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Jay Horrow

Jay Horrow, MD

Professor


Department: Anesthesiology & Perioperative Medicine

Specialties: Anesthesiology

Education

  • MD - University of Pennsylvania School of Medicine
  • MS in Applied Statistics - Villanova University

Awards & Honors

Awards and Honors

  • Henry Ruth Achievement Award for Education, 2002
  • Alpha Omega Alpha, 1998

Dr. Jay Horrow is a board certified anesthesiologist practicing in Center City Philadelphia.

Memberships

  • American Society of Anesthesiologists
  • Pennsylvania Society of Anesthesiologists
  • American Heart Association, professional level membership
  • Society of Cardiovascular Anesthesiologists
  • Academy of Pharmaceutical Physicians and Investigators
  • American Medical Association and Pennsylvania Medical Society

Clinical Services

Anesthesia

Fellowships

  • Cardiothoracic Anesthesiology - University of Pennsylvania

Residencies

  • Anesthesiology - University of Pennsylvania

Internships

  • Internal Medicine - New York Veterans Administration Hospital, NYU School of Medicine

Dr. Jay Horrow is a professor and former chair of the Department of Anesthesiology & Perioperative Medicine at Drexel University Colege of Medicine. He also serves as a professor of biostatistics and epidemiology in the Dornsife School of Public Health at Drexel University. He lectures on a wide range of topics pertaining to anesthesiology and medical statistics to medical students, residents and fellows from many disciplines.

Research

In addition to his work for the College of Medicine, Dr. Horrow serves as executive director of clinical development for AstraZeneca, LP, in Wilmington, Delaware. He has an interest in clinical epidemiology and biostatistics, and has also served as a consultant or advisor to numerous research firms, most recently Endo Pharmaceuticals and Johnson & Johnson.

He has served as prinicipal investigator for recent grants including:

"A randomized, double-blind comparison of oral aprepitant alone vs oral aprepitant and transdermal scopolamine for preventing postoperative nausea and vomiting"
Merck ($40,020) - 2007

"A Phase III, Multicenter, Randomized, Double-blind, Parallel Group Study to Evaluate the Safety and Efficacy of 50 mg Oral Dosing with the Neurokinin-1 Receptor Antagonist GW679769 for the Prevention of Postoperative Nausea and Vomiting in Female Subjects at High Risk for Emesis" GlaxoSmithKline - 2006

Dr. Horrow has participated in numerous official meetings with the FDA:

Sept 1, 2004: Pre-advisory committee meeting for ximelagatran (Exanta®).
Sept 10, 2004: Cardiovascular and Renal Drug Advisory Committee Meeting for ximelagatran (Exanta®) NDA. Presented efficacy data and answered questions.
Mar 16, 2005: End of Review Meeting for ximelagatran (Exanta®).
Apr 11, 2005: Communications Meeting, Offices of Drug Evaluation III and VI (Exanta®).
Oct 18, 2007: Clarification of NDA requirements for HemaStrip™ (PERLEI Medical).
Apr 20, 2009: Pre-NDA meeting for ticagrelor (BRILINTA™)
Aug  5, 2009: Pre-submission briefing for ticagrelor (BRILINTA™)
Jan 25, 2010: Special protocol assessment for PEGASUS Phase IV trial (ticagrelor)
2010: Multiple (>4) teleconferences during BRILINTA™ NDA review.
2011: EOPII Meeting for EUCLID Phase IV trial (ticagrelor)

Publications

Dr. Horrow's publications include 93 articles in peer-reviewed journals, 37 book chapters plus 1 edited monograph, 12 editorials and 27 miscellaneous monographs, more than 100 scientific abstracts and 25 letters to the editor.

Recent Articles in Peer-Reviewed Journals

"Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery Results From the PLATO (Platelet Inhibition and Patient Outcomes) Trial"
Held C, Asenblad N, Bassand JP, Becker RC, Cannon CP, Claeys MJ, Harrington RA, Horrow J, Husted S, James SK, Mahaffey KW, Nicolau JC, Scirica BM, Storey RF, Vintila M, Ycas J, Wallentin L
J Am Coll Cardiol 2011; 57: 672-84

"Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management – a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial"
James S, Roe M, Cannon CP, Cornel JH, Emanuelsson H, Horrow J, Husted S, Katus H, Morais J, Pieper KS, Steg PG, Storey RF, Stevens S, Wallentin L, Harrington R
BMJ 2011; 342:d3527.

