For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

Patrick Osei-Owusu

Patrick Osei-Owusu, PhD

Assistant Professor


Department: Pharmacology & Physiology

Education

  • PhD in Cardiovascular Pharmacology - Loyola University Chicago, Stritch School of Medicine (2006)
  • BSc (Hons) in Chemistry - University of Toronto (2000)

Awards & Honors

  • Postdoctoral Travel Award, American Society for Biochemistry and Molecular Biology for ASBMB and Experimental Biology Annual Meeting, Anaheim, Calif., April 23-28, 2010
  • Postdoctoral Travel Award, Fall International Meeting of the Microcirculatory Society, Columbia, Mo., October 16-18, 2009

Memberships / Professional Affiliations

  • American Heart Association (AHA)
  • American Physiological Society (APS)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET)

Dr. Osei-Owusu is an assistant professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine.

Research Overview

Visit the Osei-Owusu Lab

Our long-standing interest is to elucidate mechanisms by which G-protein signaling regulation plays a role in physiological and pathophysiological adaptations of the cardiovascular and renal systems.

Abnormal G-protein signaling contributes to the development and establishment of diseases of the cardiovascular and renal systems, including hypertension, chronic kidney diseases, heart failure, diabetes, and stroke. Accordingly, receptors that activate G-protein signaling pathways remain predominant therapeutic targets of cardiovascular and renal disease medications, including angiotensin receptor blockers and beta-adrenergic receptor blockers. However, current therapies are inadequate as morbidity and mortality of these diseases continue to rise worldwide.

The specific focus of research in our laboratory is to unravel novel mechanisms whereby regulation and dysregulation of G-protein signaling by regulator of G-protein signaling (RGS) proteins are involved in normal functions and diseases of the cardiovascular and renal systems. To this end, we employ an integrative physiology approach, including the use of small animal disease models, mouse genetics (knock-outs, knock-ins, transgenics, and humanized mice), telemetric blood pressure and heart rate recordings, sympathetic nerve recordings, laser-Doppler flowmetry, ex-vivo studies of the microcirculation, molecular and cellular biology, whole organ and single-cell calcium imaging, and confocal video microscopy.

Our ultimate goal is to gain more insight into the underlying causes of cardiovascular and renal diseases, which may lead to the identification of novel targets for developing new and more effective therapeutics.

Research Interests

Mechanisms of G-protein signaling regulation in physiological and pathophysiological adaptations of the cardiovascular and renal systems

Research

Dr. Patrick Osei-Owusu received his PhD from Loyola University, the Department of Molecular Pharmacology and Experimental Therapeutics. His dissertation, "Mechanisms of 5-HT1A Agonist-Mediated Reversal of Hypovolemic Shock," identified neural mechanisms that mediate the onset of the decompensatory phase of hypotensive hemorrhage in a conscious animal model of severe hemorrhage.

As a postdoctoral research associate at Washington University School of Medicine in St. Louis, Missouri, his interest was in G-protein signaling mechanisms in the cardiovascular system. He was involved in the following work:

  • Identification of the cellular mechanism that regulates RGS2 (regulator of G-protein signaling 2) protein expression level in vascular smooth muscle cells, and the mechanism whereby RGS2 is able to translocate to the plasma membrane to regulate G-protein signaling involved in vasoconstrictor response.
  • Definition of cardiac-specific role of RGS2 in maladaptive cardiac hypertrophy response to excess circulating catecholamines.
  • Discovery of a novel role for RGS2 in the vascular endothelium and how it functions in this vascular compartment to regulate vascular tone and blood pressure.

Publications

Hypotension Due to Kir6.1 Gain-of-Function in Vascular Smooth Muscle.
Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG
J Am Heart Assoc;2(4):e000365, Aug 23, 2013

Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Osei-Owusu P, Sabharwal R, Kaltenbronn KM, Rhee MH, Chapleau MW, Dietrich HH, Blumer KJ
J Biol Chem;287(15):12541-9, Apr 6, 2012

Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase.
Osei-Owusu P, Sun X, Drenan RM, Steinberg TH, Blumer KJ.
J Biol Chem;282(43):31656-65, Oct 26, 2007

The 5-hydroxytryptamine1A receptor agonist, (+)-8-hydroxy-2-(di-n-propylamino)-tetralin, increases cardiac output and renal perfusion in rats subjected to hypovolemic shock.
Tiniakov R, Osei-Owusu P, Scrogin KE.
J Pharmacol Exp Ther;320(2):811-8, Feb 2007

Role of the arterial baroreflex in 5-HT1A receptor agonist-mediated sympathoexcitation following hypotensive hemorrhage.
Osei-Owusu P, Scrogin K.
Am J Physiol Regul Integr Comp Physiol;290(5):R1337-44, May 2006

Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage.
Osei-Owusu P, Scrogin KE.
J Pharmacol Exp Ther. Jun 2004;309(3):1132-40. Epub Feb 9, 2004


Contact Information


Research Office

Department of Pharmacology & Physiology
245 N. 15th Street
Mail Stop 488
Philadelphia, PA 19102
Phone: 215.762.4145
Fax: 215.762.2299