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Leslie Ain McClure, PhD, MS

Leslie McClure

Professor, Chair
Epidemiology and Biostatistics
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BS of Mathematics, University of Kansas; MS of Preventive Medicine & Environmental Health, University of Iowa; PhD of Biostatistics, University of Michigan


Dr. McClure has diverse research interests, ranging from statistical methodology to environmental epidemiology. Methodologically, Dr. McClure is interested in the design and analysis of randomized clinical trials with multiple outcomes, and methodology for reestimating sample size in on-going randomized trials. She has served as the principle investigator for the Statistical Center for the Secondary Prevention of Small Subcortical Strokes (SPS3) study, and as the statistical investigator on several other smaller clinical trials. In addition, Dr. McClure is interested in racial and geographic disparities in diseases and the role that the environment plays in those disparities. She served as PI of a NASA grant in which her team investigated the role of satellite derived measures of fine particulate matter in the development of cognitive decline and stroke, and is currently co-PI of a grant concerned with the impact of trace element levels on stroke risk.

In addition, Dr. McClure loves to teach and to work with students, and has been recognized by the University of Alabama at Birmingham for her outstanding teaching and mentoring skills.


Research Interests

  • Cardiovascular Disease
  • Clinical Trials
  • Environmental Exposures
  • Statistical Modeling
  • Adaptive Designs in Clinical Trials
  • Statistical Methods for Environmental Epidemiology


Loop MS, McClure LA. Testing for clustering at many ranges inflates family-wise error rate (FWE). Int J Health Geogr. 2015 Jan 15;14:4. PubMed PMID: 25588612; PubMed Central PMCID: PMC4326498.

Loop MS, Kent ST, Al-Hamdan MZ, Crosson WL, Estes SM, Estes MG Jr, Quattrochi DA, Hemmings SN, Wadley VG, McClure LA. Correction: Fine particulate matter and incident cognitive impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. PLOS ONE. 2015;10(4):e0125137. PubMed PMID: 25886257; PubMed Central PMCID: PMC4401742.

Schwebel DC, McClure LA, Severson J. Teaching children to cross streets safely: a randomized, controlled trial. Health Psychol. 2014 Jul;33(7):628-38. PubMed PMID: 24447187; PubMed Central PMCID: PMC4101996.

McClure LA, Kleindorfer DO, Kissela BM, Cushman M, Soliman EZ, Howard G. Assessing the performance of the Framingham Stroke Risk Score in the reasons for geographic and racial differences in stroke cohort. Stroke. 2014 Jun;45(6):1716-20. PubMed PMID: 24736237; PubMed Central PMCID: PMC4102650.

Kent ST, Cushman M, Howard G, Judd SE, Crosson WL, Al-Hamdan MZ, McClure LA. Sunlight exposure and cardiovascular risk factors in the REGARDS study: a cross-sectional split-sample analysis. BMC Neurol. 2014 Jun 19;14:133. PubMed PMID: 24946776; PubMed Central PMCID: PMC4075775.

McClure LA, Coffey CS, Howard G. Monitoring futility in a two-by-two factorial design: the SPS3 experience. Clin Trials. 2013 Apr;10(2):250-6. PubMed PMID: 23378483; PubMed Central PMCID: PMC3731445.

Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012 Aug 30;367(9):817-25. PubMed PMID: 22931315; PubMed Central PMCID: PMC4067036.