
Current Psychiatry 6(7): 103-106 (2007)

"Vasopressin V2-Receptor Blockade with Tolvaptan in Schizophrenic Patients with Hyponatremia: Results from a Double-Blind, Randomized Trial" (Abstract)
Josiassen RC, Goldman M, Jessani M, Shaughnessy RA, Czerwiec FS, Orlandi C
Schizophrenia Bulletin 33(2), 434 (2007)

"Clozaril-induced agranulocytosis after 11 years of treatment" (letter)
Sedky K, Shaughnessy R, Hughes T
American Journal of Psychiatry, 162:4, 814 (2005)

"Clozapine augmentation with risperdone in chronic schizophrenia"
Josiassen RC, Joseph A, Kohegyi E, Stokes S, Paing W, Shaughnessy RA
American Journal of Psychiatry, 162:1; 130-136 (2005)

"Psychobiological Reflections in Adult Psychopathology" (Book Chapter)
Josiassen RC, Shaughnessy RA
Psychopathology in Adulthood: An Advanced Text Second Edition, (eds. Alan Bellack, Michel Hersen), Allyn & Bacon, pp. 77-111 (1999)

"Electrophysiological Correlates of Mania" (Book Chapter)
Josiassen RC, Nair C, Shaughnessy RA, Shagass C
Mania (ed. Goodnick), American Psychiatric Association Press, pp.171-189 (1998)

"Psychopharmacology of neuropsychiatric disorders"
Shaughnessy, R
Psychiatric Annals, 25: 634-640 (1995)

"The neuropsychiatry of affective disorders" (Book Chapter)
Shaughnessy R
Handbook of Neuropsychiatry, (eds. M. Gaviria, T. Jobe), Year Book Medical Publishers, Chicago (1994)

"The suicidal patient" (Book Chapter)
Fawcett J, Shaughnessy R
Psychiatry: Diagnosis and Therapy, Second Edition (eds. J. Floridaherty, J.M. Davis, P.G. Janicak), Appleton Lange, East Norwalk, CT (1993)

Seiden A, Shaughnessy R
Special conditions of women, Ibid.

"Temporal lobe epilepsy and psychiatric disorders: A multivariate approach" (Abstract)
Shaughnessy R, Atkins K, Gaviria M, Penney D, Acacia N
Biological Psychiatry 3.3 (suppl), 140-141A (1993)

"The suicidal patient" (Book Chapter)
Fawcett J, Shaughnessy R
Clinical Manual of Psychiatry: Diagnosis and Therapy (eds. J. Floridaherty, J.M. Davis, P.G. Janicak), Appleton Lange, East Norwalk, CT (1993)

"Variability among brain regions in the specificity of 6-OHDA-induced lesions"
Commins DL, Shaughnessy RA, Axt KJ, Vosmer G, Seiden LS
Journal of Neural Transmission 77: 197-210 (1989)

"Red-cell lithium transport and affective disorders in a multi-generation pedigree: Evidence for transmission of vulnerability to affective disorders"
Shaughnessy R, Greene S, Pandey GN, Dorus E
Biological Psychiatry, 20: 451-454 (1985)

"Effects of water deprivation and amine depletion by 56-hydroxydopamine on locomotor activity in the rat" Seiden LS, Pachman HS, Shaughnessy R
Brain Research 337: 225-232 (1985)

"Relatives of unipolar and bipolar patients have normal pursuit"
Levy DL, Yasillo NJ, Dorus E, Shaughnessy R, Gibbons RD, Peterson J, Janicak PG, Gaviria M, Davis JM
Journal of Psychiatric Research, 10: 285-293 (1983)

"Lithiumion transport and affective disorders within families of bipolar patients: Identification of a major gene locus"
Dorus E, Cox NJ, Gibbons RD, Shaughnessy R, Pandey GN, Cloninger R
Archives of General Psychiatry 40: 545-552 (1983)

"No evidence of an association between psychiatric disorders and lithium-sodium counterflow deficiencies in families of schizo-affective patients"
Shaughnessy R, Dorus E, Pandey GN, Harris J, Davis JM
Biological Psychology, 17: 631-633 (1982)