"Ticagrelor Compared to Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial"
Mahaffey KW, Wojdyla DM, Carroll K, Becker RC, Storey RF, Angiolillo DJ, Held C, Cannon CP, James S, Pieper KS, Horrow J, Harrington RA, Wallentin L; on behalf of the PLATO Investigators
Circulation 2011; 124: 544-54

"ST Elevation Acute Coronary Syndromes in PLATO: Insights from the ECG substudy"
Armstrong PW, Siha H, Fu Y, Westerhout CM, Steg PG, James SK, Storey RF, Horrow J, Katus H, Clemmensen P, Harrington RA, Wallentin L
Circulation 2011; ePublished ahead of print.

"Cystatin-C is an independent risk predictor for death or MI in patients with STEMI – results from the PLATO study"
Akerblom A, Wallentin L, Siegbahn A, Becker RC, Budaj A, Buck K, Giannitsis E, Horrow J, Husted S, Katus H, Steg PG, Storey RF, Asenblad N, James SK
Clin Chem 2011; ePublished ahead of print

"Bleeding Complications with the P2Y12 Receptor Antagonists Clopidogrel and Ticagrelor in the PLATelet Inhibition and Patient Outcomes (PLATO) Trial"
Becker RC, Bassand JP, Budaj A, Wojdyla DM, James SK, Cornel JH, French J, Held C, Horrow J, Husted S, Jopez-Sendon J, Lassila R, Mahaffey KW, Storey RF, Harrington RA, Wallentin L
Eur Heart J 2011; 32: 2933–44

"Heart rate variability measures poorly predict atrial fibrillation after off-pump coronary artery bypass grafting"
Chamchad D, Horrow JC, Samuels LE, Nakhamchik L
J Clin Anesth 2011; 23: 451-5

"Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section. A randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation"
Chamchad D, Horrow JC, Nakhamchik L, Sauter J, Roberts N, Aronzon B, Gerson A, Medved M
J Clin Anesth 2011; 23: 361-6

"Placenta percreta with invasion of the bladder wall. Management with a multi-disciplinary approach"
Parva M, Chamchad D, Keegan J, Gerson A, Horrow J
J Clin Anesth 2010; 22: 209-12

"The impact of immediate extubation in the operating room after cardiac surgery on intensive care and hospital lengths of stay"
Chamchad D, Horrow J, Nachamchik L, Sutter FP, Samuels LE, Trace CL, Ferdinand F, Goldman SM
J Cardiothorac Vasc Anesth 2010; 24: 780-4

"Percutaneous pacemaker and implantable cardioverter defibrillator lead extraction in 100 patients with intracardiac vegetations defined by transesophageal echocardiogram"
Grammes JA, Schulze CM, Al-Bataineh M, Tesenosky GA, Saari CS, Vrabel MJ, Horrow J, Chowdhury M, Fontaine JM, Kutalek SP
J Am Coll Cardiol 2010; 55: 886-94

"Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial"
Wallentin L, James S, Storey RF, Armstrong M, Barratt BJ, Horrow J, Husted S, Katus H, Steg PG, Shah SH, Becker RC; PLATO investigators
Lancet 2010;  376: 1320-8

"Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial"
James S, Budaj A, Aylward P, Buck KK, Cannon CP, Cornel JH, Harrington RA, Horrow J, Katus H, Keltai M, Lewis BS, Parikh K, Storey RF, Szummer K, Wojdyla D, Wallentin L
Circulation 2010;122: 1056-67

Recent Book Chapters

"Coagulation Management During and After Cardiopulmonary Bypass"
Shore-Lesserson L, Horrow JC, Gravlee GP
In: Hensley FA, Martin DE, Gravlee GP: A Practical Approach to Cardiac Anesthesia, 4th ed., Philadelphia. Lippincott Williams & Wilkins, 2007

"Coagulation Testing"
Mueksch J, Horrow JC
In: Gravlee GP, Davis RF, Kurusz M, Utley JR (eds.): Principles and Practice of Cardiopulmonary Bypass,  3rd edition, Baltimore: Lippincott Williams and Wilkins,  2007: in press.

"Anesthetic Management for Myocardial Revascularization"
Okum G, Horrow JC, Hensley FA
In: Hensley FA,  Martin DE, Gravlee GP: A Practical Approach to Cardiac Anesthesia, 4th ed., Philadelphia. Lippincott Williams & Wilkins, 2007: in press

Transfusion Medicine and Coagulation Disorders"
Spiess BD, Horrow JC, Kaplan JA
In: Kaplan JA (ed.): Kaplan’s Cardiac Anesthesia, 5th ed., Philadelphia: Elsevier Saunders, 2006: 937-984

This clinician's practice is independent of Drexel University. This physician is a non-compensated member of the teaching faculty of Drexel University College of Medicine.


Contact Information


Academic Office

Department of Anesthesiology & Perioperative Medicine
245 North 15th Street
New College Building, MS 310
Philadelphia, PA 19102
Phone: 215.762.7922
Fax: 215.762.8656