For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

G. Evan Boswell, MS

Adjunct Faculty


Department: Graduate School of Biomedical Sciences and Professional Studies

Education

  • B.S. in Chemistry, University of South Florida, Tampa, FL (1979)
  • M.S. in Chemistry, Butler University, Indianapolis, IN (1984)

Evan Boswell teaches the Innovative Product Development course in the Clinical Research Organization Management (CROM) program. The course provides a foundation in new therapeutic product research and development, focusing on the process of drug and medical development from early research, discovery, and product formulation through federal safety and efficacy requirements.

He currently works for Pfizer as a principal scientist where, utilizing his skills as a certified six sigma black belt, he provides troubleshooting production support to the manufacturing plant and evaluates the impact of GMP deviations. His 30 years in the industry span drug discovery, process optimization, synthesis of clinical trial supplies, and project management. This work has yielded numerous patented discoveries in the therapeutic areas of: antidepressants, neuromuscular blockers, opioid receptor analgesics, PPAR-gamma agonists for treatment of diabetes, and novel steroids for asthma treatment.

Mr. Boswell participates in Pfizer’s community support programs as a lab host and mentor to students from the Kalamazoo Area Math and Science Center.  He is also an active member of the local section of the American Chemical Society.

In addition to bachelor's and master's degrees in chemistry, Mr. Boswell completed post-graduate courses in medicinal chemistry at UNC-Chapel Hill and a post-graduate certificate in drug development at Temple University in 2007.

Publications

Patents and Publications

Ultra-Short-Acting Neuromuscular Blockers

"Substituted Isoquinolines as Ultra-Short-Acting Neuromuscular Blockers"
Inventors: Eric C. Bigham, G. Evan Boswell, John J. Saverese, Roy A. Swaringen, Sanjey S. Patel, Eric E. Boros, Robert A. Mook Jr., Vincente Samano
US # 6,177,445 B1

"Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys"
Boros, Eric E.; Samano, Vicente; Ray, John A.; Thompson, James B.; Jung, David K.; Kaldor, Istvan; Koble, Cecilia S.; Martin, Michael T.; Styles, Virgil L.; Mook, Robert A., Jr.; Feldman, Paul L.; Savarese, John J.; Belmont, Matthew R.; Bigham, Eric C.; Boswell, G. Evan; Hashim, Mir A.; Patel, Sanjay S.; Wisowaty, James C.; Bowers, Gary D.; Moseley, Caroline L.; Walsh, John S.; Reese, Mindy J.; Rutkowske, Randy D.; Sefler, Andrea M.; Spitzer, Timothy D. GlaxoSmithKline Research & Development, Research Triangle Park, NC
Journal of Medicinal Chemistry, 46(12), 2502-2515 (2003)

"Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers"
Boros, Eric E.; Bigham, Eric C.; Boswell, G. Evan; Mook, Robert A., Jr.; Patel, Sanjay S.; Savarese, John J.; Ray, John A.; Thompson, James B.; Hashim, Mir A.; Wisowaty, James C.; Feldman, Paul L.; Samano, Vicente
Glaxo Wellcome Research and Development, Research Triangle Park, NC
Journal of Medicinal Chemistry , 42(2), 206-209 (1999)

Antidepressants

"Preparation of 2-(3, 5-difluorophenyl)-2-hyroxy-3, 5-dimethylmorpholines as antidepressants"
Inventors: J. L. Kelly, D. L. Musso, G. E. Boswell, B. R. Cooper
US #5,104,870

"Arylmorpholine, Preparation and use"
Inventors: N. B. Methta, G. E. Boswell, J. L. Kelly
US #5,648, 347

"Arylmorpholne Preparation and use"
Inventors: N. B. Mehta, G. E. Boswell, J. L. Kelley
US #5,760,22

"Synthesis, Stereochemistry and Anti-tetrabenazine Activity of Bicyclo Analogues of 2-Phenylmorpholines"
*G. E. Boswell, D. L. Musso, A. O. Davis, J. L. Kelley, F. E. Soroko and B. R. Cooper
J. Het. Chem., Vol.4 No. 1, 1813-1820 (1997)

"Synthesis and Anti-tetrabenazine Activity of C-3 Analogues of Dimethyl-2-phenylmorpholines"
*G. E. Boswell, D. L. Musso, *J. L. Kelly, F. E. Soroko and B. R. Cooper
J. Het. Chem., Vol. 33, No. 1, 33-39 (1996)

(2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5-dimethyl-2-morpholinol: A Novel Antidepressant Agent and Selective Inhibitor of Norepinephrine Uptake
Kelley, James L.; Musso, David L.; Boswell, G. Evan; Soroko, Francis E.; Cooper, Barrett R
Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, NC
Journal of Medicinal Chemistry, 39(2), 347-9 (1996)

Opioid Receptor Analgesics

"Opioid diarylmethylpiperazines and piperidines"
Inventors: K.-J. Chang, G. E. Boswell, D. G. Bubacz, M. A. Collins, A. O. Davis, R.W. McNutt, Jr.; R. Walton
US # 5,658,908

"Opioid diarylmethylpiperazines and piperidines"
Inventors: K.-J. Chang, G. E. Boswell, D. G. Bubacz, M. A. Collins, A. O. Davis, R.W. McNutt, Jr.; R. Walton
US # 5,854,249

