"Role of HBx in hepatitis B virus persistence and its therapeutic implications"
Slagle, B. L. and M. J. Bouchard
Curr Opin Virol 30: 32-38 (2018)

"A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways."
Lamontagne, R. J., et al.
Metabolism 83: 50-59 (2018)

"Hepatitis B virus X protein modulates cytosolic Ca(2+) signaling in primary human hepatocytes."
Casciano, J. C. and M. J. Bouchard
Virus Res 246: 23-27 (2018)

"Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes"
Casciano, J. C., Duchemin, N. J., Lamontagne, R. J., Steel, L. F., & Bouchard, M. J.
PloS One, 12(2), e0168328. doi:10.1371/journal.pone.0168328 (2017)

"Measuring Changes in Cytosolic Calcium Levels in HBV- and HBx-Expressing Cultured Primary Hepatocytes."
Casciano, J. C. and M. J. Bouchard
Methods Mol Biol 1540: 143-155 (2017)

"Hepatitis B virus molecular biology and pathogenesis"
R.J. Lamontagne, S. Bagga, M.J. Bouchard
Hepatoma Research, [S.l.], v.2, n.7, p.163-186 (July 2016)

"Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation"
Mehta, A., Comunale, M. A., Rawat, S., Casciano, J. C., Lamontagne, J., Herrera, H., Ramanathan, A., Betesh, L., Wang, M., Norton, P., Steel, L. F., Bouchard, M. J.
Scientific Reports, 6, 27965. doi:10.1038/srep27965 (2016)

"Transcriptome-Wide Analysis of Hepatitis B Virus-Mediated Changes to Normal Hepatocyte Gene Expression"
Lamontagne, J., Mell, J. C., & Bouchard, M. J.
PLoS Pathogens, 12(2), e1005438. doi:10.1371/journal.ppat.1005438 (2016)

"Hepatitis B Virus X and Regulation of Viral Gene Expression"
Slagle, B. L., & Bouchard, M. J.
Cold Spring Harbor Perspectives in Medicine, 6(3), a021402. doi:10.1101/cshperspect.a021402 (2016)

"Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication"
S. Bagga, S. Rawat, M. Ajenjo, M.J. Bouchard
Virology, v.498, n.0, pgs.9-22 (2016)

"Interstitial Fluid Flow Increases Hepatocellular Carcinoma Cell Invasion through CXCR4/CXCL12 and MEK/ERK Signaling"
Shah, A. D., Bouchard, M. J., & Shieh, A. C.
PloS One, 10(11), e0142337. doi:10.1371/journal.pone.0142337 (2015)

"Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases"
Lamontagne, J., Steel, L. F., & Bouchard, M. J.
World Journal of Gastroenterology, 21(24), 7375-99 (2015)

"Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms"
Kang, Y. B., et al.
Biotechnol Bioeng 112(12): 2571-2582 (2015)

"The Hepatitis B Virus HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival"
S. Rawat and M. Bouchard
J. Virol, 89(2):999-1012 (2015)

"Technical standards for hepatitis B virus X protein(HBx) research"
B. Slagle, O. Andrisani, M. Bouchard, C. Lee, J. Ou, A. Siddiqui
Hepatology, Epub (August 7, 2014)

"Cell cycle regulation during viral infection"
S. Bagga and M. Bouchard
Methods Mol Biol. 1170:165-227 (2014)

"Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding"
L. Rice, M. Donigan, M. Yang, W. Liu, D. Pandya, B.K. Joseph, V. Sodi, T.L. Gearhart, J. Yip, M. Bouchard, J.T. Nickels Jr.
J. Biol Chem, 289(24):17268-79 (2014)

"Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid"
Y.B. Kang, S. Rawat, J. Cirillo, M. Bouchard, H.M. Noh
Biofabrication, 5(4):045008. doi:10.1088/1758-5082/5/4/045008. Epub Nov. 26, 2013 (December 2013)

"Modulation of apoptotic signaling by the hepatitis B virus X protein"
S. Rawat, A. Clippinger, M. Bouchard
Viruses, 8: 2945-72 (2012)

"The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake"
B. Yang and M. Bouchard
J Virol., 86: 313-327 (2012)

"The C-terminal region of the hepatitis B virus X protein is essential for its stability and function"
R. Lizzano, B. Yang, A. Clippinger, M. Bouchard
Virus Res., 155: 231-239 (2011)

"The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes"
T. Gearhart and M. Bouchard
Virus Res., 155: 363-367 (2011)

"Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges"
M. Bouchard and S. Navas-Martin
Cancer Letters, 305: 123-43 (2011)

"Replication of the hepatitis B virus requires a calcium-dependent HBx-Induced G1 phase arrest of hepatocytes"
T. Gearhart and M. Bouchard
Virology, 407: 14-25 (2010)

"The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication"
T. Gearhart and M. Bouchard
Journal of Virology, 84: 2675-2686 (2010)

"In situ intracellular spectroscopy with surface enhanced raman spectroscopy (SERS)-enabled nanopipettes"
E.A. Vitol, Z. Orynbayeva, M. Bouchard, J. Azizkhan-Clifford, G. Friedman, Y. Gogotsi
ACS Nano, 3; 3529-3536 (2009)

"The hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kB and the mitochondrial permeability transition pore"
A. Clippinger, T. Gearhart, M. Bouchard
Journal of Virology, 83: 4718-4713 (2009)

"Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential"
A. Clippinger and M. Bouchard
Journal of Virology, 82: 6798-6811 (2008)

"Microfluidic platform for hepatitis B viral replication study"
T. Sodunke, M. Bouchard, H. Noh
Biomed Microdevices, 10: 393-402 (2008)

"Regulation of cellular signal transduction cascades by the hepatitis B virus X protein"
M. Bouchard and S. McClain
In: The pleiotropic functions of the viral protein HBx in Hepatitis B virus infection and the development of liver cancer, J. Kobarg (Ed). Research Signpost 37/661: 241-264 (2007)

"HBV replication is associated with an HBx-dependent mitochondrial-regulated increase in intracellular calcium levels"
S. McClain, A. Clippinger, R. Lizzano, M. Bouchard
Journal of Virology, 81: 12061-12065 (2007)

"Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication"
M. Bouchard, L-H. Wang, R. Schneider
Journal of Virology, 80: 4406-4414 (2006)

"The enigmatic X gene of hepatitis B virus"
Bouchard, M. J., & Schneider, R. J.
Journal of Virology, 78(23), 12725-34 (2004)

"Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication"
Bouchard, M. J., Puro, R. J., Wang, L., & Schneider, R. J.
Journal of Virology, 77(14), 7713-9 (2003)

"Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication"
Bouchard, M. J., et al.
Science 294(5550): 2376-2378 (2001)

 
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