The role of TNF in neuroinflammation following spinal cord injury. Two forms of TNF exist, a soluble form and a transmembrane form which bind preferentially TNFR1 and TNFR2, respectively. Soluble TNF is believed to be proinflammatory causing demyelination and neurodegeneration while transmembrane TNF signaling is neuroprotective and promote remyelination. We are using both in vitro and in vivo approaches to understand how TNFR2 signaling in glial cells promotes remyelination.
We are also interested in the peripheral consequences of spinal cord injury on the immune system and metabolism.