"3-(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)- N-alkyl-N-arylbenzamides: Potent, Non-Peptidic Agonists of Both the mu and delta Opioid Receptors"
Bishop, Michael J.; Garrido, Dulce M.; Boswell, G. Evan; Collins, Mark A.; Harris, Philip A.; McNutt, Robert W.; O'Neill, Scott J.; Wei, Ke; Chang, Kwen-Jen GlaxoSmithKline Research and Development, Research Triangle Park, NC
Journal of Medicinal Chemistry, 46(4), 623-633 (2003)

"Synthesis, Stereochemistry, and Opioid Receptor Binding Acitvity of Heterocyclic Analogues of BW373U86"
*G. Evan Boswell, Robert W. McNutt, Dulce Bubacz, Ann O. Davis, Kwen-Jen Chang
J. Het. Chem., Vol. 32, No. 6, 1801-1818 (1995)

PPAR-gamma Agonists for Treatment of Diabetes

"Substituted 4-Hydroxy-phenylalconic acid Derivatives with Agonist Activity to PPAR-Gamma"
Inventors: T.M. Willson, R.A. Mook, I Kaldor, B. R. Henke, D.M. Deaton, J. L. Collins, J.E. Cobb, M. Brackeen, M. J. Sharp, J.M. O’Callaghan, G. A. Erickson, G. E. Boswell
PCT/EP97/00916

"N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety"
Collins J L; Blanchard S G; Boswell G E; Charifson P S; Cobb J E; Henke B R; Hull-Ryde E A; Kazmierski W M; Lake D H; Leesnitzer L M; Lehmann J; Lenhard J M; Orband-Miller L A; Gray-Nunez Y; Parks D J; Plunkett K D; Tong W Q
Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina, jlc@glaxowellcome.com
Journal of Medicinal Chemistry, 41(25), 5037-54 (Dec 3, 1998)

"N-(2-Benzoylphenyl)-L-tyrosine PPARg Agonists. 3. Structure-Activity Relationship and Optimization of the N-Aryl Substituent"
Cobb, Jeff E.; Blanchard, Steven G.; Boswell, Evan G.; Brown, Kathleen K.; Charifson, Paul S.; Cooper, Joel P.; Collins, Jon L.; Dezube, Milana; Henke, Brad R.; Hull-Ryde, Emily A.; Lake, Debra H.; Lenhard, James M.; Oliver, William, Jr.; Oplinger, Jeffery; Pentti, Mila; Parks, Derek J.; Plunket, Kelli D.; Tong, Wei-Qin
Glaxo Wellcome Research and Development, Research Triangle Park, NC
Journal of Medicinal Chemistry, 41(25), 5055-5069 (1998)

Steroids for Asthma

"Synthesis of steroid "antedrugs" for evaluation as safe treatments for asthma: Practical synthesis of the inhaled steroid GR250495X"
Sharp, Matthew J.; Andersen, Mark W.; Boswell, Evan G.; Glover, Bobby N.; Martin, Michael T.; Matsuoka, Richard T.; Zhou, Xiaoming.
Chemical Development Department, Glaxo Wellcome Inc., Research Triangle Park, NC
ACS Symposium Series, 817(From Bench to Pilot Plant), 31-44 (2002)

"Enantiomers of mercapto lactones and processes for their synthesis"
Andersen, Marc Werner; Boswell, Grady Evan; Sharp, Matthew Jude; Zhou, Xiaoming (Glaxo Group Limited, UK)
PCT Int. Appl. (2000)

"Synthesis of steroid 'antedrugs' for evaluation as safe treatments for asthma"
Sharp, Matthew J.; Andersen, Marc W.; Boswell, G. Evan; Glover, Bobby N.; Martin, Michael T.; Matsuoka, Richard T.; Zhou, Xiaoming.
Chemical Development Department, Glaxo Wellcome Inc, Research Triangle Park, NC
Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000, MEDI-335. Publisher: American Chemical Society, Washington, DC

Miscellaneous

"Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase"
Musso, David L.; Clarke, Morris J.; Kelley, James L.; Boswell, G. Evan; Chen, Grace. GlaxoSmithKline Res. and Dev., Research Triangle Park, NC
Organic & Biomolecular Chemistry, 1(3), 498-506 (2003)

"Synthesis and anticonvulsant activity of a series of benzamides"
Musso, D. L.; Boswell, G. E.; Mehta, N. B.; Soroko, F. E.; Burchall, C. J.
Div. Organic Chem., Div. Pharmacology, Research Triangle Park, NC
European Journal of Medicinal Chemistry, 31(4), 331-334 (1996)

"Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils"
Orr, G. Faye; Musso, David L.; Boswell, G. Evan; Kelley, James L.; Joyner, Suzanne S.; Davis, Stephen T.; Baccanari, David P.
Division of Organic Chemistry, Burroughs Wellcome Company, Research Triangle Park, NC
Journal of Medicinal Chemistry, 38(19), 3850-6 (1995)

"A Convenient Large-Scale Synthesis of 4-fluoro-1-naphthaldehyde and its Aromatic Nucleophilic Substitution Reactions"
*G. Evan Boswell and Joseph F. Licause
J. Org. Chem., 60, 6592-6594 (1995)


Contact Information


Academic Office

Graduate School of Biomedical Sciences and Professional Studies
245 N. 15th Street, MS 344
New College Bldg., Rm. 4104
Philadelphia, PA 19102
Phone: 215.762.4674