"Platelet monoamine oxidase activity and lithium transport in families of bipolar patients"
Pandey GN, Dorus E, Shaughnessy R, Davis JM
Psychopharmacology Bulletin, 17: 88-98 (1991)

"Genetic aspects of affective disorders" (Book Chapter)
Dorus E, Shaughnessy R
Affective Disorders: Diagnosis and Management in Clinical Practice (eds. E. Val, J.A. Floridaherty, F.M. Gaviria). Year Book Medical Publishers, Chicago, pp. 165-182 (1982)

"Personality correlates of platelet monoamine oxidase activity and red-cell lithium transport"
Shaughnessy R, Dorus E, Pandey GN, Davis JM
Psychiatry Research, 2: 63-74 (1980)

"Genetic control of platelet monoamine oxidase activity: A study of normal families"
Pandey GN, Dorus E, Shaughnessy R, Davis JM
Psychiatry Research, 2: 315-321 (1980)

"Reduced platelet monoamine oxidase activity and genetic vulnerability to psychiatric disorders"
Pandey GN, Dorus E, Shaughnessy R, Davis JM
Life Sciences, 25: 1173-1178 (1979)

"Lithium transport across the red-cell membrane: A cell membrane abnormality in manic-depressive illness"
Dorus E, Pandey GN, Shaughnessy R, Gaviria M, Val E, Erickson S, Davis JM
Science, 205: 932-934 (1979)

"Lithium transport across the red-cell membrane: A study of genetic factors"
Dorus E, Pandey GN, Shaughnessy R, Davis JM
Archives of General Psychiatry, 37: 80-81 (1980)

"Low platelet monoamine oxidase activity, high red-blood cell lithium ratio and affective disorders: A multivariate assessment of genetic vulnerability to affective disorders"
Dorus E, Pandey GN, Shaughnessy R, Davis JM
Biological Psychiatry 14: 9889-993 (1979)

"Genetic control of lithium transport across the red blood cell membrane: Relationship between cell membrane function and the etiology of affective disorders" (Book Chapter)
Dorus E, Pandey GN, Shaughnessy R, Davis JM
Biological Psychiatry Today (eds. J. Obials, C. Ballus, E, Gonzalez, Monclus, et al). Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 1143-47 (1979)

Presentations

"Framework for the Return of Results to Psychiatric Genomics Research Participants: What Should Be Offered?"
Lázaro-Muñoz G, Farrell MS, Ward ET, Iglesias de Ussel MD, Filmyer DM, Finkel G, Crowley JJ, Shaughnessy RA, Josiassen RC, Juengst ET, Sullivan PF
Poster presented at the 24th World Congress, Jerusalem, Israel, October 30 – November 6, 2016

"Cost effectiveness of tolvaptan in the treatment of chronic hyponatremia in psychotic patients: Results from a two-group 12-month study"
Josiassen RC, Filmyer DM, Gillean, JA, Shaughnessy RA
Poster presentation at the 69th Annual Scientific Meeting of the Society of Biological Psychiatry, in New York, New York, May 8-10, 2014

"Co-morbid conditions in schizophrenia: New developments in the treatment of hyponatremia"
"Co-morbid conditions in schizophrenia: New developments in the treatment of tardive dyskinesia"
Josiassen RC, Filmyer DM, Gillean, JA, Shaughnessy RA
Poster presentation at the 50th Anniversary of Fuller Graduate School of Psychology, Pasadena, California, February 2014

"Efficacy and Safety of Oral Lixivaptan in the Treatment of Chronic Hyponatremia in Psychotic Patients: Results from a 6-Month Study"
Josiassen RC, Filmyer DM, Shaughnessy RA, Adams A, Alexander J, Orlandi C
Poster presentation at the 68th Annual Scientific Meeting of the Society of Biological Psychiatry, San Francisco, California, May 2013

"Chronic hyponatremia in psychosis: An unmet medical need"
Josiassen RC, Filmyer DM, Shaughnessy RA
Invited address: Otsuka, Princeton, New Jersey, December 11, 2012


Contact Information


Practice Office

Drexel Psychiatry
1427 Vine Street
8th Floor
Philadelphia, PA 19102
Phone: 267.507.6581
Fax: 215.762.6673