Jiu Jiang, PhD
Research Associate Professor
Department of Biology
- MS, MD, Bengbu Medical College, Bengbu, P.R. China
- PhD, Shanghai Second Medical University, Shanghai, P.R. China
- Post-Doc, University of Pennsylvania School of Medicine
Aging is associated with decreased expansion of T cells upon stimulation. By using influenza virus, LCMV and TCR transgenic mice, I am working on the mechanisms of impairment of specific CD8 T cell response in aged mice, which may have an important implication for understanding the alteration of immune response in aged individuals.
Aging and the mechanisms of impairment of specific CD8 T cell response in aged mice, the alteration of immune response in aged individuals.
- Jiang J, Fisher E, and Murasko DM. 2011. CD8 T Cell Responses to Influenza Virus Infection in Aged Mice. Ageing Res Rev 10(4):422-427.
- Williams-Bey Y, Jiang J, and Murasko DM. 2011. Expansion of Regulatory T cells in Aged Mice following Influenza Infection. Mech Ageing Dev 132 (4):163-170.
- He S, Kato K, Jiang J, Wahl DR, Mineishi S, Fisher EM, Murasko DM, Glick GD, Zhang Y. 2011. Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to o Generate Long-Lasting Memory Cells. PlosOne 6 (5): e20107.
- Fisher E, and Jiang J. 2012. Adjuvanted vaccines against influenza in the elderly. Frontiers Biol 221-226.
- Jiang ZL, Fisher E, Jiang J. 2012. Neonatal vaccination against respiratory syncytial virus infection. Frontiers Biol 227-232.
- Jiang J, Fisher E, and Murasko DM. 2013. Intrinsic Defects in CD8 T cells with Aging Contribute to Impaired Primary Antiviral Responses. Exp Gerontol 48 (6): 579-586.
- Jiang J, Fisher E, and Murasko DM. 2013. Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells. Immunity & Ageing 10:36 DOI: 10.1186/1742-4933-10-36.
- Jiang J, Fisher FM, Hensley SE, Lustigman S, Murasko DM, and Shen H. 2014. Antigen Sparing and Enhanced Protection Using A Novel rOv-ASP-1 Adjuvant in Aqueous Formulation with Influenza Vaccines. Vaccine 32(23):2696-2702.
- Concannon MA, Jiang J. 2014. The Effect of Adjuvant on Vaccine-Induced Antibody Response Against Influenza in Aged Mice. Frontiers Biol 9(2):89-94.
- Jiang J, Fisher FM, Concannon M, Shen H, and Murasko DM. 2015. Enhanced IgG Response to Influenza Vaccine in Aged Mice with A Novel Adjuvant, rOv-ASP-1. Vaccine (Submitted).