Chemistry Seminar: Total Synthesis of (−)-Calyciphylline N
Thursday, April 6, 2017
4:30 PM-6:00 PM
Artem Shvartsbart,
Incyte Inc.
"Total Synthesis of (−)-Calyciphylline N"
The total synthesis of the architecturally complex Daphniphyllum alkaloid (−)-calyciphylline N will be presented. Highlights of the synthesis include a Et2AlCl-promoted, highly stereoselective, substrate-controlled intramolecular Diels–Alder reaction, a transannular enolate alkylation, an effective Stille carbonylation/Nazarov cyclization sequence, and a high-risk diastereoselective hydrogenation of a fully substituted conjugated diene ester.
Contact Information
Hai-Feng (Frank) JI, PhD
215.895.2562
hj56@drexel.edu
Location
Disque Hall 109, 32 South 32nd Street, Philadelphia, PA 19104
Audience
- Undergraduate Students
- Graduate Students
- Faculty
- Staff
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